Effect of the Interaction of Veratrum Nigrum with Panax Ginseng on Estrogenic Activity In Vivo and In Vitro

Xu, Ying; Ding, Jie; An, Jin-na; Qu, Ya‐kun; Li, Xin; Ma, Xiaoping; Zhang, Yimin; Dai, Guo-jing; Lin, Na

doi:10.1038/srep26924

Cited by 21 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, previous studies have reported that large doses of GS inhibit the activity of mice (48,49). Second, aside from their appetite, mice exhibit reduced consumption and exercise levels naturally (50,51). in conclusion, GS increase the basal metabolic rate of mice to enhance fat mobilization and thereby reduce weight.…”

Section: Effect Of Gs On Metabolic Measuresmentioning

confidence: 78%

See 1 more Smart Citation

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Yao

2020

Mol Med Report

View full text Add to dashboard Cite

obesity has been increasing globally for over three decades. according to previous studies, dietary obesity is usually associated with endoplasmic reticulum stress (erS) and STaT3 signaling, which result in interference with the homeostatic control of energy and lipid metabolism. Ginsenosides (GS) administered to mice will modulate adiposity and food intake; however, the mechanism of food inhibition is unknown. The aim of the present study was to investigate whether GS may inhibit erS and regulate STaT3 phosphorylation in GT1-7 cells (a mouse hypothalamus gonadotropin-releasing hormone neuron cell line) and the hypothalamus in order to reduce the body weight and ameliorate hepatic steatosis in high fat diet (HFd)-induced obese mice. in the present study, GS inhibited the appetite, reduced the body weight, visceral fat, body fat content and blood glucose, and ameliorated the glucose tolerance of the obese mice compared with HFd mice. in addition, the levels of aspartate aminotransferase and alanine aminotransferase, triglyceride (TG), leptin and insulin in the serum were reduced compared with HFd mice. There was less TG in the liver, but more in the feces compared with HFd mice. using hematoxylin and eosin staining of HepG2 cells and liver tissues, GS were demonstrated to improve the non-alcoholic fatty liver of the HFd-induced obese mice and reduce the diameter of the fat cells compared with HFd mice. GS also increased oxygen consumption and carbon dioxide emissions in the metabolic cage data compared with HFd mice. in the GT1-7 cells, GS alleviated the erS induced by tunicamycin and enhanced the activation of the STaT3 phosphorylation pathway. Furthermore the erS of the liver was relieved to achieve the aforementioned pharmacological effects. GS were used in the homeostatic control of the energy and lipid metabolism of a diet-induced obesity model. in conclusion, present studies suggest that GS exert these effects by increasing STaT3 phosphorylation expression and reducing the erS. Thus, GS reduce body weight and ameliorate hepatic steatosis in HFd-induced obese mice.

show abstract

Section: Effect Of Gs On Metabolic Measuresmentioning

confidence: 78%

“…china was the first country globally to use and record ginseng in medical literature. Ginseng has been recorded in chinese medical literature for >2,000 years (51). GS are regarded as the main active ingredient in ginseng, thus becoming the point of focus in research (52).…”

Section: Discussionmentioning

confidence: 99%

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Yao

2020

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…However, based on the records of Chinese medical applications, the use of ginseng together with some specific herbs such as Veratrum nigrum L. should be avoided altogether as it can reduce or even reverse the therapeutic function of ginseng. Such interactions have recently been supported by scientific evidence [76]. There are also some other descriptions of interactions between ginseng and food in Chinese practice, for instance, the consumption of radish (Raphanus sativus L.) may reduce the nourishing effect of ginseng.…”

Section: Interactions Of Ginseng With Other Drugsmentioning

confidence: 80%

“…Inhibits production of NO, ROS, TNF-α; inhibits expression of NF-κB, IRF-1, STAT1, JAK1, STAT1, STAT3, ERK [74,76]…”

Section: Rh1mentioning

confidence: 99%

The Difference between White and Red Ginseng: Variations in Ginsenosides and Immunomodulation

