Effect of the Anesthetic and the Rate of Injection of Digitalis upon Its Lethal Dose in Cats*†

Effect of the Rate of Injection of Digitalis Upon its Lethal Dose in Guinea Pigs††This project was aided by a grant to the Department of Physiology and Pharmacology, College of Pharmacy, University of Nebraska, from Ciba Pharmaceutical Products, Inc.

“…1) was found to best fit the plotted points (log concentrations against geometric log doses) as contrasted to a straight line with a positive slope obtained by Holck, et al (5), in cats with the identical first five concentrations also using urethane anesthesia. 1) was found to best fit the plotted points (log concentrations against geometric log doses) as contrasted to a straight line with a positive slope obtained by Holck, et al (5), in cats with the identical first five concentrations also using urethane anesthesia.…”

“…The purpose of this study was to ascertain the effects of varying the concentration of the digitalis tincture and to compare the results with those of other investigators and also with those obtained in the cat studies of Holck, Kimura, and B artels (5). …”