Effect of the rapid‐acting insulin analogue insulin aspart on quality of life and treatment satisfaction in patients with Type 1 diabetes

Abstract

Under these study conditions, IAsp improved treatment satisfaction and quality of life regarding diet restrictions when compared with human insulin. The 'numbers needed to treat' for important quality of life benefits indicate that the effect of IAsp in this regard is not trivial.

Treatment Satisfaction and Quality of Life With Insulin Glargine Plus Insulin Lispro Compared With NPH Insulin Plus Unmodified Human Insulin in Individuals With Type 1 Diabetes

“…In the current study, however, the between-group difference in the DTSQs treatment satisfaction score was much greater, at 8.6. The between-group differences in each of the items of the DTSQs in the current study were also much greater than those reported in previous studies comparing insulin glargine with NPH insulin or rapidacting insulin analogs with unmodified human insulin (4,13,22). This result suggests that the combination of insulin glargine and a rapid-acting insulin analog might have a synergistic benefit on treatment satisfaction.…”

“…Rapid-acting insulin analogs have been shown to improve treatment satisfaction compared with unmodified human insulin in individuals with type 1 diabetes, with reported between-group differences in the DTSQs treatment satisfaction score of 1.6 -2.3 (11)(12)(13)(14). Similar studies have reported improvements in the DTSQs treatment satisfaction score with insulin glargine compared with NPH insulin of 0.9 -1.8 (4,21).…”

“…It was previously shown, in the same study participants as those involved in the present report, that insulin glargine in combination with insulin lispro improves overall glycemic control, as assessed by A1C and 24-h plasma glucose monitoring, to a clinically significant degree, together with a reduction in nocturnal hypoglycemia (8). Although psychological outcomes have been evaluated in studies comparing insulin glargine with NPH insulin (4) and rapid-acting insulin analogs with unmodified human insulin (11)(12)(13)(14), there are no comprehensive reports of psychological outcomes comparing a combined rapid-acting and long-acting analog regimen with NPH insulin plus unmodified human insulin.…”

Instrumentos de avaliação de qualidade de vida relacionada à saúde no diabetes melito

“…O uso da insulinoterapia em algumas pesquisas está associado a valores baixos de QV (20,21); em outras pesquisas, o uso da insulina pode melhorar a QV (22)(23)(24), ou até mesmo não influenciá-la (25). A avaliação de QV em pacientes diabéticos é bem mais complexa e inter-relacionada e a insulinoterapia pode levar ao melhor controle glicêmico, mas também pode aumentar o risco de hipoglicemia em pacientes com DM.…”

Narrative Review: A Rational Approach to Starting Insulin Therapy

“…The availability of insulin analogues enhances flexibility and convenience for insulin-treated patients, and this increased flexibility in insulin timing is associated with an improvement in quality-of-life measures (25). The increasing variety of insulin preparations allows more opportunities to achieve control.…”