Effect of the &amp;lt;i&amp;gt;IGF-I&amp;lt;/i&amp;gt; gene polymorphism on growth, body size, carcass and meat quality traits in Coloured Polish Merino sheep

Grochowska, Ewa; Borys, B.; Janiszewski, P.; Knapik, Jan; Mroczkowski, S.

doi:10.5194/aab-60-161-2017

Cited by 22 publications

(18 citation statements)

References 38 publications

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“…The IGF1 SNP genotyped in Sarda sheep (rs159876390) was associated with protein and casein contents (P < 0.05). This result was not described in previous reports, where attention was more focused on growth-related traits (Grochowska et al, 2017) and reproduction traits (He et al, 2012). Crisà et al (2010) Figure 2.…”

Section: Discussioncontrasting

confidence: 93%

Association between the GHR, GHRHR, and IGF1 gene polymorphisms and milk yield and quality traits in Sarda sheep

Dettori

Pazzola

Paschino

et al. 2018

Journal of Dairy Science

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The growth hormone receptor (GHR), the growth hormone releasing hormone receptor (GHRHR), and the insulin-like growth factor 1 (IGF1) genes are known to modulate growth, reproduction, and lactation traits in livestock. The aim of the current work was to investigate if the variation of the sheep GHR, GHRHR, and IGF1 genes is associated with milk yield and quality traits. Three hundred eighty dairy Sarda sheep were genotyped for 36 single nucleotide polymorphisms (SNP) mapping to these 3 loci, and records for milk yield and daily fat and protein yield, as well as for fat, protein, casein, lactose, and milk urea contents, pH, somatic cell score, logarithmic bacterial count, and milk energy were obtained. The linkage disequilibrium analysis was performed only for GHR, as both GHRHR and IGF1 had only 1 polymorphic SNP. Haplotype analysis revealed the existence of 7 haplotype blocks in GHR. Two haplotype blocks, including part of the intron 1 and the upstream region, were clearly separated from the remaining 5 blocks by SNP rs412986330, which may be a recombination hotspot. The latter 5 blocks were contiguous, spanning from intron 2 to exon 10. Statistical analysis revealed that the GHR polymorphism is significantly associated with milk traits for daily fat and protein yield and fat, milk urea, and lactose content. Moreover, variation in IGF1 was associated with milk protein and casein content. Data generated in this research provide new insights into the allelic effects of the ovine GHRHR, GHR, and IGF1 genes on milk production and quality traits, information that may be useful in gene-assisted selection programs.

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Section: Discussioncontrasting

confidence: 93%

Association between the GHR, GHRHR, and IGF1 gene polymorphisms and milk yield and quality traits in Sarda sheep

Dettori

Pazzola

Paschino

et al. 2018

Journal of Dairy Science

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“…In total, 106 ram lambs at mean age 105 days (SD 4.2, range 92-119 days) were chosen for slaughter during the three years of the study. Slaughtering, carcass cutting, and leg dissection were done in the abattoir of the NRIAP Experimental Station Kołuda Wielka as described previously by Grochowska et al [23,24] according to the methodologies of Nawara et al [25] and Krupiński et al [26]. In brief, the slaughtering of ram lambs took place in batches, three or four times a year from March to April.…”

Section: Carcass Traitsmentioning

confidence: 99%

Effects of Intronic SNPs in the Myostatin Gene on Growth and Carcass Traits in Colored Polish Merino Sheep

Grochowska

Borys

Mroczkowski

2019

Genes

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Myostatin acts as a negative regulator of muscle growth; therefore, its role is important with regard to animal growth and meat production. This study was undertaken with the objective to detect polymorphisms in the first intron and c.*1232 position of the MSTN gene and to analyze effects of the detected alleles/genotypes on growth and carcass traits in Colored Polish Merino sheep. In total, 23 traits were analyzed, i.e., seven describing lamb growth and 16 carcass traits. Single nucleotide polymorphisms (SNPs) in the first intron and the c.*1232 position were identified using polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and PCR-restriction fragment length polymorphism (PCR-RFLP) methods, respectively. The MIXED procedure of the SAS software package was used to analyze allelic and genotypic effects of the MSTN gene on growth and carcass traits. Polymorphisms were only detected in the first intron of the MSTN gene. All investigated sheep were monomorphic G in the c.*1232 position. The MSTN genotype was found to have significant effect on body weight at 2nd day of life (BW2) and loin and fore shank weights. Significant allelic effects were detected with respect to BW2, scrag, leg, fore, and hind shank weights. These results suggest that polymorphisms in the first intron of the MSTN gene are relevant with respect to several carcass traits and BW2 in Colored Polish Merino sheep.

