Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

Salatin, Sara; Dizaj, Solmaz Maleki; Khosroushahi, Ahmad Yari

doi:10.1002/cbin.10459

Cited by 497 publications

(292 citation statements)

References 95 publications

(113 reference statements)

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“…In particular, surface modification can alter the extent and rate of cell entrance of NPs. For example, positive charges on the NPs increase electrostatic interaction with the negatively-charged membrane, thereby promoting cellular uptake (Salatin et al, 2015). In some instances, surface modification of NPs affects not only intracellular uptake, but also subcellular distribution inside the cell.…”

Section: Discussionmentioning

confidence: 99%

Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products

et al. 2016

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-It has been recognized that the use of nanoparticles (NPs) in the cosmetic industry results in products with better efficacy and functionality. However, recent advances in molecular toxicology have revealed that NP exposure can promote cytotoxicity and oxidative damage, which has raised health concerns in the use of NPs in personal care products. Nevertheless, the mechanistic basis for the toxicity and safety of cosmetic NPs is poorly understood. The goal of the study was to determine the cytotoxicity and intracellular distribution of titanium dioxide (TiO 2 ) NPs containing fatty acid composites (palmitoleic acid, palmitic acid, stearic acid and oleic acid) commonly used in cosmetic products. Two types of cells, human fibroblast skin cells and adenocarcinoma lung cells, were exposed to either bare TiO 2 NPs or TiO 2 NPs mixed with fatty acids for up to 48 hr. NMR analysis confirmed that the fatty acid composites remained in the NPs after wash. The cytotoxicity of TiO 2 NPs was determined by cell viability measurement using quantitative confocal microscopy, and the localization of two different forms of TiO 2 NPs were assessed using electron spectroscopic imaging with transmission electron microscopy. TiO 2 NPs containing fatty acids posed significantly reduced cytotoxicity (80-88% decreases) than bare NPs in both cell types. Furthermore, there was less intracellular penetration of the NPs containing fatty acid composites compared with bare NPs. These results provide important insights into the role of fatty acids in protecting the cells from possible toxicity caused by NPs used in the production of cosmetic products.

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Section: Discussionmentioning

confidence: 99%

Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products

et al. 2016

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“…Another important factor influencing the rate of absorption and uptake is the NP shape. This is related to the increase of the surface area to volume ratio for cylindrical or rod shapes with a consequent increase of the surface available for absorption to the membrane [24,71]. Moreover, it has been recently observed that the details of the NP surface topology have considerable effect on cellular uptake [21].…”

Section: Nanoparticle-membrane Interactions: Elastic Theorymentioning

confidence: 99%

Nanoparticle–membrane interactions

Contini

Schneemilch

Gaisford

et al. 2017

Journal of Experimental Nanoscience

154

109

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Engineered nanomaterials have a wide range of applications and as a result, are increasingly present in the environment. While they offer new technological opportunities, there is also the potential for adverse impact, in particular through possible toxicity. In this review, we discuss the current state of the art in the experimental characterisation of nanoparticle-membrane interactions relevant to the prediction of toxicity arising from disruption of biological systems. One key point of discussion is the urgent need for more quantitative studies of nano-bio interactions in experimental models of lipid system that mimic in vivo membranes.

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“…Therapeutic agents can be encapsulated within nanoparticles or incorporated via surface adsorption or surface conjugation Salatin et al 2015b). The integration of therapeutic agents into the nanoparticles with desirable shape, size, and surface physicochemical characteristics imposes a significant effect on improving their solubility, circulation half-life, bio-distribution and reducing the immunogenicity (Sun et al 2014, Salatin et al 2015a.…”

Section: Nanoparticles Polymeric Nanoparticlesmentioning

confidence: 99%

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

et al. 2016

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Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intravenous administration. Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations. However, the rapid mucociliary clearance of the drug-loaded nanoparticles can cause a reduction in bioavailability percentage after intranasal administration. Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption. It is most certain that the high viscosity of hydrogel-based nanosystems can efficiently offer this mucoadhesive property. This update review discusses the possible benefits of using hydrogel polymer-based nanoparticles and hydrogel nanocomposites for drug/vaccine delivery through the intranasal administration.

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Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

Cited by 497 publications

References 95 publications

Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products

Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products

Nanoparticle–membrane interactions

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

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