Effect of the <b><i>FTO</i></b> rs9930506 Polymorphism on the Main Comorbidities of the Cardiorenal Metabolic Syndrome in an Elderly Spanish Cohort

Abstract

Background/Aim: Fat mass and obesity-associated (FTO) gene polymorphisms have been linked to the risk of obesity and diabetes, two well-recognized risk factors for renal disease. Our aim was to determine whether a common FTO polymorphism was associated with a reduced estimated glomerular filtration rate (eGFR) independently of body mass index (BMI) and type 2 diabetes mellitus (T2DM) in a cohort of elderly individuals from the region of Asturias (Northern Spain; RENASTUR cohort). Methods: A total of 544 Spanish Caucasians aged 55-85 years were genotyped for the FTO rs9930506 single-nucleotide polymorphism (SNP). Individuals with a previous diagnosis of renal disease were not eligible for the study. The eGFR was calculated with the Modification of Diet in Renal Disease formula, and individuals with an eGFR of <60 ml/min/1.73 m² (n = 91) were considered as having impaired renal function. The effect of alleles and genotypes on BMI, hypertension, diabetes, eGFR and blood lipid values was statistically determined. Results: The rs9930506 GG genotype was significantly more common in the group with a BMI of >25 (p = 0.03; odds ratio = 2.43; 95% CI: 1.09-5.43). Age and T2DM were significant risk factors for a reduced eGFR, but neither obesity nor the FTO genotypes were associated with a reduced eGFR. Conclusion: The common FTO rs9930506 polymorphism was a risk factor for overweight and obesity in the RENASTUR cohort. However, this SNP was not associated with other comorbidities of the cardiorenal metabolic syndrome in this population.

Adolescent obesity and the role of the fat mass and obesity-associated gene polymorphism

“…Consistent with the literature, we found that the eGFR value was higher in patients with MetS, but there was no significant difference between genotypes/alleles frequencies of the FTO gene. Coto et al did not find any relationship between FTO gene rs9930506 polymorphism and reduced eGFR in the elderly patients with MetS [14]. It has been reported a significant association between FTO gene (rs17817449, rs708259 polymorphisms) and chronic kidney disease [12,13].…”

“…Increased estimated glomerular filtration rate (eGFR) (glomerular hyperfiltration) is one of the early signs of renal complications [10,11]. Based on our current information, there are limited data about the association of rs9939609 variant in FTO gene and hyperfiltration in obese adolescents [12][13][14].…”

A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents

“…In addition, both SNPs were correlated with the early onset of childhood obesity [ 15 ]. In another study by Coto et al carried out among an elderly Caucasian–Spanish population, the frequency of the GG genotype of the rs9930506 polymorphism in people with a BMI higher than 25 was significantly higher than other subjects [ 22 ]. However, some studies have reported contradictory results.…”

Next generation sequencing search for uromodulin gene variants related with impaired renal function

“…All them were Caucasian, aged 56-85 years (45 % male), and from the region of Asturias (Northern Spain, total population one million), and were recruited through the Primary Health Care Center of the city of Oviedo to evaluate the renal function in healthy elderly people [16,17]. Individuals with a history of chronic renal disease or who had suffered cardiovascular disease episodes were not eligible for the study.…”