Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia

Zhang, Shi‐Jin; Chen, Zhuo; Li, Guowen; Wang, Boliang

doi:10.1016/s1995-7645(13)60113-3

Cited by 12 publications

(10 citation statements)

References 8 publications

(9 reference statements)

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“…Shengjiang Power can increase the percentage of CD8+ in peripheral blood, regulate the radio of CD4+/CD8+, and improve the immune function of the body (p<0.05 or p<0.01) (Nan et al, 2016b). Other study results have shown that compared with ribavirin, the Haoqin Qingdan Decoction can improve the ratio of T lymphocyte subgroup and Th1/Th2 cell balance more effectively in rats with damp-heat syndrome of influenza viral pneumonia (Zhang et al, 2013).…”

Section: Regulation Of Lymphocyte Subsetsmentioning

confidence: 96%

Role of Traditional Chinese Medicine in the Management of Viral Pneumonia

Yue

et al. 2020

Front. Pharmacol.

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Viral pneumonia is one kind of acute respiratory tract infection caused by the virus. There have been many outbreaks of viral pneumonia with high contagiousness and mortality both in China and abroad, such as the great influenza in 1918, the severe acute respiratory syndrome (SARS) coronavirus in 2003, the Influenza A (H1N1) virus in 2009, and the Middle East Respiratory Syndrome coronavirus (MERS-CoV) in 2012 and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019. These outbreaks and/ or pandemic have significant impact on human life, social behaviors, and economic development. Moreover, no specific drug has been developed for these viruses. Traditional Chinese medicine (TCM) plays an important role in the treatment of viral pneumonia during these outbreaks especially in SARS and SARS-CoV-2 because studies suggest that TCM formulations may target several aspects of the disease and may have lesser side effects than manufactured pharmaceuticals. In recent years, a lot of clinicians and researchers have made a series of in-depth explorations and investigations on the treatment of viral pneumonia with TCM, which have understood TCM therapeutic mechanisms more specifically and clearly. But critical analysis of this research in addition to further studies are needed to assess the potential of TCM in the treatment of viral pneumonia.

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Section: Regulation Of Lymphocyte Subsetsmentioning

confidence: 96%

Role of Traditional Chinese Medicine in the Management of Viral Pneumonia

Yue

et al. 2020

Front. Pharmacol.

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“…For example, multiple ingredients from Chinese herbs counteract chemotherapy-induced gastrointestinal toxicity and kansui-induced hepatocyte cytotoxicity [ 10 , 11 ]. Haoqin Qingdan decoction (HQQD), a traditional Chinese formula widely used for the treatment of different diseases [ 12 , 13 ], consists of herbal materials of Artemisinin , bamboo shavings, Pinellia ternata , Indian buead , Scutellaria baicalensis , Aurantii fructus , Aurantii nobilis pericarpium , and Biyu powder. Although there are a lot of researches regarding HQQD, few of them are involved in the hepatotoxicity induced by CP.…”

Section: Introductionmentioning

confidence: 99%

The Hepatoprotective Effect of Haoqin Qingdan Decoction against Liver Injury Induced by a Chemotherapeutic Drug Cyclophosphamide

Jia

2015

Evidence-Based Complementary and Alternative Medicine

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Haoqin Qingdan decoction (HQQD), a modern Chinese formula, has been widely used in Eastern Asia. Our study focuses on the hepatoprotective effect of HQQD against cyclophosphamide-induced hepatotoxicity. S180, a kind of ascites tumor cells, was used to establish S180-bearing mice, followed by the injection of cyclophosphamide (CP, 80 mg/kg) every other day for 5 times. HQQD was used intragastrically at the dose of 80 g/kg, 40 g/kg, and 20 g/kg twice a day for 12 days. HL-7702 hepatic cell line was incubated with HQQD-medicated serum. Then we detected the effects of HQQD on (i) tumor suppression; (ii) morphological examination; (iii) SOD, MDA, GSH, ALT, and AST; (iv) cleaved caspase-3 expression and (v) cellular viability. CP caused dramatic elevations of AST, ALT, and MDA, while HQQD notably attenuated these elevations. SOD and GSH were notably increased, which were efficiently attenuated by HQQD. CP injection significantly increased apoptosis by increasing cleaved caspase-3 expression, which was obviously inhibited by HQQD, accompanied by the improvement of cells viability. Histopathological examinations supported the above findings. Therefore, HQQD may protect liver tissue through attenuating oxidative stress and the caspase-3-dependent intrinsic apoptosis induced by CP, which suggests the potentially therapeutic effect of HQQD in the use of alkylating agent for cancer chemotherapy.

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“…HQD was generated as described by Zhang, et al (5) The main components in HQD were as follows: Artemisia carvifolia 10 g, Pinellia ternata Breit 10 g, Citrus aurantium L. 10 g, Caulis Bambusae in Taeniam 10 g, Scutellaria baicalensis 15 g, Isatis indigotica Fortune 15 g, Isatis tinctoria 15 g, Glycyrrhiza uralensis Fisch. 6 g, Citrus reticulata Blanco.…”

Section: Experimental Materialsmentioning

confidence: 99%

“…inducing factor in FDDHS. (5) The toll-like receptor (TLR) 2 and nuclear factor (NF)-κB expression decreased in DHS mice during HQD therapy. (7) We hypothesized that innate immunity might mediate the progression and treatment of DHS.…”

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confidence: 99%

Haoqin Qingdan Decoction (蒿芩清胆汤) and ribavirin therapy downregulate CD14 and toll-like receptor 4 in febrile disease with dampness-heat syndrome in a mouse model

Luo

Zhang

Wu³

et al. 2016

Chin. J. Integr. Med.

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Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia

Abstract: Compared with ribavirin, the high dose Haoqinqingdan decoction can improve the ratio of T lymphocyte subgroup and Th1/Th2 cell balance more effectively.

Cited by 12 publications

References 8 publications

Role of Traditional Chinese Medicine in the Management of Viral Pneumonia

Role of Traditional Chinese Medicine in the Management of Viral Pneumonia

The Hepatoprotective Effect of Haoqin Qingdan Decoction against Liver Injury Induced by a Chemotherapeutic Drug Cyclophosphamide

Haoqin Qingdan Decoction (蒿芩清胆汤) and ribavirin therapy downregulate CD14 and toll-like receptor 4 in febrile disease with dampness-heat syndrome in a mouse model

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