It is important to solve the partial fatigue wear of large forging dies, where the service life can be short. The purpose of this paper is to use laser remelting biomimetic technology to prepare a coupling biomimetic model combination on the mold surface, strengthen the local fatigue wear resistance of the mold, and extend the service life of the mold. Three types of laser energies were used to prepare the coupling biomimetic elements and analyze the microstructure and phase composition of the specific gravity melting zone. The biomimetic units were combined into a variety of coupling biomimetic models (fringe, mesh, and dense array models with different laser energies), and the number of fatigue cracks and the weight of wear loss of the coupling biomimetic model were compared at different temperatures. The mechanism of the coupling bionic model was analyzed, and the coupling bionic surface with a dense row structure was determined to have strong anti-fatigue wear performance. According to the Range Method, the relationship between wear and fatigue temperature and laser energy of the coupled bionic model was determined. Using DEFORM software to simulate the stress, temperature, and wear conditions of the front axle die surface, different coupling biomimetic model combinations were prepared on the abrasive surface. The die wear and cut edge width of the forgings were reduced after practical production, which proved that the laser bionic local strengthening method can effectively prolong the service life of a die.