Huang

Liu

et al. 2018

Planta Med

View full text Add to dashboard Cite

Ginseng Radix () is one of the most commonly used herbs worldwide for the treatment of inflammation-related diseases among others, supported by ancient historical records. Throughout this long history, the large-scale cultivation of ginseng created an increasing demand for long-term storage of the harvested plant material, accelerating the development of post-harvesting procedures. Dried white ginseng and processed (steamed) red ginseng are the products of the two most common traditional post-harvest processes. Although there are a significant number of reports on practice-based therapeutic applications of ginseng, science-based evidence is needed to support these uses. Using a reverse pharmacology approach in conjunction with high-throughput techniques and animal models may offer clear, simple paths for the elucidation of the mechanisms of activity of herbal medicines. Moreover, it could provide a new and more efficient method for the discovery of potential drug candidates. From this perspective, the different chemical compositions of white ginseng and red ginseng could very likely result in different interactions with signaling pathways of diverse biological responses. This paper provides an overview of white ginseng and red ginseng, mainly focusing on their chemical profile and immunomodulation activities. Synergistic effects of ginseng herbal drugs with combinations of other traditional herbal drugs or with synthetic drugs were reviewed. The use of the zebrafish model for bioactivity testing greatly improves the prospects for future ginseng research.

show abstract

“…Aconite Lateralis Radix Praeparata (Fuzi) and Pinelliae Rhizoma (Banxia) are representative of incompatible pairs recorded in “the eighteen antagonisms”, a special rule for TCM incompatibility in formulas, which suggests strictly compatibility prohibition in clinical prescriptions because mutual antagonism results in an undesirable consequence [ 3 , 5 ]. However, coadministration of the two herbs has been used in many clinical formulas for several centuries.…”

Section: Introductionmentioning

confidence: 99%

Fuzi and Banxia Combination, Eighteen Antagonisms in Chinese Medicine, Aggravates Adriamycin‐Induced Cardiomyopathy Associated with PKA/β2AR‐Gs Signaling

Sun

Huang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Aconite Lateralis Radix Praeparata (Fuzi) and Pinelliae Rhizoma (Banxia) are a combination often used to treat cardiovascular diseases in ancient and modern clinical practice. However, eighteen antagonisms based on traditional Chinese medicine (TCM) theory often abided against such combination therapy. Therefore, exploring whether coadministration of the two herbs can be used in adriamycin- (ADR-) induced cardiomyopathy and clarifying the potential mechanism could help to guide its clinical application. Echocardiography experiments revealed that either Fuzi, Banxia, or their combination had effect on ADR-induced heart dysfunction, while high dose Fuzi exerted positive inotropic effect associated with restored PKA levels. Moreover, low dose Fuzi significantly reduced QT/QTc prolongation, inhibited cardiac apoptosis, and upregulated protein expression of PKA. However, combination of Fuzi and Banxia greatly aggravated QT/QTc prolongation and cardiomyocyte apoptosis in ADR rats compared with each drug alone, which was accompanied by a marked decrease in PKA, pSer346 levels. Similarly, Banxia alone treatment promoted cardiac apoptosis and downregulated protein levels of PKA and pSer346. Additionally, high dose Fuzi treatment also produced proapoptotic effect. Taken together, our study has provided the first direct evidence that combination of Fuzi, a positive inotropic agent, with Banxia promoted cardiac apoptosis in an ADR induced rat model of cardiomyopathy, which may be associated with suppression of PKA/β2AR-Gs signaling. This study also provides scientific language for better understanding of the risks and limitations of combination of Fuzi and Banxia in clinical applications.

show abstract

Effect of the Interaction of Veratrum Nigrum with Panax Ginseng on Estrogenic Activity In Vivo and In Vitro

Cited by 21 publications

References 21 publications

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

The Difference between White and Red Ginseng: Variations in Ginsenosides and Immunomodulation

Fuzi and Banxia Combination, Eighteen Antagonisms in Chinese Medicine, Aggravates Adriamycin‐Induced Cardiomyopathy Associated with PKA/β2AR‐Gs Signaling

Contact Info

Product

Resources

About