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“…The result of this study is different than results reported by Su et al (2014) who mentioned that IGF-I expression in Hu sheep increased from 2 days of birth and then continuously decreased until 3 months of age; thereafter, IGF-I expression gradually increased and reached the peak at 6 months of age, the expression of IGF-I in sheep that were 6 months of age was significant (P<0.01) and greater than at 1, 2, 3, and 4 months of age. The IGF1 gene plays an important purpose in the growth of multiple tissues, including mammalian muscle, somatic growth, and tissue repair (Nazari et al, 2016, Grochowska et al, 2017Rotwein, 2017). IGF-1 gene is considered to be a candidate gene for predicting growth and meat quality traits in sheep genetic improvement schemes.…”

Section: Gene Expression Analysismentioning

confidence: 99%

“…Even though the IGF-I gene plays a role in the growth of an organism, it could also be directly or indirectly associated with other traits, i.e. carcass and meat quality traits (Grochowska et al, 2017).…”

Section: Gene Expression Analysismentioning

confidence: 99%

“…The growth rate of lambs is an important production trait and it reflects the economic viability of animals, which has a great role in a sheep production process. It is primarily influenced by a complex system such as genetics, immune responses, physiological status, and endocrine factors, in addition to other non-genetic factors (Grochowska et al, 2017, Singh et al, 2018Veena et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Growth Performance, Blood Metabolites and Gene Expression Analysis in Egyptian Sheep Breeds, in Relation to Age

Ashour¹,

Gad²,

Fayed³

et al. 2020

jwpr

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The growth performance of lambs attributes the economic viability of animals. Faster growth allows lambs to reach maturity in early age. Therefore, the aim of this study was to compare growth performance, blood metabolites and expression of IGF-1, GH, and Leptin genes in three different Egyptian sheep breeds across age. Thirty Egyptian sheep males from three breeds (Ossimi, Rahmani and Barki) were divided into three ages categorize (7-9, 10-12, and 13-16 months). The results showed that there was a significant increase in sheep's live body weights toward advanced ages till the second age category for all breeds, the highest values of linear body measurements were observed in Ossimi breed. There was a non-significant inverse effect of advanced age on blood glucose and total lipids levels in all sheep breeds. There wasn't any significant effect of interaction between age and breed on plasma total protein concentrations. According to age categories, Barki breed showed a significant up-regulation of GH compared to the Ossimi breed in 7-9 months age category. However, Barki breed showed a significant downregulation of IGF-1compared to the Ossimi breed in 7-9 months. Meanwhile, Leptin expression showed significant differences in Ossimi breed between 10-12 months age category and two other age categories. We concluded that measuring of physical body measurements, blood metabolites and GH, IGF-1 and Leptin genes in early ages is a good and accurate indicator for growth performance in Egyptian sheep breeds.

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Effect of the <i>IGF-I</i> gene polymorphism on growth, body size, carcass and meat quality traits in Coloured Polish Merino sheep

Cited by 22 publications

References 38 publications

Association between the GHR, GHRHR, and IGF1 gene polymorphisms and milk yield and quality traits in Sarda sheep

Association between the GHR, GHRHR, and IGF1 gene polymorphisms and milk yield and quality traits in Sarda sheep

Effects of Intronic SNPs in the Myostatin Gene on Growth and Carcass Traits in Colored Polish Merino Sheep

Evaluation of Growth Performance, Blood Metabolites and Gene Expression Analysis in Egyptian Sheep Breeds, in Relation to Age

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