Effect of the coordinated reset stimulations on controlling absence seizure

Wang, Zhihui; Wang, Qingyun

doi:10.1007/s11431-016-9043-3

Cited by 7 publications

(5 citation statements)

References 40 publications

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“…Using the model proposed by Wang and Wang (2017) as the original model, this study proposed and constructed a BCCT network. Based on the original model of a single ventricle, a second ventricle was introduced to connect the original single ventricle to construct the BCCT network.…”

Section: Model and Approach To Stimulationmentioning

confidence: 99%

“…Simultaneously, bilateral symmetrical spike‐and‐wave discharges (SWDs) of 3 Hz can be observed on an electroencephalogram (EEG) of both hemispheres of the patient's brain (Kannathal et al, 2005; Serna et al, 2020). The cortico‐thalamic (CT) network (Wang & Wang, 2017) plays an important role in the anatomical structure of the brain. Its discharge activity affects the neurophysiological state of the brain, including sleep and the occurrence of epilepsy (Gasparini et al, 2019; Sitnikova & van Luijtelaar, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Combined effect of stimulation and electromagnetic induction on absence seizure inhibition in coupled thalamocortical circuits

Zhang

Pan

Chai

2023

Eur J of Neuroscience

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Deep brain stimulation (DBS) and electromagnetic induction are new techniques that are increasingly used in modern epilepsy treatments; however, the mechanism of action remains unclear. In this study, we constructed a bidirectional-coupled cortico-thalamic model, based on which we proposed three regulation schemes: isolated regulation of DBS, isolated regulation of electromagnetic induction and combined regulation of the previous two. In particular, we introduced DBS with a lower amplitude and considered the influence of electromagnetic induction caused by the transmembrane current on the membrane potential. The most striking finding of this study is that the three therapeutic schemes could effectively control abnormal discharge, and combined regulation could reduce the occurrence of epileptic seizures more effectively. The present study bridges the gap between the bidirectional coupling model and combined control. In this way, the damage induced by electrical stimulation of the patient's brain tissue could be reduced, and the abnormal physiological discharge pattern of the cerebral cortex was simultaneously regulated by different techniques. This work opens new avenues for improving brain dysfunction in patients with epilepsy, expands ideas for promoting the development of neuroscience and is meaningful for improving the health of modern society and developing the field of science. K E Y W O R D S bidirectional-coupled cortico-thalamic model, electromagnetic induction deep brain stimulation, epilepsy 1 | INTRODUCTIONEpilepsy, caused by abnormal synchronous firing of neurons in the brain, is a common neurological disease worldwide (Takami & Nakagawa, 2021). Epileptic seizures can be divided into partial and comprehensive seizures (Benbadis, 2005;Krumholz et al., 2015), such as generalised tonic-clonic seizures, tonic seizures and

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Section: Model and Approach To Stimulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combined effect of stimulation and electromagnetic induction on absence seizure inhibition in coupled thalamocortical circuits

Zhang

Pan

Chai

2023

Eur J of Neuroscience

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“…Based on the mean-field model, DBS is simulated as the applied electric field generated by the stimulation electrode (fig. 1(a)) [19][20][21][22][23]. The specific modeling method is shown in the following two equations:…”

mentioning

confidence: 99%

“…φ DBS is the input pulse that stimulates an electric field generated by an electrode. This modeling method is used to explore the effect of DBS on absence epilepsy, focusing on the modulation effect of external stimulation on spike and slow-wave discharges [21][22][23]. Wang et al investigated the impact of coordinated reset stimulation (CRS), which involves intermittent pulsed currents applied to the cortex, specific relay nucleus (SRN), and thalamic reticular nucleus (TRN), on the control of absence seizures using a cortical-thalamic mean-field model [21].…”

mentioning

confidence: 99%

“…This modeling method is used to explore the effect of DBS on absence epilepsy, focusing on the modulation effect of external stimulation on spike and slow-wave discharges [21][22][23]. Wang et al investigated the impact of coordinated reset stimulation (CRS), which involves intermittent pulsed currents applied to the cortex, specific relay nucleus (SRN), and thalamic reticular nucleus (TRN), on the control of absence seizures using a cortical-thalamic mean-field model [21]. Two-dimensional bifurcation maps revealed that CRS was effective in controlling absence seizures within the appropriate range of stimulation parameters.…”

mentioning

confidence: 99%

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Dynamic modeling of neuromodulation techniques: Towards elaboration and individual specificity

Yu,

Han,

Wang

2024

EPL

Self Cite

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Neurological disorders place a significant burden on patients, their families, and society, posing immense scientific challenges in terms of treatment and mechanistic research. Neuromodulation involves the application of invasive or non-invasive technologies to externally manipulate the nervous system of the brain, aiming to provide excitatory or inhibitory modulation that can improve abnormal neural activity. In the previous studies, neurodynamic analysis methods have not only provided novel tools for the study of neuromodulation techniques, but also provided new modulation strategies for the diagnosis and treatment of neurological diseases. In this paper, we present a brief overview of the current state of dynamic modeling and analysis for various neuromodulation techniques, including electrical, optical, magnetical, and ultrasonic approaches, and discuss the future prospects of modeling and analysis developments in neuromodulation.

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Stimulation strategies for absence seizures: targeted therapy of the focus in coupled thalamocortical model

Wang

2019

Nonlinear Dyn

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Effect of the coordinated reset stimulations on controlling absence seizure

Cited by 7 publications

References 40 publications

Combined effect of stimulation and electromagnetic induction on absence seizure inhibition in coupled thalamocortical circuits

Combined effect of stimulation and electromagnetic induction on absence seizure inhibition in coupled thalamocortical circuits

Dynamic modeling of neuromodulation techniques: Towards elaboration and individual specificity

Stimulation strategies for absence seizures: targeted therapy of the focus in coupled thalamocortical model

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