Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles

Abstract

Disulfide bond has emerged as a promising redox-sensitive switch for smart polymeric micelles, due to the properties of rapid response to the reductive environment and spatiotemporally control therapeutic agent delivery....

Effects of oppositely charged moieties on the self-assembly and biophysicochemical properties of polyurethane micelles

“…S3, ESI†), implying that the longer hydrophilic mPEG chain accelerated the degradation process due to the disproportionate hydrophobic/hydrophilic ratio in the broken chain, which is consistent with our previous report. 43…”

“…S3, ESI †), implying that the longer hydrophilic mPEG chain accelerated the degradation process due to the disproportionate hydrophobic/hydrophilic ratio in the broken chain, which is consistent with our previous report. 43 Drug loading and release studies Paclitaxel (PTX) shows excellent antitumor activity in many tumors, but its poor water solubility limits its widespread clinical applications. Thus, ethanol and Cremophor EL are usually used as pharmaceutical excipients to improve its water solubility, but they lead to some major side effects.…”

Approved Nanomedicine against Diseases

“…The hydrophobic core encapsulates drugs with low water solubility; as for the hydrophilic shell, it protects cargos and maintains the stability of the micelles [ 155 ]. The commonly used hydrophobic polymers [ 156 , 157 , 158 ] include polylactic acid (PLA), polylactide glycolide acid (PLGA), and polyamine acid (PAA), while the commonly used hydrophilic polymers are PEG, chitosan, hyaluronic acid (HA) and PVP [ 159 , 160 , 161 ]. The design of polymeric micelles aims to encapsulate active compounds to protect them from the external environment, improve their pharmacokinetic profile, and reduce the side effect [ 162 , 163 ].…”

Synthesis and in vitro antitumor activity of galactosamine–docetaxel conjugates

“…Both diselenide and disulfide bonds are reported to exhibit reductionresponsiveness, enabling selective drug release in tumor cells with elevated GSH levels (Zhou et al, 2023). These three conjugates were well-characterized by using spectroscopic methods (Ma et al, 2022;Pan et al, 2022;Singh et al, 2017;Sun et al, 2022;Zhao et al, 2021;Zhu et al, 2022). Subsequently, the in vitro drug release, cell cycle, cell apoptosis, and in vitro anticancer effects of these conjugates were studied.…”