2013
DOI: 10.6116/kjh.2013.28.1.83
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Effect of Tetramethylpyrazine on Pro-Inflammatory Cytokine Expressions in Mouse Brain Tissue following Intracerebroventricular Lipopolysaccharide Treatment

Abstract: Objectives : Tetramethylpyrazine (TMP) is an active ingredient in Ligusticum wallichii and has a wide range of neuroprotection effects. This study investigated anti-neuroinflammatory effect of TMP on brain regions in intracerebroventricular (i.c.v.) lipopolysaccharide (LPS)-treated C57BL/6 mice. Methods : TMP was administered intraperitoneally at doses of 10, 20, and 30 mg/kg at 1 h prior to LPS (3 mg/kg) i.c.v. injection. mRNA level of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), int… Show more

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“…The pro-inflammatory cytokines such as IL-6, TNF-α, IL-1β are mediators in inflammatory immune responses, and prolonged responses can lead to skin inflammation and cancer (Weisz et al, 1996;Choi et al, 2013). To test for any anti-inflammatory effect of SFEE using crude enzyme from S. oneidensis PKA 1008, the inhibition effect of IL-6, TNF-α, and IL-1β production in LPS-induced RAW 264.7 macrophages was investigated.…”
Section: Inhibitory Effect On Production Of Lps-induced Il-6 Tnf-α An...mentioning
confidence: 99%
“…The pro-inflammatory cytokines such as IL-6, TNF-α, IL-1β are mediators in inflammatory immune responses, and prolonged responses can lead to skin inflammation and cancer (Weisz et al, 1996;Choi et al, 2013). To test for any anti-inflammatory effect of SFEE using crude enzyme from S. oneidensis PKA 1008, the inhibition effect of IL-6, TNF-α, and IL-1β production in LPS-induced RAW 264.7 macrophages was investigated.…”
Section: Inhibitory Effect On Production Of Lps-induced Il-6 Tnf-α An...mentioning
confidence: 99%