Effect of the Degree of Acetylation of Chitin Nonwoven Fabrics for Promoting Wound Healing

Abstract

Chitin and chitosan have been extensively used as wound dressings because of their special functions to promote wound healing. However, there was little focus on the effects of the degree of acetylation (DA) on wound healing. In this work, the regenerated chitin nonwoven fabrics with DA values of 90, 71, 60, and 42% were prepared, and the morphology and physical performances of the fabrics were characterized. Moreover, the effects of DA of the chitin nonwoven fabrics on wound recovery were studied with a full-thickness skin defect model in rats. In vitro experiments indicated that the chitin nonwoven fabrics exhibited good biocompatibility and blood compatibility and a low blood-clotting index (BCI). In vivo experiments revealed that the chitin nonwoven fabrics could accelerate wound healing more effectively than gauze by promoting re-epithelialization and collagen deposition as well as by stimulating neovascularization. The results of the wound healing process showed that DA of the chitin nonwoven fabrics had a profound effect on promoting wound healing. Notably, the regenerated chitin nonwoven fabrics with 71% DA significantly improved the wound healing compared to the commercial wound dressing Algoplaque film. Therefore, the regenerated chitin nonwoven fabrics are promising candidates for wound healing.

Facile fabrication of chitin/ZnO composite hydrogels for infected wound healing

“…3e). Noticeably, chitin has been widely employed as dressings to promote wound healing, 47,48 so CG hydrogels could promote the wound closure to a certain extent, and the mupirocin group demonstrated a speeding tendency to wound healing compared to the CG hydrogel-treated group, which may be attributed to the controllable infection. Quantitative wound closure rate analysis is shown in Fig.…”

Recent developments of polysaccharide‐based double‐network hydrogels

“…Nano-chitin could be obtained by the "top-down" method (e.g., acid hydrolysis, 58 mechanical treatment, 59 TEMPO-mediated oxidation, 60 and tandem molecular intercalation, etc.) 61 and the "bottom-up" method (e.g., wet-spinning method, 62 self-assembly method, 63 and dissolution-regeneration method, etc.). 64 Shi et al 65 reported a "building block reorganization" strategy to prepare chitin-based DN film.…”

Facile production of chitin from shrimp shells using a deep eutectic solvent and acetic acid

“…5–7 Owing to these desirable characteristics, chitin has recently attracted substantial research attention and has been widely used in numerous application areas, including food, medicine, agriculture, and other related fields. 8–10 In particular, chitin has been processed into a number of organo-nitrogen containing chemicals. 11,12…”

“…[5][6][7] Owing to these desirable characteristics, chitin has recently attracted substantial research attention and has been widely used in numerous application areas, including food, medicine, agriculture, and other related elds. [8][9][10] In particular, chitin has been processed into a number of organonitrogen containing chemicals. 11,12 Every year, approximately 6-8 million tons of crustacean shell waste are discarded by the seafood industry, thus simultaneously wasting resources and polluting the environment.…”