This paper introduces a unified multivariate overnight GARCH-Itô model for volatility matrix estimation and prediction both in the low-and high-dimensional set-up. To account for whole-day market dynamics in the financial market, the proposed model has two different instantaneous volatility processes for the open-to-close and close-to-open periods, while each embeds the discrete-time multivariate GARCH model structure. We call it the multivariate overnight GARCH-Itô (MOGI) model. Based on the connection between the discrete-time model structure and the continuous-time diffusion process, we propose a weighted least squares estimation procedure for estimating model parameters with open-to-close high-frequency and close-to-open low-frequency finan-cial data, and establish its asymptotic theorems. We further discuss the prediction of future vast volatility matrices and study its asymptotic properties. A simulation study is conducted to check the finite sample performance of the proposed estimation and prediction methods. The empirical analysis is carried out to compare the performance