Effect of the IL-6 promoter polymorphism -174 G/C on risk and outcome of pneumonia

Martín‐Loeches, Ignacio; Violan, J. Sole; Blanquer, José; Aspa, Javier; Gallego, C. Rodríguez; Castro, Felipe Rodrı́guez de; Laorden, I García; Rajas, Olga; Garcia-Saavedra, Ayoze

doi:10.1186/cc6686

Cited by 5 publications

(4 citation statements)

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“…As pointed out above, serum levels of IL-6 are well known to be involved in sepsis pathogenesis and take part in the systemic response to infection [11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…Among these cytokines, IL-6 is considered to play an important role in the evolution of sepsis, especially as an early indicator of the inflammatory state [14][15][16][17][18]. Several studies have detected nucleotide changes in the gene that codes for IL-6, generating polymorphisms that would be related to risk factors or protectors to develop sepsis, septic shock and even death due to sepsis [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Vivas

Guerrero

Tascón

et al. 2021

IMAS

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In this study, IL-6 levels were assessed as inflammatory biomarker of bacterial sepsis in patients hospitalized at the ICU of the hospital of Colombia.Materials and methodsProspective study on 62 patients diagnosed with sepsis and septic shock. An ELISA assay was used to test serum levels of IL-6 at admission and 48 h after admission. Variables were analyzed by χ2 test (alfa <0.05). Multivariable Cox regression was used to determine the survival with the statistical program SPSS v23.00.ResultsPatient's median age was 53 years old and 59.7% were male. Lung was the most common primary site of infection (43.5%), and hypertension comorbidity with higher prevalence (40%). Infection by Gram negative bacteria were significantly more frequent among patients than Gram positive (P = 0.037). Overall, survival analysis showed that 10 (16.1%) patients died with a survival median of 7.00 +4.874 (2–3) days. In patients with sepsis we detected a significant decline in the average of IL-6 serum levels after 48 h of admission [7.50 (SD: 7.00–68.00) pg/mL vs. 68.00 [SD: 7.00–300.00] pg/mL (P = 0.000). Only 25% of patients with septic shock who presented high levels of IL-6 at the time of admission and at 48 h had a survival up to 15 days (P = 0.005).ConclusionWe found significant differences between the plasma levels of IL-6 during the first 48 h after admission to the ICU among patients with sepsis and septic shock. Patients with sepsis had a significant decline in IL-6 levels, whereas in patients who developed septic shock, levels of this cytokine remained high and have a lower survival compared to those who maintained low levels of IL-6.

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“…As pointed out above, serum levels of IL-6 are well known to be involved in sepsis pathogenesis and take part in the systemic response to infection [11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Vivas

Guerrero

Tascón

et al. 2021

IMAS

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“…Las citocinas se consideran mensajeras fisiológicas de la respuesta inmune, son activas en bajas concentraciones y se unen a receptores específicos en diferentes células, lo que ocasiona la liberación de mediadores secundarios y de otras citocinas, así como la expresión de múltiples moléculas que permiten la activación de diferentes poblaciones celulares (6)(7)(8)(9)43). Diversos estudios han relacionado la presencia de ciertos polimorfismos en los genes que las codifican con la susceptibilidad a infecciones, las diferentes formas clínicas de la sepsis y la mortalidad (44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57).…”

Section: Polimorfismos Estudiados En Citocinasunclassified

“…En esta misma investigación, los pacientes que fallecieron tenían niveles séricos de IL-6, es decir, significativamente superiores comparados con los de aquellos pacientes que sobrevivieron (genotipo GG) (49). Estos resultados fueron concordantes con los obtenidos en un estudio realizado en un hospital alemán, en los que los pacientes portadores del genotipo homocigoto GG se asociaron con una mejora de la supervivencia en la sepsis en forma significativa (50).…”

Section: Il-6unclassified

Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock

2020

SRP

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Contribution of genes polymorphism to susceptibility and outcome of sepsis

Harapan

Jamil

2010

Egyptian Journal of Medical Human Genetics

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Effect of the IL-6 promoter polymorphism -174 G/C on risk and outcome of pneumonia

Cited by 5 publications

References 1 publication

Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock

Contribution of genes polymorphism to susceptibility and outcome of sepsis

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