Effect of the Meibomian Gland Squeezer for Treatment of Meibomian Gland Dysfunction

Wang, Dahu; Liu, Xinquan; Xiao-jun, Hao; Zhang, Yinjian; Zhu, Huang; Dong, Zhi-Guo

doi:10.1097/ico.0000000000001682

Cited by 24 publications

(40 citation statements)

References 51 publications

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“…By contrast, our treatment procedure was standardized and performed by the doctor. Compared with other in-door treatment methods (Zhao et al, 2016;Syed and Sutula, 2017;Wang et al, 2018;Aketa et al, 2019), the device we used has the advantages of being less invasive, lower cost, and more convenient. It is easily managed because of its electric characteristic.…”

Section: Discussionmentioning

confidence: 99%

Eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye: a preliminary investigation

Xie

Jiang

Xia

et al. 2019

J. Zhejiang Univ. Sci. B

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Objective: To evaluate the safety and effectiveness of eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye. Methods: This was a prospective, randomized, open-label, investigator-masked, and self-controlled study. We randomly assigned one eye of patients with meibomian gland dysfunction-associated dry eye to the treatment group, and the other eye to the control group. Both groups received artificial tears and lid warming; the treatment group received an additional one-time in-office eyelid margin cleaning using Deep Cleaning Device. Non-invasive tear break-up time (NITBUT) and tear meniscus height (TMH) of each eye, and Standard Patient Evaluation for Eye Dryness II (SPEED II) score of each patient were evaluated before and at one week after treatment. Results: Thirty eyes of 15 patients were enrolled. No adverse effects occurred during the treatment. Compared with the baseline values, the SPEED score decreased significantly at one week after treatment (mean±95% confidence interval, 11.00±0.99 vs. 5.67±1.67, P<0.0001), the NITBUT-first in the treatment group increased significantly at one week after treatment ((4.74±1.27) s vs. (7.49±2.22) s, P=0.01). The NITBUT-first was significantly longer in the treatment group ((7.49±2.22) s) than in the control group ((5.17±0.91) s) at one week after treatment (P=0.042). No significant differences were found in other tear film parameters between the two groups. Conclusions: Eyelid margin cleaning using the novel Deep Cleaning Device is a convenient, effective, and safe treatment for patients with meibomian gland dysfunction-associated dry eye.

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Section: Discussionmentioning

confidence: 99%

Eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye: a preliminary investigation

Xie

Jiang

Xia

et al. 2019

J. Zhejiang Univ. Sci. B

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“…50 However, in spite of the pain, several studies have demonstrated the efficacy of manual meibomian gland expression for the treatment of MGD. [51][52][53] It is recommended that the procedure be performed once a month until the gland dysfunction is resolved. 2 Although expression of meibomian glands appears to be safe and effective, its evaluation by observer-masked, randomised, controlled trials is necessary, as is the development of new technologies that can achieve such expression with reduced pain.…”

Section: Manual Expression Of Meibomian Glandsmentioning

confidence: 99%

“…2011 The amount of force required to express obstructed glands can be substantial and is usually limited by the associated pain 2011. However, in spite of the pain, several studies have demonstrated the efficacy of manual meibomian gland expression for the treatment of MGD 2018. It is recommended that the procedure be performed once a month until the gland dysfunction is resolved 2011.…”

Section: Treatment Modalitiesmentioning

confidence: 99%

Non‐pharmaceutical treatment options for meibomian gland dysfunction

Arita

Fukuoka

2020

Clinical and Experimental Optometry

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This review examines currently available non-pharmaceutical treatment modalities for meibomian gland dysfunction. A detailed search of the PubMed and MEDLINE databases was performed to identify original articles in English that have evaluated such nonpharmaceutical therapies in patients with this condition. Conventional therapies such as application of a warming compress, the practice of lid hygiene, and manual expression of meibomian glands as well as more technologically advanced approaches such as intraductal probing, thermal pulsation, and intense pulsed light therapy are included in the review. These non-pharmaceutical treatment options may each have a role to play in the management of meibomian gland dysfunction, but more studies are necessary to compare treatments directly under identical experimental conditions in order to determine their relative efficacy. Additional large-scale, randomised, controlled trials are also required to provide more information such as the specific indications best suited to each treatment modality, the efficacy of such approaches in combination with pharmaceutical-based therapy, and the mechanisms of action of some of the more technologically advanced systems.

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“…Recently, many kinds of treatments for DED have been proposed, such as Meibomian gland squeezer, polyunsaturated fatty acids, omega-3 fatty acids, perfluorohexyloctane, chitosan-N-acetylcysteine (C-NAC) and retinol palmitate [186][187][188][189][190][191]. In terms of omega fatty acids, studies demonstrated that ω-3 and ω-6 fatty acids can act directly on human Meibomian gland epithelial cells to influence the quality and quantity of intracellular lipids [192].…”

Section: Other Potential Agentsmentioning

confidence: 99%

Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits

Kuo

Lin

Chien

et al. 2019

JCM

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Dry eye disease (DED) has become common on a global scale in recent years. There is a wide prevalence of DED in different countries based on various ethnicities and environment. DED is a multifactorial ocular disorder. In addition to advanced age and gender, such factors as living at high altitude, smoking, pterygium, prolonged use of consumer electronics or overingesting of caffeine or multivitamins are considered to be the major risk factors of DED. We report the DED epidemiology in Taiwan firstly in this article. According to the pathophysiological factors and changes inthe composition of the tear film in DED, it can be categorized into several subtypes, including lipid anomaly dry eye, aqueous tear deficiency, allergic and toxic dry eye among others. Each subtype has its own cause and disease management; therefore, it is important for ophthalmologists to identify the type through literature review and investigation. The management of DED, relies not only on traditional medications such as artificial tears, gels and ointments, but also newer treatment options such as acupuncture, SYL1001, and nanomedicine therapy. We also conducted a comprehensive literature review including common subtypes and treatment of DED. Clearly, more clinical trials are needed to assess the efficacy and safety of the various treatments and common subtypes of DED.

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Effect of the Meibomian Gland Squeezer for Treatment of Meibomian Gland Dysfunction

Abstract: The meibomian gland squeezer may be safe, effective, and helpful for treatment of MGD and may offer an attractive treatment option for some patients with MGD, although it can cause mild pain or discomfort.

Cited by 24 publications

References 51 publications

Eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye: a preliminary investigation

Eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye: a preliminary investigation

Non‐pharmaceutical treatment options for meibomian gland dysfunction

Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits

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