Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Vivas, Mónica Chávez; Guerrero, Hector Fabio Villamarin; Tascón, Antonio José; Valderrama-Aguirre, Augusto

doi:10.1556/1646.2020.00006

Cited by 11 publications

(9 citation statements)

References 40 publications

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“…Serum levels of IL-6 are well known to be involved in sepsis pathogenesis and take part in the systemic response to infection. 22 In this study, there was no difference in serum level of IL-6 in sepsis cases (mean= 203 pg/ml) compared to control group (mean= 101 pg/ml). In contrary, Song et al, 2019 and Smok et al, 2020 found a significant increase in IL-6 in sepsis patients.…”

Section: Discussioncontrasting

confidence: 50%

“…2021 did not find a significant correlation between serum levels of IL-6 and sepsis outcome in terms of mortality. 22 Takahashi et al, 2016 showed that serum IL-6 levels were significant predictors of 28-day mortality and their prognostic value increased over time up to 7 days. 25 On the contrary, Carta et al, 2016 showed elevated serum IL-6 was associated with non-survivors.…”

Section: Il-6 Mirna 15amentioning

confidence: 99%

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Serum level of MicroRNA 15a and interleukin 6 as biomarkers for sepsis in critically Ill Patients

Nader

Abdelmaseeh

Sharif

et al. 2023

EJI

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This study intended to evaluate the diagnostic efficacy of serum interleukin-6 (IL-6) and serum expression level of microRNA 15a (miRNA 15a) in sepsis patients admitted to the medical intensive care unit (ICU), and to correlate the results with the outcome of patients. This observational case-control study, was done from January 2022 to June 2022, included 75 adult ICU patients ≥18 years old, divided into 2 groups. Group 1: included 38 adults, critically ill sepsis patients and Group 2 (control group), included 37 adults, non-sepsis patients admitted to the ICU. Venous blood was withdrawn from cases and controls under aseptic conditions for assessment of serum IL-6 level by ELISA and serum expression level of miRNA 15a by quantitative reverse transcriptase real-time polymerase chain reaction (qRT-PCR). Patient demographic data in addition to their characteristics including site of infection, blood culture results, length of stay and outcome of patients were included in the study. miRNA 15a was significantly higher in the sepsis group with mean of 3.99±1.61 compared to the controls (1.03±0.03, p< 0.001) while serum IL-6 levels were higher in the sepsis patients compared to the controls, however the difference did not reach statistical significance (p= 0.92). No difference was found in IL-6 and miRNA 15a levels between surviving and non-surviving sepsis patients, shocked and non-shocked sepsis patients. In conclusion, both IL-6 and miRNA 15a were up-regulated in ICU patients with sepsis. Both biomarkers did not show a significant difference regarding the outcome of patients. miRNA 15a could be considered a highly speciﬁc and sensitive marker in differentiating sepsis cases from controls, so it could be used as a diagnostic rather than a prognostic biomarker for sepsis.

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Section: Discussioncontrasting

confidence: 50%

Section: Il-6 Mirna 15amentioning

confidence: 99%

Serum level of MicroRNA 15a and interleukin 6 as biomarkers for sepsis in critically Ill Patients

Nader

Abdelmaseeh

Sharif

et al. 2023

EJI

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“…Damit ist die Kinetik von Interleukin-6 deutlich schneller als beim CRP und PCT, die eine "Response"-Halbwertszeit von 6-8 h bis zum Anstieg aufweisen [30]. Darüber hinaus kann IL-6 zur Prognoseabschätzung genutzt werden [30,31].…”

Section: Merkeunclassified

Fieber in der Intensivmedizin

Naendrup¹,

Böll²,

Borrega³

2023

Intensivmedizin up2date

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Fieber ist ein sehr häufiges, dabei unspezifisches Symptom auf der Intensivstation, kann ganz verschiedene Ursachen haben und ist assoziiert mit einem schlechteren Outcome. Insofern muss jedes Fieber auf der Intensivstation abgeklärt werden, und das Temperaturmanagement richtet sich nach Grunderkrankung, klinischem Zustand des Patienten bzw. der Patientin und evtl. unerwünschten Wirkungen der Therapiemaßnahmen.

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“…Moreover, the onset of inflammatory response, termination, and transition to the homeostasis after sepsis are ATP demanding processes and require biosynthetic precursors provided by metabolic pathways. While studies have shown that an altered inflammatory response in the acute and prolonged phases of sepsis is tightly connected with impaired immune cells metabolism and unfavorable outcomes, the mechanistic mediators of this misconnection are not completely elucidated yet (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

“…The early-onset activation of innate immune cells after infection releases proinflammatory cytokines that further mediate responses in the target tissues and in adaptive immune cells like lymphocytes (3). In this context, proinflammatory cytokines, like IL-1 β and IL-6, seem to exert a primary role in mediating (4) autocrine and paracrine signaling, with reflections on biosynthetic pathways (5)(6)(7)(8)(9). For instance, an increase in IL-6 stimulates the liver synthesis of reactant C-reactive protein (CRP), a pro-and anti-inflammatory effector (10,11).…”

Section: Introductionmentioning

confidence: 99%

Short-Term Inflammatory Biomarker Profiles Are Associated With Deficient Mitochondrial Bioenergetics in Lymphocytes of Septic Shock Patients—a Prospective Cohort Study

Nedel¹,

Strogulski

Rodolphi

et al. 2022

Shock

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Introduction: A biomarker strategy based on the quantification of an immune profile could provide a clinical understanding of the inflammatory state in patients with sepsis and its potential implications for the bioenergetic state of lymphocytes, whose metabolism is associated with altered outcomes in sepsis. The objective of this study is to investigate the association between mitochondrial respiratory states and inflammatory biomarkers in patients with septic shock. Methods: This prospective cohort study included patients with septic shock. Routine, complex I, complex II respiration, and biochemical coupling efficiency were measured to evaluate mitochondrial activity. We measured IL-1ß, IL-6, IL-10, total lymphocyte count, and C-reactive protein levels on days 1 and 3 of septic shock management as well as mitochondrial variables. The variability of these measurements was evaluated using delta counts (days 3–1 counts). Results: Sixty-four patients were included in this analysis. There was a negative correlation between complex II respiration and IL-1ß (Spearman ρ, −0.275; P = 0.028). Biochemical coupling efficiency at day 1 was negative correlated with IL-6: Spearman ρ, −0.247; P = 0.05. Delta complex II respiration was negatively correlated with delta IL-6 (Spearman ρ, −0.261; P = 0.042). Delta complex I respiration was negatively correlated with delta IL-6 (Spearman ρ, −0.346; P = 0.006), and delta routine respiration was also negatively correlated with both delta IL-10 (Spearman ρ, −0.257; P = 0.046) and delta IL-6 (Spearman ρ, −0.32; P = 0.012). Conclusions: The metabolic change observed in mitochondrial complex I and complex II of lymphocytes is associated with a decrease in IL-6 levels, which can signal a decrease in global inflammatory activity.

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Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

Cited by 11 publications

References 40 publications

Serum level of MicroRNA 15a and interleukin 6 as biomarkers for sepsis in critically Ill Patients

Serum level of MicroRNA 15a and interleukin 6 as biomarkers for sepsis in critically Ill Patients

Fieber in der Intensivmedizin

Short-Term Inflammatory Biomarker Profiles Are Associated With Deficient Mitochondrial Bioenergetics in Lymphocytes of Septic Shock Patients—a Prospective Cohort Study

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