Effect of three-drug delivery modalities on olfactory function in chronic sinusitis

Reychler, Grégory; Colbrant, Coralie; Huart, Caroline; Guellec, Sandrine Le; Vecellio, Laurent; Liistro, Giuseppe; Rombaux, Philippe

doi:10.1002/lary.24937

Cited by 31 publications

(29 citation statements)

References 38 publications

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“…2). Four studies in CRS mixed 12,14,16,17 presented TDI total scores, yielding a population of 253 patients. Pooled TDI score was 21.96 6 8.88, which falls into hyposmic range (Table IV).…”

Section: Search Characteristicsmentioning

confidence: 99%

“…SNIFFIN' STICKS-THRESH-OLD. Six studies in CRS mixed 12,14,16,[53][54][55] and two studies in CRSwNP 18,19 presented threshold scores, yielding a population of 386 and 187 patients, respectively. Olfactory dysfunction using the Sniffin' Sticks threshold tests is defined as 6.00 in males and 6.50 in females.…”

Section: -Item Smell Identifi-cation Test Four Studies In Crs Mixedmentioning

confidence: 99%

“…SNIF-FIN' STICKS-DISCRIMINATION. Three studies in CRS mixed 12,14,16 and two studies in CRSwNP 18,19 presented discrimination scores, yielding a population of 189 and 187 patients, respectively. Olfactory dysfunction using the Sniffin' Sticks-Discrimination is defined as 10.…”

Section: -Item Smell Identifi-cation Test Four Studies In Crs Mixedmentioning

confidence: 99%

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The prevalence of olfactory dysfunction in chronic rhinosinusitis

et al. 2016

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Objective Many studies have reported that olfactory dysfunction frequently occurs in chronic rhinosinusitis (CRS) populations; however, the prevalence and degree of olfactory loss has not been systematically studied. The aims of this study are to use combined data to report the prevalence of olfactory dysfunction and to calculate weighted averages of olfactory test scores in CRS patients. Data Sources A search was conducted in PubMed and Scopus, following the methods of Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Review Methods Studies reporting the prevalence of olfactory dysfunction using objective measures or olfactory test scores using validated scales were included. Results A total of 47 articles were included in systematic review and 35 in the pooled data analysis. The prevalence of olfactory dysfunction in chronic rhinosinusitis was found to be 30.0% using the Brief Smell Identification Test, 67.0% using the 40-item Smell Identification Test, and 78.2% using the total Sniffin’ Sticks score. Weighted averages ± standard deviation of olfactory test scores were 25.96±7.11 using the 40-item Smell Identification Test, 8.60±2.81 using the Brief Smell Identification Test, 21.96±8.88 using total Sniffin’ sticks score, 5.65±1.51 using Sniffin’ Sticks threshold, 9.21±4.63 using Sniffin’ Sticks discrimination, 9.47±3.92 using Sniffin’ Sticks Identification, and 8.90±5.14 using the questionnaire for olfactory disorders-negative statements. Conclusion In chronic rhinosinusitis populations, a significant percentage of patients experience olfactory dysfunction and mean olfactory scores are within the dysosmic range.

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“…2). Four studies in CRS mixed 12,14,16,17 presented TDI total scores, yielding a population of 253 patients. Pooled TDI score was 21.96 6 8.88, which falls into hyposmic range (Table IV).…”

Section: Search Characteristicsmentioning

confidence: 99%

Section: -Item Smell Identifi-cation Test Four Studies In Crs Mixedmentioning

confidence: 99%

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The prevalence of olfactory dysfunction in chronic rhinosinusitis

et al. 2016

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“…Interestingly, oral and nebulized corticosteroids yielded equivalent, clinically relevant improvements in objective olfactory measures, which were significantly higher than the standard intranasal formulation. While the latter proved ineffective, the authors noted that the abbreviated duration of therapy (16 days) compared to what is ordinarily employed in clinical practice could have contributed to the absence of effect (Reychler et al, 2015).…”

Section: Medical Therapymentioning

confidence: 99%

Diseases of the nasal cavity

Schwartz

Tajudeen

Kennedy

2019

Handbook of Clinical Neurology

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Despite garnering minimal attention from the medical community overall, olfaction is indisputably critical in the manner in which we as humans interact with our surrounding environment. As the initial anatomical structure in the olfactory pathway, the nasal airway plays a crucial role in the transmission and perception of olfactory stimuli. The goal of this chapter is to provide a comprehensive overview of olfactory disturbances as it pertains to the sinonasal airway. This comprises an in-depth discussion of clinically relevant nasal olfactory anatomy and physiology, classification systems of olfactory disturbance, as well as the various etiologies and pathophysiologic mechanisms giving rise to this important disease entity. A systematic clinical approach to the diagnosis and clinical workup of olfactory disturbances is also provided in addition to an extensive review of the medical and surgical therapeutic modalities currently available.

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“…After duplicates removal, 506 articles were identified and screened. At the end of the process, eight RCT were included in the systematic review (13)(14)(15)(16)(17)(18)(19)(20) . (19) , Total Nasal Symptom Score (15,24) , Lund-Kennedy Score (18) and Sino-Nasal Outcome Test (SNOT-20) (17) .…”

Section: Study Selectionmentioning

confidence: 99%

Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review

Reychler

Domachowski

Latiers

et al. 2018

Rhin

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Background: Treatment of chronic rhinosinusitis (CRS) aims to treat the underlying inflammation or infection. Although the optimal modality of administration remains controversial, inhalation route is usually preferred. The aim of this systematic review was to summarize the efficacy of intranasal corticoisteroids or antibiotics delivery by nebulization on symptoms, histology, endoscopy scores, nasal obstruction, clinical outcomes and quality of life in CRS.Method: This systematic review followed the PRISMA guidelines. Randomized controlled, comparative and cohort studies evaluating effects of treatment by nebulization in sinusitis were identified and reviewed from two databases (PubMed and Scopus). Two reviewers independently assessed study quality and reviewed the selected studies.Results: 600 references were retrieved and 12 studies evaluating 377 patients were included in the systematic review. Different devices were used. Efficacy of nasal delivery by nebulization was systematically observed on symptoms and size of polyps and frequently on inflammatory parameters in all studies. The presence of polyps improved the efficacy of the nebulization. This way of delivery appears not convincing regarding antibiotics. Few side effects were noted in the retrieved studies and only for nebulized antibiotics. Conclusions:This systematic review highlighted that based on the present literature nebulization is not better than nasal spray to the delivery of corticosteroids due to the positive results on symptoms, endoscopic appearance and histological outcomes. For antibiotics delivery, the nebulization is not of added value.

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Effect of three-drug delivery modalities on olfactory function in chronic sinusitis

Cited by 31 publications

References 38 publications

The prevalence of olfactory dysfunction in chronic rhinosinusitis

The prevalence of olfactory dysfunction in chronic rhinosinusitis

Diseases of the nasal cavity

Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review

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