Effect of the rs10767664 Variant of the Brain-Derived Neurotrophic Factor Gene on Weight Change and Cardiovascular Risk Factors in Morbidly Obese Patients after Biliopancreatic Diversion Surgery

Abstract

Background: The effect of the rs10767664 variant of the brain-derived neurotrophic factor gene on weight loss after bariatric surgery has not been evaluated. We decided to investigate the role of the rs10767664 variant on outcomes after biliopancreatic diversion surgery. Materials and Methods: A sample of 90 patients with morbid obesity without diabetes mellitus was operated. Biochemical and anthropometric evaluation were realized at basal visit and at each visit during 3 years (at 1, 2 and 3 years). Results: Initial percentage excess weight loss, body mass index, weight, waist circumference, fat mass, blood pressure, low-density lipoprotein cholesterol, total cholesterol, triglyceride levels, insulin and homeostasis model assessment for insulin resistance (HOMA-IR) improved. No differences in these changes were detected between the two genotypes (wild-type group AA vs. mutant group AT plus TT) in a dominant model. The improvement of insulin levels was lower in T-allele carriers than non-T-allele carriers (-2.8 ± 0.7 vs. -7.1 ± 0.9 UI/dl; p = 0.02). The decrease of fasting glucose (-13.4 ± 7.4 vs. -24.2 ± 5.2 mg/dl; p = 0.01) and HOMA-IR (-1.1 ± 0.3 vs. -0.5 ± 0.4 units; p = 0.02) were lower in T-allele carriers than non-T-allele carriers. Conclusion: Our data showed an association between the rs10767664 variant and metabolic response after weight loss. Non-T-allele carriers have a better improvement in glucose, insulin and HOMA-IR levels than T-allele carriers.

Cardiovascular Risk Factors and Insulin Resistance after Two Hypocaloric Diets with Different Fat Distribution in Obese Subjects: Effect of the rs10767664 Gene Variant in Brain-Derived Neurotrophic Factor

“…However, there is a lack of information about the influence of weight loss on this association in intervention studies. Only one study after weight loss intervention (bariatric surgery) has been performed, with the most prevalent SNP of the BDNF gene (rs10767664) [17]. In that study the rs10767664 variant of the BDNF gene did not influence weight loss or lipid profile.…”

“…To the best of our knowledge, this is the first dietary intervention randomized clinical trial where a different effect of a hypocaloric MUFAs-enriched diet was obtained. The influence of rs10767664 variant of the BDNF gene on the response of insulin and HOMA-IR after weight loss has not been described in the literature; only the effect of a huge weight loss (42 kg during 3 years of follow-up) after biliopancreatic diversion [17] has previously been described. The physiological mechanisms implied in this association of glucose metabolism and BDNF gene variants remain unknown.…”

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

“…Follow‐up ranged from 6 months to 7 years. Weight loss was expressed as change in BMI in 11 studies, 25–34 percentage excess BMI loss (EBMIL) in one study, 35 percentage TWL in nine studies, 36–44 and excess weight loss (EWL) in 29 studies 45–73 . Patients underwent various types of bariatric procedures including RYGB, SG, and LAGB.…”

“…Follow‐up ranged from 6 months to 5 years. Changes in frequency of obesity‐related metabolic problems were reported in 18 studies, 32,40,47–60,68,72 and fasting glucose, HOMA IR, HbA1c, and/or lipids were reported in 21 studies 27,29,47–60,68,69,74–76 . One study used diabetes remission, defined as cessation of antidiabetic therapies, as outcome 34 .…”

Bariatric Surgery and Precision Nutrition

“…This indicates that not only the environment but also genetic variations account for successful weight-loss therapy [ 20 , 21 ]. Several genes as well as single nucleotide polymorphisms (SNPs) are associated with obesity phenotypes and weight loss after bariatric surgery [ 21 , 22 , 23 , 24 , 25 ].…”