Effect of the variation of loading frequency on surface failure of bovine articular cartilage

Sadeghi, Hamid; Shepherd, Duncan E.T.; Espino, Daniel M.

doi:10.1016/j.joca.2015.06.002

Cited by 57 publications

(71 citation statements)

References 53 publications

(74 reference statements)

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“…However, the same peak load and number of cycles at 1 Hz did not create any cracks. This observation is consistent with previous findings that following 10,000 cycles of compressive stress in the range of between ~ 3 and 7.5 MPa, through an indenter, produced surface cracks on cartilage [30]. It should be noted that both this current study and previous study by Sadeghi et al [30] tested cartilage-on-bone.…”

Section: Discussionsupporting

confidence: 93%

“…This observation is consistent with previous findings that following 10,000 cycles of compressive stress in the range of between ~ 3 and 7.5 MPa, through an indenter, produced surface cracks on cartilage [30]. It should be noted that both this current study and previous study by Sadeghi et al [30] tested cartilage-on-bone. The physical behaviour of cartilage when on and off-bone was suggested to be different [39] because of the restraining effects of the underlying bone to cartilage [40, 41].…”

Section: Discussionsupporting

confidence: 93%

“…Testing involved the application of up to 10,000 cycles of sinusoidally varying compressive force at loading frequencies of 1, 10, 50 and 100 Hz [14, 30]. A total of 120 cartilage specimens, obtained from 10 joints, were subjected to the cyclic three-point bend tests.…”

Section: Methodsmentioning

confidence: 99%

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Fatigue strength of bovine articular cartilage-on-bone under three-point bending: the effect of loading frequency

Sadeghi

Espino

Shepherd

2017

BMC Musculoskelet Disord

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BackgroundThe objective of this study was to determine the influence of loading frequency on the failure of articular cartilage-on-bone specimens under three-point bending.MethodsIn this study, cyclic three-point bending was used to introduce failure into cartilage-on-bone specimens at varying loading frequencies. Sinusiodally varying maximum compressive loads in the range 40–130 N were applied to beam-shaped cartilage-on-bone specimens at frequencies of 1, 10, 50 and 100 Hz.ResultsThe number of cycles to failure decreased when loading frequency increased from normal and above gait (1 and 10 Hz) to impulsive loading frequencies (50 and 100 Hz). It was found that 67 and 27% of the specimens reached run-out at loading of 10,000 cycles at frequencies of 1 and 10 Hz, respectively. However, 0% of the specimens reached run-out at loading frequencies of 50 and 100 Hz.ConclusionThe results indicate that increasing the loading frequency reduces the ability of specimens to resist fracture during bending. The findings underline the importance of the loading frequency concerning the failure of articular cartilage-on-bone and it may have implications in the early onset of osteoarthritis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

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Fatigue strength of bovine articular cartilage-on-bone under three-point bending: the effect of loading frequency

Sadeghi

Espino

Shepherd

2017

BMC Musculoskelet Disord

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“…Although this simplified model assumed one directional fluid flow neglecting the flow through the disc lateral surface, the obtained velocity value is comparable to the interstitial fluid velocity of 3.14 × 10 −10 m/s reported for a damaged articular cartilage tissue under a rolling load. 87 This result indicates again relevance of the bioreactor conditions applied.…”

Section: Discussionmentioning

confidence: 77%

Functional bioreactor characterization to assess potentials of nanocomposites based on different alginate types and silver nanoparticles for use as cartilage tissue implants

Zvicer

Mišković‐Stanković

Obradović

2018

J Biomedical Materials Res

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In this work, functional characterization of biomaterials concerning potential application as articular cartilage implants was performed by using a biomimetic bioreactor with dynamic compression in the physiological regime (10% strain, 0.84 Hz frequency, 1 h on/1 h off). Specifically, two alginate types with low (LG) and high (HG) guluronic/mannuronic residue ratios with electrochemically synthesized silver nanoparticles (AgNPs) were evaluated. HG Ag/alginate hydrogels were clearly indicated as potential candidates due to better initial mechanical properties as compared to LG hydrogels (dynamic compression modulus of ~60 vs. ~40 kPa) as well as the mechanical stability displayed during 7 days of dynamic compression. Cytotoxicity studies in 3D bovine cartilage explant cultures under dynamic compression have shown negligible effects as compared to standard 2D monolayers of bovine chondrocytes where moderate cytotoxicity was observed. Finally, experimental and mathematical modeling studies revealed different mechanisms of AgNP release under physiological‐like bioreactor conditions as compared to static conditions. Overall, the results clearly demonstrate bioreactor advantages in characterization and selection of candidate biomaterials as well as potentials to bridge the in vitro‐in vivo gap. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 755–768, 2019.

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“…The first signs of cartilage degeneration are proteoglycan (PG) loss and collagen degeneration, leading to higher permeability of the tissue . The mechanisms driving these changes during the progression of OA are still not fully understood, but it has been suggested that excessive stresses, strains, and cumulative loadings in cartilage play a major role …”

mentioning

confidence: 99%

New algorithm for simulation of proteoglycan loss and collagen degeneration in the knee joint: Data from the osteoarthritis initiative

Mononen

Tanska

Isaksson

et al. 2017

Journal Orthopaedic Research

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Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic. Currently, there is only one modeling framework which can be applied to predict the progression of knee osteoarthritis but it only considers degenerative changes in the collagen fibril network. Here, we have developed the framework further by considering all of the major tissue changes (proteoglycan content, fluid flow, and collagen fibril network) occurring in osteoarthritis. While excessive levels of tissue stresses controlled degeneration of the collagen fibril network, excessive levels of tissue strains controlled the decrease in proteoglycan content and the increase in permeability. We created four knee joint models with increasing degrees of complexity based on the depth-wise composition. Models were tested for normal and abnormal, physiologically relevant, loading conditions in the knee. Finally, the predicted depth-wise compositional changes from each model were compared against experimentally observed compositional changes in vitro. The model incorporating the typical depth-wise composition of cartilage produced the best match with experimental observations. Consistent with earlier in vitro experiments, this model simulated the greatest proteoglycan depletion in the superficial and middle zones, while the collagen fibril degeneration was located mostly in the superficial zone. The presented algorithm can be used for predicting simultaneous collagen degeneration and proteoglycan loss during the development of knee osteoarthritis. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1673-1683, 2018.

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Effect of the variation of loading frequency on surface failure of bovine articular cartilage

Abstract: The increase in crack length with loading frequency indicated that, increased loading frequency can result in cartilage becoming damaged. The results of this study have implications in the early stages of osteoarthritis.

Cited by 57 publications

References 53 publications

Fatigue strength of bovine articular cartilage-on-bone under three-point bending: the effect of loading frequency

Fatigue strength of bovine articular cartilage-on-bone under three-point bending: the effect of loading frequency

Functional bioreactor characterization to assess potentials of nanocomposites based on different alginate types and silver nanoparticles for use as cartilage tissue implants

New algorithm for simulation of proteoglycan loss and collagen degeneration in the knee joint: Data from the osteoarthritis initiative

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