Effect of the beta-3 adrenergic receptor Trp64Arg and uncoupling protein 1–3826 A > G genotypes on lipid and apolipoprotein levels in overweight/obese and non-obese Chinese subjects

Abstract

BackgroundThe beta-3 adrenergic receptor (β3-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826 A > G polymorphisms have been reported to be associated with obesity and/or lipid metabolism in some populations. This study examined the possible association of the β3-AR and UCP1 polymorphisms with overweight/obesity or lipid variation in a Southwest Chinese population.MethodsA total of 418 Han Chinese (249 overweight/obese and 169 healthy control subjects) in the Chengdu area were studied using PCR-RFLP analysis. Total serum cholesterol (TC) and triglycerides (TGs) were measured using an enzymatic method. High density lipoprotein cholesterol (HDL-C) was determined after sodium phosphotungstate/magnesium chloride precipitation of low-density lipoproteins by polyvinyl sulfate. Serum apolipoproteins were quantified by radial immunodiffusion.ResultsThe genotype and allele frequencies of the β3-AR Trp64Arg and UCP1 -3826 A > G polymorphisms in overweight/obese subjects exhibited no significant differences compared to the controls. However, subjects carrying the β3-AR TrpTrp genotype and UCP1 AG genotype had higher TG levels than those carrying the Arg allele and AA genotype, respectively (P < 0.05), while controls carrying the β3-AR Arg allele had significantly higher TC and apo AII concentrations than those carrying the TrpTrp genotype (P < 0.05). Additionally, subjects carrying the UCP1 AG genotype exhibited elevated apo C-II and apo C-III levels compared to those carrying the AA genotype (P < 0.05). We were unable to find an association of the UCP1 and β3-AR polymorphisms with low HDL-cholesterolemia in the overweight/obese subjects.ConclusionsThe present study provides evidence that the β3-AR Trp64Arg and UCP1 -3826 A > G polymorphisms are associated with TG levels in overweight/obese Chinese subjects and that the two polymorphisms are also associated with certain lipid and apolipoprotein variations, depending on BMI. However, these polymorphisms are not associated with overweight/obesity or low HDL-cholesterolemia in a Chinese population from the Chengdu area.

Blood lipids in patients with high and low physical activity depending on polymorphism of beta-2 and 3-adrenergic receptor genes

“…Williams and Thompson showed that walking and running decrease the risk of development of hypercholesterolaemia in an equally effective manner [7]. The results by Marigliano et al are in concordance with the data of the above discussed studies and demonstrate considerable positive effect of walking on lipid metabolism parameters [8]. At the same time, meta-analysis presented in 2018 by Oja et al failed to demonstrate the direct effect of walking on cholesterol, while its essential effect on body mass index (BMI) and blood pressure parameters was proven [9].…”

Association of DIO2 Thr92Ala Polymorphism With Pediatric Obesity In Japanese Children: A Case Control Study

“…Recently, BAT has been identi ed as a novel target of obesity, as it increases energy expenditure by non-shivering thermogenesis. BAT-related gene polymorphisms are associated with obesity (8)(9)(10)(11). However, these relationships have not yet been fully elucidated, especially in pediatric obesity.…”

“…These genes are key molecules in BAT thermogenesis. In fact, some studies have demonstrated that these genes are associated with the pathogenesis of adulthood obesity (8)(9)(10)(11). However, few studies have reported the association between these genes and pediatric obesity.…”

New Therapeutic Agents in Obesity-Related Cardiovascular Disorders: Molecular and Cellular Insights

“…Those pathological stimuli trigger further a cascade of pathological events in cells although some studies proposed those stimuli as the group of cardioprotective signaling molecules, mainly in pre-and post-conditioning processes. Interestingly, some early and recent studies, particularly obesity studies in animals, highlighted an important anti-obesity and anti-diabetic effect of some selective beta-3 adrenergic receptor (β 3 -AR) agonists [94][95][96][97][98]. Indeed, some studies summarized the beneficial effects of some β 3 -AR agonists for the treatment of diabetes and obesity as increase lipolysis, fat oxidation, energy expenditure, and insulin action.…”