Effect of the mode of assisted reproductive technology conception on obstetric outcomes for survivors of the vanishing twin syndrome

Sala, Giovanni Battista La; Villani, Maria Teresa; Nicoli, Alessia; Gallinelli, Andrea; Nucera, Giuseppe; Blickstein, Isaac

doi:10.1016/j.fertnstert.2005.11.073

Cited by 54 publications

(69 citation statements)

References 7 publications

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“…The frequency of diagnosis of VT has increased as twin pregnancies have risen in number following the use of ART and as the diagnostic tool, namely the transvaginal ultrasound, has been improved. The prevalence of VT has been reported at 4%-30% after ART, and the impact on obstetric and neonatal outcome has been discussed [1][2][3][4][5][6][7]. Almog et al [1] compared 57 VT deliveries with 171 matched singleton deliveries after ART and observed lower birth weight, an increased rate of low birth weight <2500 g and an increased rate of delivery at <28 weeks of gestation in the VT group.…”

Section: Discussionmentioning

confidence: 99%

“…Almog et al [1] compared 57 VT deliveries with 171 matched singleton deliveries after ART and observed lower birth weight, an increased rate of low birth weight <2500 g and an increased rate of delivery at <28 weeks of gestation in the VT group. Shebl et al [2] compared 46 VT deliveries with 92 matched singletons after ART and showed that VT was associated with small size for gestational age and an increased rate of low birth weight <2500 g. The reasons for these poor VT outcomes are considered to be the direct impact of embryonic loss on the surviving twin, infection and the disturbed placental circulation of blood shunting through inter-twin vascular anastomoses, particularly in monochromatic twins [1,2,6].…”

Section: Discussionmentioning

confidence: 99%

“…La-Sala et al [6] compared 84 VT births with 602 singleton births after IVF/ICSI and showed that the two groups had similar mean gestational age and birth weights as well as similar frequencies of preterm and extremely preterm (≤ 32 weeks gestation) birth, low birth weight, and very low birth weight. Mansour et al [7] reviewed 206 VT and 1891 singleton pregnancies after ICSI and observed that there was no statistically significant difference in the mean gestational age at delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies state that VT is associated with lower birth weight and a high-rate of preterm deliveries [1][2][3][4][5] and that significant similarity are present between the obstetric outcome of VT and twin pregnancies. However, other studies have shown that there is no difference between the obstetric outcome of VT and singletons [6,7]. Despite the high incidence of VT, there has been little research on this topic.…”

Section: Introductionmentioning

confidence: 98%

“…The prevalence of this syndrome is reported in 4%-30% of all singleton deliveries after the use of assisted reproductive technologies (ART) [1][2][3][4][5][6][7]. The impact of VT on obstetric outcome till date has been unknown.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Does a Vanishing Twin Affect Perinatal Outcome?

Akamine¹,

Mekaru²,

Heshiki³

et al. 2017

J Preg Child Health

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Does a Vanishing Twin Affect Perinatal Outcome?

Akamine¹,

Mekaru²,

Heshiki³

et al. 2017

J Preg Child Health

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The mystery of monozygotic twinning II: What can monozygotic twinning tell us about Amyoplasia from a review of the various mechanisms and types of monozygotic twinning?

Hall

2021

American J of Med Genetics Pt A

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Monozygotic (MZ) twins (“identical twins”) are essentially unique to human beings. Why and how they arise is not known. This article reviews the possible different types of MZ twinning recognized in the previous article on twins and arthrogryposis. There appear to be at least three subgroups of MZ twinning: spontaneous, familial, and those related to artificial reproductive technologies. Each is likely to have different etiologies and different secondary findings. Spontaneous MZ twinning may relate to “overripe ova.” Amyoplasia, a specific nongenetic form of arthrogryposis, appears to occur in spontaneous MZ twinning and may be related to twin–twin transfusion.

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Should vanishing twin pregnancies be systematically excluded from cell‐free fetal DNA testing?

et al. 2020

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Objective To demonstrate the feasibility of cell‐free DNA (cfDNA) testing in vanishing twin (VT) pregnancies in routine clinical practice. Methods Our study included 24 874 singleton and 206 VT consecutive pregnancies. Cell‐free DNA was analyzed by massively parallel sequencing. Both aneuploidy analysis (chromosomes 13,18, 21, X, and Y) and fetal fraction estimation were performed according to an Illumina algorithm. Contaminant DNA contribution from the demised co‐twin was studied in detail. Results VT pregnancies exhibited a higher prevalence of screen‐positive cases (5.8% vs 2.5%), sex discrepancies (10.2% vs 0.05%), and false positive rates (FPR) (2.6% vs 0.3%) than singleton pregnancies. However, their incidence was significantly lower in tests performed after the 14th week (screen‐positive cases: 3.1%; sex discrepancies: 7.8%; and FPR: 0.8%). Among the 12 cases in which cfDNA was performed at two time points, fading of contaminating cfDNA was observed in four cases with a sex discrepancy and in one false positive for trisomy 18, resulting in a final correct result. Conclusions Our data suggest VT pregnancies could be included in cfDNA testing as long as it is applied after the 14th week of pregnancy. However, future studies to validate our findings are needed before including VT cases in routine clinical practice. Once established, unnecessary invasive procedures could be avoided, mitigating negative emotional impact on future mothers.

show abstract

Effect of the mode of assisted reproductive technology conception on obstetric outcomes for survivors of the vanishing twin syndrome

Cited by 54 publications

References 7 publications

Does a Vanishing Twin Affect Perinatal Outcome?

Does a Vanishing Twin Affect Perinatal Outcome?

The mystery of monozygotic twinning II: What can monozygotic twinning tell us about Amyoplasia from a review of the various mechanisms and types of monozygotic twinning?

Should vanishing twin pregnancies be systematically excluded from cell‐free fetal DNA testing?

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