Highlights d Activated Gasdermin D forms mitochondrial pores in the endothelium d Mitochondrial pore formation releases mitochondrial DNA into the cytosol d Released mtDNA activates cGAS signaling and suppresses vascular regeneration d Deletion of cGAS in an experimental model of polymicrobial sepsis reduces tissue injury
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.