Effect of the Conformation of Poly(L-lactide-&lt;i&gt;co&lt;/i&gt;-glycolide) Molecules in Organic Solvents on Nanoparticle Size

BACKGROUND: Inhalable nanocomposite particles using O/W emulsions were studied. The effect of the composition of the dispersed phase on the nanoparticles in the nanocomposite particles was reported, however, the effect on the inhalation characteristics of nanocomposite particles has not been investigated. OBJECTIVE: The aim of this study was to study the effects of lower alcohols in the dispersed phase of O/W emulsions on inhalable nanocomposite particles. METHODS: Nanocomposite particles were prepared using a spray dryer from O/W emulsion. A mixed solution of dichloromethane and lower alcohols in which rifampicin (RFP) and poly(L-lactide-co-glycolide) were dissolved was used as a dispersed phase, and an aqueous solution in which arginine and leucine were dissolved was used as a continuous phase. RESULTS: We succeeded in preparing non-spherical nanocomposite particles with an average diameter of 9.01–10.91 μm. The results of the fine particle fraction (FPF) measurement showed that the higher the hydrophobicity of the lower alcohol mixed in the dispersed phase, the higher the FPF value. The FPF value of the nanocomposite particles was significantly increased by using ethanol and 1-propanol. CONCLUSIONS: The results were revealed that mixing 1-propanol with the dispersed phase increased the amount of RFP delivered to the lungs.

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Effects of lower alcohols on nanocomposite particles for inhalation prepared using O/W emulsion

Takeuchi

Kimura

Nakajima

et al. 2022

BME

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Effects of Polyvinyl Alcohol on Drug Release from Nanocomposite Particles Using Poly (L-lactide-<i>co</i>-glycolide)

2021

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namic diameter of 1-3 μm are deposited minimally in the mouth and throat and maximally in the lung parenchymal regions, such as the alveolar or deep-lung region 5 . Thus, inhalable nanocomposite particles are a promising inhalation system. Furthermore, nanoparticles can overcome mucus clearance 6 . In addition to macrophages, they are also taken up by other cells such as cancer cells and epithelial cells 7 10 . These properties of nanoparticles are useful for drug delivery; however, the size of nanoparticles is not suitable for inhalation. Nanocomposite particles with an aerodynamic diameter suitable for inhalation are used to solve this problem. Since these particles use diluents soluble in the alveoli lining fluid, they are decomposed into nanoparticles after reaching the alveoli 10 . Recently, it was reported that nanocomposite particles for inhalation improved the concentration of drug in the lungs. These

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Effect of the Conformation of Poly(L-lactide-<i>co</i>-glycolide) Molecules in Organic Solvents on Nanoparticle Size

Cited by 2 publications

References 30 publications

Effects of lower alcohols on nanocomposite particles for inhalation prepared using O/W emulsion

Effects of lower alcohols on nanocomposite particles for inhalation prepared using O/W emulsion

Effects of Polyvinyl Alcohol on Drug Release from Nanocomposite Particles Using Poly (L-lactide-<i>co</i>-glycolide)

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