Effect of the topical application of 50% lignocaine hydrochloride on the sensitivity of dentine in man

Rirattanapong, Praphasri; Vongsavan, Kadkao; Kraivaphan, Petcharat; Vongsavan, Noppakun; Matthews, Bruce

doi:10.1016/j.archoralbio.2013.06.003

Cited by 10 publications

(14 citation statements)

References 19 publications

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“…Without iontophoresis, even a 50% solution of lignocaine applied topically produced anaesthesia for a maximum of 10 min, and after a latent period of up to 30 min. 7 The duration of the anaesthesia produced by the iontophoresis of lignocaine with epinephrine appeared to be similar to that of the reduction in blood flow, when the rate of diffusion of the lignocaine towards the pulp would have been enhanced and the rate of its washout by the circulating blood, reduced. Further experiments are required to determine the optimal concentration of epineprine to use.…”

Section: Discussionmentioning

confidence: 88%

“…Amess and Matthews 6 also showed that the application of 50% lignocaine HCl to human dentine for 10 min blocked the pain produced by air blast stimuli. More recently, Rirattanapong et al, 7 demonstrated that 50% lignocaine HCl could anaesthetize dentine to air-blast and probing stimuli but this effect required an application of up to 30 min, which is too long for routine clinical use.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Effects of the iontophoresis of lignocaine with epinephrine into exposed dentine on the sensitivity of the dentine in man

Thongkukiatkun

Vongsavan

Kraivaphan

et al. 2015

Archives of Oral Biology

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 98%

Effects of the iontophoresis of lignocaine with epinephrine into exposed dentine on the sensitivity of the dentine in man

Thongkukiatkun

Vongsavan

Kraivaphan

et al. 2015

Archives of Oral Biology

Self Cite

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“…Only one study had low risk of bias in blinding of outcome assessment and the rest had unclear risks of bias. Overall, the included studies in vitro had unclear risks of random-sequence generation and allocation concealment [24,[28][29][30][31][32][33][34][35].…”

Section: Assessment Of Methodological Qualitymentioning

confidence: 99%

“…There was significant heterogeneity when data from the eight studies reporting surface microhardness were pooled (Chi 2 = 30.14, df = 7, p < 0.0001, I 2 = 77%) [28][29][30][31][32][33][34][35]; therefore, a random-effects model of analysis was used (Fig. 3C).…”

Section: Smh From In Vitro Experimentationmentioning

confidence: 99%

Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: A systematic review and meta-analysis

Lin

Zhong

et al. 2019

Preprint

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Background: This systematic review with meta-analyses sought to answer whether casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) provided a remineralizing benefit superior to that of nonintervention or placebo. Methods: The Cochrane databases, PubMed, EmBase, and Ovid up to May 20th, 2019, were scanned, only published in English. Study information extraction and methodological quality assessments were accomplished independently by two reviewers. The “Criteria for judging risk of bias in the ‘Risk of bias’ assessment tool” was used for methodological quality assessment. The continuous data was analyzed by mean difference (MD) or standardized mean difference (SMD) with a 95% confidence interval (CI). Review Manager 5.3 was used for statistical analysis. Outcome variables include quantitative light-induced fluorescence in clinical research, average surface roughness and surface microhardness in vitro. Results: There were significant differences in the quantitative light-induced fluorescence (SMD = −0.43, 95% CI: [−0.79, −0.07], P = 0.02), average surface roughness (SMD = −8.21, 95% CI: [−10.37, −6.04], P < 0.01), Vickers microhardness (SMD = 1.19, 95% CI: [0.72, 1.66], P < 0.01), and Knoop microhardness (SMD = 3.52, 95% CI: [2.68, 4.36], P < 0.01) between the CPP-ACP and control groups or baseline. Conclusion: Within the limitations of this meta-analysis, CPP-ACP exhibited excellent remineralization effects evaluated in clinical research and in vitro, indicating outstanding restoration of form, aesthetics, and function in treating white spot lesions.

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“…Lid HCl was chosen as a modal substance because of its wide spectrum of application in dentistry and maxillofacial surgery . This anesthetic agent, in addition to its primary function, is a membrane stabilizer and phospholipase A2 inhibitor …”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of polymeric formulations designed for use in alveolar osteitis

Nowak

Szterk

Szymborski

et al. 2015

J of Applied Polymer Sci

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In this article, we present a potential use of biodegradable polymers as a drug‐delivery system designed for alveolar osteitis (AO) management. The release characteristics of lidocaine hydrochloride from alginate or hyaluronate xerogels, which covered the microcrystalline chitosan scaffold, were examined as drug carriers, wound dressings, and potential devices in bone regeneration. The materials were characterized by Fourier transform infrared spectroscopy to confirm that there was no additional covalent bonding between the polymeric membranes and the anesthetic agent. Surface‐eroding matrices (ca. 120 μm) encapsulated the main substance, and the morphologies of all of the structures were measured by scanning electron microscopy. Positive results were obtained, and the data suggested an important impact of materials selection on the physicochemical properties and drug release. Additionally, the mechanical properties, such as the hardness, adhesiveness, springiness, and cohesiveness, of the tested materials were evaluated. A study of the swelling confirmed one of the assumptions that the materials could be used as a potential wound dressing and emphasized the resistance of the materials in the condition imitating the movement of the masticatory system. A cytotoxicity test of the formulations was performed to prove the materials’ nontoxicity. The aim of this study was to design and propose an in vitro evaluation of a new drug formulation as a potential application for the treatment of AO. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 42991.

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Effect of the topical application of 50% lignocaine hydrochloride on the sensitivity of dentine in man

Cited by 10 publications

References 19 publications

Effects of the iontophoresis of lignocaine with epinephrine into exposed dentine on the sensitivity of the dentine in man

Effects of the iontophoresis of lignocaine with epinephrine into exposed dentine on the sensitivity of the dentine in man

Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: A systematic review and meta-analysis

In vitro evaluation of polymeric formulations designed for use in alveolar osteitis

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