Effect of the magnetized water supplementation on blood glucose, lymphocyte DNA damage, antioxidant status, and lipid profiles in STZ-induced rats

Abstract

This study investigated the effects of magnetized water supplementation on blood glucose, DNA damage, antioxidant status, and lipid profiles in streptozotocin (STZ)-induced diabetic rats. There were three groups of 4-week-old male Sprague-Dawley rats used in the study: control group (normal control group without diabetes); diabetes group (STZ-induced diabetes control); and magnetized water group (magnetized water supplemented after the induction of diabetes using STZ). Before initiating the study, diabetes was confirmed by measuring fasting blood glucose (FBS > 200 dl), and the magnetized water group received magnetized water for 8 weeks instead of general water. After 8 weeks, rats were sacrificed to measure the fasting blood glucose, insulin concentration, glycated hemoglobin level, degree of DNA damage, antioxidant status, and lipid profiles. From the fourth week of magnetized water supplementation, blood glucose was decreased in the magnetized water group compared to the diabetes group, and such effect continued to the 8th week. The glycated hemoglobin content in the blood was increased in the diabetes group compared to the control group, but decreased significantly in the magnetized water group. However, decreased plasma insulin level due to induced diabetes was not increased by magnetized water supplementation. Increased blood and liver DNA damages in diabetes rats did significantly decrease after the administration of magnetized water. In addition, antioxidant enzyme activities and plasma lipid profiles were not different among the three groups. In conclusion, the supplementation of magnetized water not only decreased the blood glucose and glycated hemoglobin levels but also reduced blood and liver DNA damages in STZ-induced diabetic rats. From the above results, it is suggested that the long-term intake of the magnetized water over 8 weeks may be beneficial in both prevention and treatment of complications in diabetic patients.

Antioxidative effects of magnetized extender containing bovine serum albumin on sperm oxidative stress during long-term liquid preservation of boar semen

“…From a biological aspect, magnetized water has numerous applications. Supplementation with magnetized water has an anti-aging effect [44] and improves blood glucose and lymphocytes [45] in mice. In addition, growth is enhanced by magnetized water in plants [46].…”

Biological Effects of Magnetic Water on Human and Animals

“…Magnetic water may prevent aging and fatigue by increasing the cell membrane permeability [16]. Effectiveness of magnetized water in the prevention and treatment of atherosclerosis has been shown in some animal and human studies [16][17][18][19]. It has been reported that magnetic water help unclog the arteries and veins of deposits of cholesterol and salts and normalize the circulatory system.…”

Investigation of role magnetized water used in supplementary feeding for honeybees to modulate the genotoxic side effects induced by cyclophosphamide in mice bone marrow cells

“…47 Previous studies with magnetized water, reported that the long-term intake of magnetized water (over 8 weeks) may be beneficial in both prevention and treatment of complications in diabetic, treatment effect of magnetized water not only decreased the blood glucose and glycated hemoglobin levels but also reduced blood and liver DNA damages in STZ-induced diabetic rats. 20 Ma et al 48 presented the possibility that magnetic water can prevent aging and fatigue by increasing the cell membrane permeability. Also, the other study showed that administration of magnetized water for at least 6 weeks suppressed the lymphocyte DNA damages in animals with DEN)-induced cancer.…”

“…15,19 Also, it has been demonstrated that intake of magnetized water will result in reduced DNA damage in STZ-induced diabetic rats. 20 The other study showed that administration of magnetized water for at least 6 weeks suppressed the lymphocyte DNA damages in animals with diethyl nitrosamine (DEN)-induced cancer. …”