Effect of the molecular architecture on the thermosensitive properties of chitosan-g-poly(N-vinylcaprolactam)

Fernández‐Quiroz, Daniel; González-Gómez, Álvaro; Lizardi‐Mendoza, Jaime; Vázquez, Blanca; Goycoolea, Francisco M.; Román, Julio San; Argüelles‐Monal, Waldo

doi:10.1016/j.carbpol.2015.07.069

Cited by 50 publications

(48 citation statements)

References 33 publications

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“…The formation of amide bonds between PVCL-COOH and chitosan amino groups has been confirmed by FTIR [78,80,85], 1 H-NMR [78,85] and Raman [85] spectroscopy techniques. EDC/NHS system is the activator agent usually used by many authors.…”

Section: Synthesismentioning

confidence: 87%

“…After this pioneering work, the synthesis of the chitosan-graft-PVCL by the grafting onto approach has been documented by other authors [79][80][81][82][83][84][85]. The formation of amide bonds between PVCL-COOH and chitosan amino groups has been confirmed by FTIR [78,80,85], 1 H-NMR [78,85] and Raman [85] spectroscopy techniques.…”

Section: Synthesismentioning

confidence: 89%

“…The phase transition behaviour of Cs-g-PVCL in aqueous solutions has been investigated by turbidimetry [78][79][80]85], DSC [79,85] and DLS [96]. The LCST of this copolymer has been estimated between 32 and 42 °C, and it was close to the transition of the corresponding homopolymers.…”

Section: Propertiesmentioning

confidence: 98%

“…In this sense, our group has reported the synthesis of PVCL-COOH samples with different molecular weights by means of controlled radical polymerization and their subsequent grafting onto the chitosan backbone using DMTMM as activator agent. This approach allows a control of the chain length of the grafted PVCL chains, as well as the spacing between grafted side chains onto the chitosan backbone [85].…”

Section: Synthesismentioning

confidence: 99%

“…These parameters have been evaluated by 1 H-NMR [78], thermogravimetric analysis (TGA) [85] and gravimetrically [79,85,90].…”

Section: Propertiesmentioning

confidence: 99%

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Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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Section: Synthesismentioning

confidence: 87%

Section: Synthesismentioning

confidence: 89%

Section: Propertiesmentioning

confidence: 98%

Section: Synthesismentioning

confidence: 99%

“…These parameters have been evaluated by 1 H-NMR [78], thermogravimetric analysis (TGA) [85] and gravimetrically [79,85,90].…”

Section: Propertiesmentioning

confidence: 99%

See 3 more Smart Citations

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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View full text Add to dashboard Cite

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Polyelectrolyte–Ion Complexes as Stimuli‐Responsive Systems for Controlled Drug Delivery

Herrera

Agazzi

Cortez

et al. 2023

Supramolecular Nanotechnology

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Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

Fernández‐Quiroz

Loya‐Duarte

Silva‐Campa

et al. 2019

J of Applied Polymer Sci

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This work describes the preparation of thermosensitive chitosan‐graft‐poly(N‐vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N‐vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug‐association parameters, and the drug‐loaded nanoparticles exhibited dose‐dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti‐cancer drug delivery system. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47831.

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Effect of the molecular architecture on the thermosensitive properties of chitosan-g-poly(N-vinylcaprolactam)

Cited by 50 publications

References 33 publications

Chitosan-Based Thermosensitive Materials

Chitosan-Based Thermosensitive Materials

Polyelectrolyte–Ion Complexes as Stimuli‐Responsive Systems for Controlled Drug Delivery

Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

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