Effect of the ingestion of vegetable oils associated with energy-restricted normofat diet on intestinal microbiota and permeability in overweight women

Cândido, Thalita Lin Netto; Silva, Laís Emilia da; Cândido, Flávia Galvão; Valente, Flávia Xavier; Silva, Juliana Soares da; Lopes, Déborah Romaskevis Gomes; Pelúzio, Maria do Carmo Gouveia; Mantovani, Hilário Cuquetto; Alfenas, Rita de Cássia Gonçalves

doi:10.1016/j.foodres.2020.109951

Cited by 9 publications

(15 citation statements)

References 51 publications

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“…Nine studies analyzed the effects of coconut oil on body weight [ 16 – 18 , 26 , 39 , 42 , 43 , 46 , 51 ]. These studies included 533 participants (56.5% females, 18 to 68 years).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies [ 16 , 17 , 39 , 42 , 43 , 51 ] were included in the meta-analysis. Overall, weight loss was similar for those receiving coconut oil in comparison to those receiving other oils or fat (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The studies were performed in Europe (n = 2), Asia (n = 3), New Zealand (n = 1), the United States of America (n = 7), and Brazil (n = 4). In four studies, coconut oil was compared predominantly to MUFAs (olive and canola) [39][40][41][42], in 11 studies predominantly to PUFAs (soybean, chia, safflower, sunflower, and corn) [16,17,26,[42][43][44][45][46][47][48][49], and in six studies predominantly to SFAs (lard, butter, and palm oil) [39,40,44,50,51], followed by comparisons with soybean oil + psyllium, transgenic soybean, hydrogenated soybean, and a placebo in one study each [18,26,45,50]. The amount of coconut oil consumed varied and is expressed differently among studies (Table 1): 12 to 30 ml of coconut oil/day (n = 5), as part of the amount of SFAs or total daily consumed fat (n = 1), a variation of 6 to 54.4 g/day (n = 5), or as part of the total caloric energy intake (15 to 21%) (n = 6).…”

Section: Resultsmentioning

confidence: 99%

“…An increase in plasmatic levels of HDL-C was observed with coconut oil intake compared with other oils while analyzing different studies (Fig. 3 b), which could be explained by the fact that, in most of those studies, participants were exposed to co-interventions, including diet [ 16 , 42 , 43 , 49 , 51 ] and physical activity [ 16 , 43 ] – which may have a significant impact on HDL-C levels [ 58 , 59 ]. In fact, in one of these studies, participants significantly lost more weight, and, in two of them, there was a greater reduction in waist circumference with coconut oil compared to soybean oil.…”

Section: Discussionmentioning

confidence: 99%

“…We contacted the authors of crossover studies and received these data from the authors of one study, which we included in our analysis [ 51 ]. In addition to that, we included two new RCTs [ 42 , 49 ] that had not been included in the most recent meta-analysis [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

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The effects of coconut oil on the cardiometabolic profile: a systematic review and meta-analysis of randomized clinical trials

et al. 2022

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Background Despite having a 92% concentration of saturated fatty acid composition, leading to an apparently unfavorable lipid profile, body weight and glycemic effect, coconut oil is consumed worldwide. Thus, we conducted an updated systematic review and meta-analysis of randomized clinical trials (RCTs) to analyze the effect of coconut oil intake on different cardiometabolic outcomes. Methods We searched Medline, Embase, and LILACS for RCTs conducted prior to April 2022. We included RCTs that compared effects of coconut oil intake with other substances on anthropometric and metabolic profiles in adults published in all languages, and excluded non-randomized trials and short follow-up studies. Risk of bias was assessed with the RoB 2 tool and certainty of evidence with GRADE. Where possible, we performed meta-analyses using a random-effects model. Results We included seven studies in the meta-analysis (n = 515; 50% females, follow up from 4 weeks to 2 years). The amount of coconut oil consumed varied and is expressed differently among studies: 12 to 30 ml of coconut oil/day (n = 5), as part of the amount of SFAs or total daily consumed fat (n = 1), a variation of 6 to 54.4 g/day (n = 5), or as part of the total caloric energy intake (15 to 21%) (n = 6). Coconut oil intake did not significantly decrease body weight (MD -0.24 kg, 95% CI -0.83 kg to 0.34 kg), waist circumference (MD -0.64 cm, 95% CI -1.69 cm to 0.41 cm), and % body fat (-0.10%, 95% CI -0.56% to 0.36%), low-density lipoprotein cholesterol (LDL-C) (MD -1.67 mg/dL, 95% CI -6.93 to 3.59 mg/dL), and triglyceride (TG) levels (MD -0.24 mg/dL, 95% CI -5.52 to 5.04 mg/dL). However, coconut oil intake was associated with a small increase in high-density lipoprotein cholesterol (HDL-C) (MD 3.28 mg/dL, 95% CI 0.66 to 5.90 mg/dL). Overall risk of bias was high, and certainty of evidence was very-low. Study limitations include the heterogeneity of intervention methods, in addition to small samples and short follow-ups, which undermine the effects of dietary intervention in metabolic parameters. Conclusions Coconut oil intake revealed no clinically relevant improvement in lipid profile and body composition compared to other oils/fats. Strategies to advise the public on the consumption of other oils, not coconut oil, due to proven cardiometabolic benefits should be implemented. Registration PROSPERO CRD42018081461.

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“…Nine studies analyzed the effects of coconut oil on body weight [ 16 – 18 , 26 , 39 , 42 , 43 , 46 , 51 ]. These studies included 533 participants (56.5% females, 18 to 68 years).…”

Section: Resultsmentioning

confidence: 99%