Effect of thyrotropin-releasing hormone on calcitonin secretion in women with hyperprolactinemia and bone demineralization

Abstract

The objective of this study was to determine the bone mineral density and the pattern of fall in hip fracture patients. Method:The study was carried out on 260 patients (204 females and 56 males) with hip fractures over a period of three years. The mean age for males and females was 76.8 years and 77.7 years respectively. Information relating to their falls and hip fractures was collected.Bone mineral density of the contralateral intact femoral neck was measured by DXA. Results: Bone mineral density in patients with hip fractures was significantly lower than the fracture threshold value of 0.64 g/cma.The cervical to intertrochanterlc fracture ratio was 2.0 for females and 0.8 for males. 95.6% of the patients fell sideways, backward or straight down. 77% of the patients fell on hard surfaces such as ceramic, marble and concrete. 59% of the patients fell while walking. Conclusions: Low bone mineral density and falls are important risk factors in hip fracture in the elderly population. PSu208 R.ELRTZONSI'IIP ~ O~POROSZS AND ~OPAUSE T. G~ksow, O. Unal Sel~mice~ne 08teoporoBis & ]fenopause Center fstanhu} TURKEY F~-eg~ency. IE~-~ty. total bodybone mineral density (2~). luulbai Z-a bone mineral densit F {LZ-41I~D), femoral neck bone mineral density (FI~aD) of 152 women compared w~th 4921~tlents in~nopause. Bone mineral densl tymeasurement were made by DEY, A technique (dual eneFgY X-Fay e~crptlometry) in both groups. In our study ego, pregnancy and parity in menopeuse group were significantly higher than in the other group.(pr O1)In the whole body measurement group ego ~regnancy and paritywere s~gnificantIy higher and 2~w~s significantly lower in the menopause group. In fe~oral neck measurements, there wasn't any significant different ~n~arity (p (0,05) ]3etweon the two groups, but ~n them enopausegroup the age was significantly higher end the FI~ was significantly lower than the other group.In the LZ-aLl~measurement group, there wasn't any difference in the nu~er of the pregnancy between the two groupso(p<O. 05) ~us $n %hemeno~use92"cup. age and paritywere significantly higher and L2-4~ wee significently lower. (p< 0.05) Total body bone m~ms, femoral neck bone mass. end L2-4 spine bone mass measurements were statistically significantly lower in the meno~use group. These findings made us to think that the risk of osteoporos~s is significently higher in the monocle group and women in menopause must ~o followed up because of the risk of osteopoFosis and fracture in the femoral neck.Introduotlon.Some studies considered caloitonimllke peptide a potential PILL-inhiblting factor playing a possible physiologic role in the regulation of prolactln secretion. The aim of the present investigation was %o study the possible relatlanshlp between ~alcitonin,hyperprslaetlnemia and benedemineralization. Materials and methods.The serum basal caloltonin (CT) level and the sffec~ of thyrotropin-relsasing hormons(TRH) on oaloitonin ~d prolaotln seo~etion were determined in 20 female patients with hyperprolastinemla and bone deminerallzatio...