Facile fabrication of chitin/ZnO composite hydrogels for infected wound healing

Zhang, Hongli; Zhang, Xu; Cao, Qi; Wu, Shyi-Kuen; Wu, Xiaoqiang; Peng, Na; Zeng, Danlin; Liao, Jinfeng; Xu, Huan

doi:10.1039/d2bm00340f

Cited by 17 publications

(4 citation statements)

References 49 publications

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“…3c and 3d). Both of the growth curve of S. aureus and E. coli showed a trend of "S" type within 24 h, and the CZG-2 hydrogels can completely inhibit both S. aureus and E. coli growth when the initial bacterial concentration was 10 5 and 10 6 CFU/mL, which was similar to that in the reported works (Ma et al, 2020;Dutta et al, 2012;Zhang et al, 2022;Reyes et al, 2017). And the inhibitory effect of CZG-2 hydrogels was decreased to some extent after 14 h, when the initial higher bacterial concentration of 10 7 CFU/mL, which was seldom applied.…”

Section: Antibacterial Activity and Investigation Of Bio Lm Inhibitio...supporting

confidence: 87%

ZnO-incorporated chitin hydrogels for infected wound therapy

Zhang,

Xu,

Wang

et al. 2024

Cellulose

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Chronic wounds caused by pathogenic bacterial infections have been a worldwide medical threat and challenge, ZnO is a promising antibacterial agent to promote infected wound healing. However, ZnO particles need to be with a wound dressing material to improve low-dose antibacterial e cacy while reducing cytotoxicity. The natural polysaccharide, chitin-based hydrogels can be applied as a preferential supporting matrix for the deposition of ZnO. In this study, we developed chitin/ZnO composite hydrogels (CZG hydrogels), which were applied for the bio lm-infected full-thickness wound treatment. The threedimensional hydrophilic network structure of chitin hydrogels provided a large number of absorption sites for Zn 2+ ions, and CZG hydrogels were prepared by in situ synthesis of ZnO. CZG hydrogels had potent broad-spectrum and long-lasting antibacterial activity, good bacteriostatic ability against high concentration of bacterial uids. The in vivo studies showed that CZG hydrogels have a signi cant effect of accelerating bio lm-infected wound healing. Collectively, this work con rmed that chitin hydrogels could be applied as a preferential natural supporting matrix for the deposition of inorganic metal and metal oxide nanoparticles, and provided alternative antibacterial dressing for treating microbial infections and promoting wound healing.hydrogels have multiple advantages such as biocompatibility, biodegradability, and three-dimensional hydrophilic polymer network structure similar to the macromolecular biological tissue, which are extensively used in biomedical application (Huang et al., 2021;Kang et al., 2022;Anitha et al., 2014). To improve its properties and broaden its applications, chitin hydrogel has been modi ed, such as with polyphenol or hydroxyapatite (Cao et al., 2023;Xing et al., 2021;Lin et al., 2021a). In our previous work, Mn 3 O 4 nanoparticles were formed in the network of chitin hydrogels via in situ mineralization process and encapsulated to fabricate novel chitin/Mn 3 O 4 composite hydrogels, with NIR-assisted outstanding photothermal antibacterial and antibio lm activities (Zhang et al., 2023). Thereby, chitin hydrogels can be applied as a preferential natural supporting matrix for the deposition of ZnO.Hence, in this work, we attempted to fabricate chitin/ZnO composite hydrogels by in situ conversion of Zn 2+ to ZnO throughout chitin hydrogel networks. It is anticipated that chitin/ZnO composite hydrogels combine their unique properties. Therefore, the broad-spectrum antibacterial activity and biocompatibility of chitin/ZnO composite hydrogels were systematically investigated. Furthermore, the wound healing performance of the chitin/ZnO composite hydrogels was evaluated in a mouse full-thickness S. aureus bio lm-infected wound model. Materials and methods MaterialsThe raw chitin from shrimp shell was purchased from Zhejiang Golden-Shell Biochemical Co. Ltd., China, and puri ed according to the reported procedure (Ding et al., 2012). NH 3 •H 2 O, Zn(NO 3 ) 2 •6H 2 O, and other reagents were of...

