Effect of the hyaluronic acid‐poloxamer hydrogel on skin‐wound healing: in vitro and in vivo studies

Li, Xiaojuan; Li, Aimin; Feng, Fan; Jiang, Qiyu; Sun, Hongbin; Chai, Yantao; Yang, Ruihua; Wang, Zhijie; Hou, Jun; Li, Ruisheng

doi:10.1002/ame2.12067

Cited by 43 publications

(25 citation statements)

References 52 publications

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“…However, when applied to the wound, hyaluronic acid has the disadvantage of reduced wound breathability [115]. In order to overcome this drawback, a hydrogel composed of hyaluronic acid and poloxamer was developed and studied, revealing excellent results in terms of air permeability, promoting skin-wound healing and increasing protein accumulation, and isolating skin wounds from bacterial invasion [116]. The use and effectiveness of hyaluronic acid as a coating material of micro-and nanoparticles in wound care was already studied and proved [117][118][119].…”

Section: Natural Versus Synthetic Polymers For Polyphenol Carrier Designmentioning

confidence: 99%

Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care

et al. 2021

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In chronic wounds, the regeneration process is compromised, which brings complexity to the therapeutic approaches that need to be adopted, while representing an enormous loss in the patients’ quality of life with consequent economical costs. Chronic wounds are highly prone to infection, which can ultimately lead to septicemia and morbidity. Classic therapies are increasing antibiotic resistance, which is becoming a critical problem beyond complex wounds. Therefore, it is essential to study new antimicrobial polymeric systems and compounds that can be effective alternatives to reduce infection, even at lower concentrations. The biological potential of polyphenols allows them to be an efficient alternative to commercial antibiotics, responding to the need to find new options for chronic wound care. Nonetheless, phenolic compounds may have some drawbacks when targeting wound applications, such as low stability and consequent decreased biological performance at the wound site. To overcome these limitations, polymeric-based systems have been developed as carriers of polyphenols for wound healing, improving its stability, controlling the release kinetics, and therefore increasing the performance and effectiveness. This review aims to highlight possible smart and bio-based wound dressings, providing an overview of the biological potential of polyphenolic agents as natural antimicrobial agents and strategies to stabilize and deliver them in the treatment of complex wounds. Polymer-based particulate systems are highlighted here due to their impact as carriers to increase polyphenols bioavailability at the wound site in different types of formulations.

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Section: Natural Versus Synthetic Polymers For Polyphenol Carrier Designmentioning

confidence: 99%

Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care

et al. 2021

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“…Of note, several studies demonstrated local tolerance to p407 poloxamer hydrogel when tested on the skin, including the burnt skin [ 22 , 34 ]. Moreover, a number of studies used a poloxamer hydrogel as a vehicle for bioactive molecules aimed at promoting skin healing [ 21 , 34 , 35 , 36 , 37 , 38 ]. These various studies highlighted the value of using a poloxamer hydrogel as a delivery system for an active ingredient.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a Topically Testable Model of Burn Injury on Human Skin Explants

Gross-Amat

Guillen

Salmon

et al. 2020

IJMS

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Severe burn injuries remain a major health problem due to high rates of mortality, residual morbidity, and/or aesthetic damages. To find new therapies aimed at promoting a harmonious healing of skin burns, it is important to develop models which take into account the unique properties of the human skin. Based on previously described models of burn injury performed on human skin explants, we hypothesized that maintaining explants under constant tension forces would allow to more closely reproduce the pathophysiological processes of skin remodeling. We thus. Here, we set up and characterized an improved model of deep second-degree burn injury on ex vivo cultured human skin explants at air-liquid interface and maintained under conditions of constant tension forces. A spontaneous re-epithelialization of the lesion was observed 8 to 9 days post burn and was found to rely on the proliferation of basal keratinocytes at the wound edges. Collagen VII at the dermo-epidermal junction reformed along with the progression of re-epithelializatio and a synthesis of procollagen III was observed in the dermis at the wound site. These findings indicate that our model is suitable for the assessment of clinically-relevant therapies aimed at modulating the kinetics of re-epithelialization and/or the activation of fibroblasts following skin burn injuries. In this regard, we evaluated the use of a thermoreversible poloxamer hydrogel as a vehicle for topically-testable therapeutic molecules. Our data showed that, although useful for drug formulation, the p407/p188 poloxamer hydrogel induces a delay of skin re-epithelialization in humans skin explants submitted to experimental burn injury.

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“…The new material was also effective in promoting skin wound healing [ 57 ] by enhancing protein accumulation in the wound area, increasing permeability, and preventing bacterial invasion. In addition, its effective moisturizing and breathability ability helps to prevent wound infection and protects the wound, thus avoiding the need for antibiotics [ 58 ].…”

Section: Subjectsmentioning

confidence: 99%

An Overview on Thermosensitive Oral Gel Based on Poloxamer 407

et al. 2021

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In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in medicine, especially for oral cavities. Thermosensitive hydrogels remain fluid at room temperature; at body temperature, they become more viscous gels. In this manner, the gelling system can remain localized for considerable durations and control and prolong drug release. The chemical structure of the poloxamer triblock copolymer leads to an amphiphilic aqueous solution and an active surface. Moreover, the poloxamer can gel by forming micelles in an aqueous solution, depending on its critical micelle concentration and critical micelle temperature. Owing to its controlled-release effect, a thermosensitive gel based on poloxamer 407 (P407) is used to deliver drugs with different characteristics. As demonstrated in studies on poloxamer formulations, an increase in gelling viscosity decreases the drug release rate and gel dissolution time to the extent that it prolongs the drug’s duration of action in disease treatment. This property is used for drug delivery and different therapeutic applications. Its unique route of administration, for many oral diseases, is advantageous over traditional routes of administration, such as direct application and systemic treatment. In conclusion, thermosensitive gels based on poloxamers are suitable and have great potential for oral disease treatment.

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Effect of the hyaluronic acid‐poloxamer hydrogel on skin‐wound healing: in vitro and in vivo studies

Cited by 43 publications

References 52 publications

Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care

Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care

Characterization of a Topically Testable Model of Burn Injury on Human Skin Explants

An Overview on Thermosensitive Oral Gel Based on Poloxamer 407

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