Effect of testosterone supplementation on sarcopenic components in middle-aged and elderly men: A systematic review and meta-analysis

Parahiba, Suena Medeiros; Ribeiro, Édina Caroline Ternus; Correa, Camila; Bieger, Patrícia; Perry, Ingrid Schweigert; Souza, Gabriela Corrêa

doi:10.1016/j.exger.2020.111106

Cited by 21 publications

(13 citation statements)

References 37 publications

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“…A recent meta-analysis demonstrated that TRT produced an increase in lean body mass of 2.54 kg (95% CI 1.27–3.80; p < 0.001) and an increase in handgrip strength of 1.58 kg (95% CI 0.17–3.0; p = 0.03) and concluded that TRT showed a beneficial effect on sarcopenic components, such as muscle mass and strength, as well as on physical performance in middle-aged and older adults [ 83 ]. Another recent systematic review also supports certain beneficial contributions of TRT to muscle condition and function [ 84 ].…”

Section: Efficacy Of Testosterone Replacement Therapy For Sarcopeniamentioning

confidence: 99%

Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review

Shigehara

Kato

Izumi

et al. 2022

JCM

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Age-related decline in testosterone is known to be associated with various clinical symptoms among older men and it is possible that the accompanying decline in muscle mass and strength might lead to a decline in motor and physical functions. Sarcopenia is an important pathophysiological factor associated with frailty in older adults and is diagnosed in older adults as a decrease in muscle strength, muscle mass, and walking speed, which can lead to a significant decline in the quality of life and shortened healthy life expectancy. Testosterone directly interacts with the androgen receptor expressed in myonuclei and satellite cells and is also indirectly associated with muscle metabolism through various cytokines and molecules. Currently, significant correlations between testosterone and frailty in men have been confirmed by numerous cross-sectional studies. Many randomized control studies have also supported the beneficial effect of testosterone replacement therapy (TRT) on muscle volume and strength among men with low to normal testosterone levels. In the world’s aging society, TRT can be a tool for preventing the onset of sarcopenia in older-adult men. This narrative review aims to show the relationship between the decline in testosterone with age, sarcopenia, and frailty, as well as the effects of testosterone replacement therapy on muscle mass and strength.

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Section: Efficacy Of Testosterone Replacement Therapy For Sarcopeniamentioning

confidence: 99%

Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review

Shigehara

Kato

Izumi

et al. 2022

JCM

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“…Sarcopenia and hypogonadism may be closely related, despite the prevalence of sarcopenic people with hypogonadism are still unknown ( Bhasin et al, 2018b ; Corona et al, 2020 ; Qaseem et al, 2020 ). Many sarcopenic men may also meet clinical criteria for hypogonadism, and TRT in this case can also improve physical function ( Parahiba et al, 2020 ; Varanoske et al, 2020 ).…”

Section: Anabolic-androgenic Steroids When Exercise Seems Ineffective...mentioning

confidence: 99%

“…In addition, the authors suggest that TRT may be recommended in men with low serum levels of total testosterone (<200–300 ng/dl) to manage the sarcopenia syndrome ( De Spiegeleer et al, 2018 ). In a recent meta-analysis with 773 middle-aged and elderly men, TRT was associated with an increase in muscle mass, strength, and physical performance ( Parahiba et al, 2020 ). Although this study was not conducted exclusively with sarcopenic individuals, the results demonstrated a significant effect of TRT in improving some sarcopenic features (muscle mass and physical function).…”

Section: Anabolic-androgenic Steroids When Exercise Seems Ineffective...mentioning

confidence: 99%

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Anabolic-Androgenic Steroids and Exercise Training: Breaking the Myths and Dealing With Better Outcome in Sarcopenia

2022

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Sarcopenia is an emerging clinical condition determined by the reduction in physical function and muscle mass, being a health concern since it impairs quality of life and survival. Exercise training is a well-known approach to improve physical capacities and body composition, hence managing sarcopenia progression and worsening. However, it may be an ineffective treatment for many elderly with exercise-intolerant conditions. Thus, the use of anabolic-androgenic steroids (AAS) may be a plausible strategy, since these drugs can increase physical function and muscle mass. The decision to initiate AAS treatment should be guided by an evidence-based patient-centric perspective, once the balance between risks and benefits may change depending on the clinical condition coexisting with sarcopenia. This mini-review points out a critical appraisal of evidence and limitation of exercise training and AAS to treat sarcopenia.

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“…In adult men, the age-related decline in serum T concentrations has been implicated in reduced muscle mass and muscle strength [ 17 ]. T has also been used as a clinical supplement for older men to promote muscle mass gain [ 18 ]. Moreover, several studies in adult men have reported that the positive relationship between serum T and muscle strength could be nonlinear.…”

Section: Introductionmentioning

confidence: 99%

Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty

Wen

Deng

et al. 2021

PLoS ONE

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This study analysed the associations of sex steroids with fat-free mass (FFM) and handgrip strength in 641 Chinese boys. Serum total testosterone (TT) and oestradiol were measured by chemiluminescence immunoassay. Free testosterone (FT) and oestradiol were calculated. FFM and handgrip strength were measured by bioelectrical impedance analysis and a hand dynamometer, respectively. Generalised additive models and multiple linear regression were used to explore the relationships. A subgroup analysis was conducted in early-mid pubertal and late-post pubertal groups. Age, height, weight, physical activity, intake of dietary protein and/or stage of puberty were adjusted. TT and FT were positively related to FFM and handgrip strength, with a curvilinear relationship being detected for handgrip strength (p<0.050). This curvilinear relationship was only observed in the late-post pubertal group, suggesting a potential threshold effect (FT>11.99ng/dL, β = 1.275, p = 0.039). In the early-mid pubertal group, TT and/or FT were linearly or near-linearly related to FFM or handgrip strength (β = 0.003–0.271, p<0.050). The association between FT and FFM was stronger than that in the late-post pubertal group. This study found that serum T had different associations with muscle parameters in Chinese early-mid pubertal and late-post pubertal boys. In the late-post pubertal boys, serum T was curvilinearly related to muscle strength with a threshold effect and its link with muscle mass was weaker.

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Effect of testosterone supplementation on sarcopenic components in middle-aged and elderly men: A systematic review and meta-analysis

Cited by 21 publications

References 37 publications

Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review

Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review

Anabolic-Androgenic Steroids and Exercise Training: Breaking the Myths and Dealing With Better Outcome in Sarcopenia

Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty

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