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Section: Antibacterial Activity and Investigation Of Bio Lm Inhibitio...supporting

confidence: 87%

ZnO-incorporated chitin hydrogels for infected wound therapy

Zhang,

Xu,

Wang

et al. 2024

Cellulose

Self Cite

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“…Moreover, the hydrogel possesses a pH-responsive swelling-shrinking property, which allows for controlled and sustained release of Ag + and Zn 2+ , resulting in synergistic antibacterial activities and expedited wound healing. Zhang et al [133] developed ZnO-incorporated chitin-based hydrogels with a one-pot, environment-friendly, and efficient strategy. The chitin/ZnO composite hydrogels exhibit excellent antibacterial activity and acceptable biocompatibility, and accelerate healing of infectious full-thickness wounds.…”

Section: Metal Oxide Nanoparticlesmentioning

confidence: 99%

Inorganic-Nanomaterial-Composited Hydrogel Dressings for Wound Healing

Yang,

Wang,

Zhang

et al. 2024

J. Compos. Sci.

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Wound management heavily relies on the vital contribution of wound dressings, emphasizing the significance of finding an ideal dressing that can fulfill the intricate requirements of the wound healing process with multiple functions. A promising strategy is combining several materials and therapies to create multifunctional wound dressings. Nanocomposite hydrogel dressings based on nanomaterials, combining the advantages of nanomaterials and hydrogels in wound treatment, can significantly improve their respective performance and compensate for their shortcomings. A variety of nanocomposite wound dressings with diverse structures and synergistic functions have been developed in recent years, achieving ideal results in wound management applications. In this review, the multiple functions, advantages, and limitations of hydrogels as wound dressings are first discussed. Additionally, the application of inorganic nanomaterials in wound healing is also elaborated on. Furthermore, we focused on summarizing and analyzing nanocomposite hydrogel dressings for wound healing, which contain various inorganic nanomaterials, including metals, metal oxides, metal sulfides, carbon-based nanomaterials, and silicon-based nanoparticles. Finally, prospects for nanocomposite hydrogel wound dressings are envisaged, providing insights for further research in wound management.

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“…Metallic nanoparticles possess a range of advantages such as broad antibacterial spectrum, high antibacterial activities, good biocompatibilities, durable stabilities and non-resistance. Silver [124][125][126][127], gold [127][128][129], copper oxide [130][131][132], zinc oxide [133][134][135], iron oxide [136][137][138], titanium dioxide [139][140][141], and magnesium oxide nanoparticles [142][143][144] have all been frequently documented as antibacterial substances. The antibacterial mechanism of these nanoparticles is mainly: 1. electrostatic adsorption and influences the bacterial membrane and cell wall function; 2. the destruction of bacterial enzymes, proteins, and DNA structure.…”

Section: The Antimicrobial Mechanisms Of Metallic Nanoparticlesmentioning

confidence: 99%

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

Jiang¹,

Ding²,

Liu³

2023

Theranostics

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Pathogenic bacterial infections represent an ever-growing crisis, now significantly threatening life expectancy across the worldwide population and thus novel approaches to tackle this issue are urgently needed. The application of nanotechnology in recent years has opened up new horizons in the selective or specific delivery of drugs or imaging agents to infectious sites. In particular, the development of nanoparticles for both delivery of active substances and imaging of infection sites is now gathering much interest. Although still in its infancy, the field of antibacterial nanomedicines provides exciting new possibilities to combat multi-resistant bacterial infections and shows great promise for personalized medicine in antibacterial stewardship. This review examines nanoparticle-based formulations used for therapeutic delivery, pathogen tracking in diagnosis, and combined “theranostic” approaches to more effectively treating bacterial infections.

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Facile fabrication of chitin/ZnO composite hydrogels for infected wound healing

Abstract: When ordinary wounds are infected, the skin’s self-healing capacity declines, thus appropriate dressings with both of the antibacterial ability and the ability to facilitate healing for bacteria-associated wounds are indispensable....

Cited by 17 publications

References 49 publications

ZnO-incorporated chitin hydrogels for infected wound therapy

ZnO-incorporated chitin hydrogels for infected wound therapy

Inorganic-Nanomaterial-Composited Hydrogel Dressings for Wound Healing

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

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