Effect of the Wnt signal-RANKL/OPG axis on the enhanced osteogenic integration of a lithium incorporated surface

Abstract

Bone remolding involves the formation of new bone by osteoblasts and the absorption of old bones by osteoclasts.

The Skeletal-Protecting Action and Mechanisms of Action for Mood-Stabilizing Drug Lithium Chloride: Current Evidence and Future Potential Research Areas

“…The results indicated that the bone with Li-MAO-ETP implants had a higher push-out load, bone ingrowth and bone mineralization than the bone with MAO-ETP implants after 12 weeks of implantation (Liu et al, 2018). Huang et al (2019) implanted lithium-incorporated sandblasted, large-grit, and acidetched (Li-SLA) titanium discs into the trabecular bone of femur condyle in rabbits. In their study, osseointegration and new bone formation were assessed using micro-CT after 2, 4, and 8 weeks of implantation.…”

“…In their study, osseointegration and new bone formation were assessed using micro-CT after 2, 4, and 8 weeks of implantation. More osteoids and new bone were covering the implants and higher BV/TV and BIC were detected in the Li-SLA group (Huang et al, 2019). Using a bigger animal model, Zhang and colleagues assessed the effects of lithium-doped silica nanospheres and poly(dopamine) composite coating on polyetheretherketone (LPPK) implantation on bone integration.…”

Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and SaOS-2 Cells

“…Similarly, in antibacterial screens, collection strains are often used, whose virulence and adherence capability might differ from those found in wild-type strains isolated from implants [28,29]. In addition, the promotion of tissue integration is not often tested on antimicrobial screens, and, if it happens to be included, the testing is done separately from the antibacterial properties [30][31][32][33][34]. This is less than ideal as anti-biofilm/antibacterial capability and tissue integration should be preferably tested together.…”

Kasuistik: Systemische Enthesitis unter Lithiumerhaltungstherapie wegen einer Bipolaren Störung

“…Diese Kaskade stimuliert aber auch die Proliferation der Osteoblasten und deren Produktion von Osteoprotegerin (OPG) mit konsekutiver Erhöhung des OPG/Rankl-Quotienten und einer Verschiebung des Knochenstoffwechsels zugunsten des Knochenanbaus im Verhältnis zur osteoklastären Knochenresorption. Diesen über den WNT/ß-Catenin-Signalweg vermittelten positiven Effekt auf die Knochenbildung durch Lithiumsowohl bei einer systemischen Supplementation als auch bei einer lokalen Applikationwurde experimentell in vivo und in vitro bestätigt [10][11][12]. Zurzeit wird in einer Phase-II-Studie untersucht, ob eine niedrig dosierte orale Lithiumapplikation eine positive Wirkung auf die Knochenfrakturheilung hat [13].…”