Abstract.To enhance the compatibility between heat exchanger used in automobile exhaust thermoelectric generator (AETEG) and internal combustion engine, three different kinds of layouts among heat exchanger, muffle and catalytic converter are designed, and the effects on the temperature uniformity and temperature distribution of heat exchanger, the back pressure of engine are also analyzed respectively. The simulated results reveal that the sequential layout of three-way catalytic converter-heat exchanger-automotive exhaust muffle is the best choice, for it ensures the smallest back drops of engine, considerable temperature uniformity and relatively higher temperature distribution of heat exchanger on the same occasion, which improves the performance degradation of engine during the exhaust thermoelectric generation and provides guiding reference for the optimization of AETEG.