The authors followed up the incidence of permanent hypothyroidism in 35 patients with subacute thyroiditis (SAT) in their past history. The investigations were made one to four years after the acute episode. Ten of these presented repeated recurrences despite the therapy with glucocorticoids. The investigations included serum determination by RIA of T4, T3, TSH and thyroglobulin as well as of circulating thyroid antibodies. Permanent hypothyroidism subsequent to SAT occurred in two patients. In one of them it occurred following thyroid surgery performed for repeated recurrences. Both patients presented high levels of circulating thyroglobulin antibodies suggesting a possible transition to autoimmune thyroiditis. In the authors' opinion permanent hypothyroidism is likely to develop after SAT only in association with an autoimmune process or after thyroid surgery.

To identify and control renal factors affecting plasma homovanillic acid (HVA), a dopamine metabolite and an indicator of brain dopamine activity in clinical research, nine healthy subjects were studied on 5 nonconsecutive days. First study day was the baseline and on the other days base, salt, water, or probenecid loads were given. On each day serial concentrations of HVA and serotonin metabolite 5-hyroxyindoleacetic acid (HIAA), another organic anion, in plasma were measured. Results suggested that base, salt, and water loads did not affect plasma concentrations of either metabolite. Probenecid, which partially blocks renal organic anion transport, induced similar increases in plasma HVA and HIAA. When plasma HVA:HIAA ratio was used to control for the effect of probenecid, differences between baseline and probenecid days were no longer significant. Results suggest that HVA and HIAA are similarly handled by the kidney and that simultaneously measured plasma HIAA could be used to distinguish renal influences in plasma HVA studies.

The objective of this study was to determine the bone mineral density and the pattern of fall in hip fracture patients. Method:The study was carried out on 260 patients (204 females and 56 males) with hip fractures over a period of three years. The mean age for males and females was 76.8 years and 77.7 years respectively. Information relating to their falls and hip fractures was collected.Bone mineral density of the contralateral intact femoral neck was measured by DXA. Results: Bone mineral density in patients with hip fractures was significantly lower than the fracture threshold value of 0.64 g/cma.The cervical to intertrochanterlc fracture ratio was 2.0 for females and 0.8 for males. 95.6% of the patients fell sideways, backward or straight down. 77% of the patients fell on hard surfaces such as ceramic, marble and concrete. 59% of the patients fell while walking. Conclusions: Low bone mineral density and falls are important risk factors in hip fracture in the elderly population. PSu208 R.ELRTZONSI'IIP ~ O~POROSZS AND ~OPAUSE T. G~ksow, O. Unal Sel~mice~ne 08teoporoBis & ]fenopause Center fstanhu} TURKEY F~-eg~ency. IE~-~ty. total bodybone mineral density (2~). luulbai Z-a bone mineral densit F {LZ-41I~D), femoral neck bone mineral density (FI~aD) of 152 women compared w~th 4921~tlents in~nopause. Bone mineral densl tymeasurement were made by DEY, A technique (dual eneFgY X-Fay e~crptlometry) in both groups. In our study ego, pregnancy and parity in menopeuse group were significantly higher than in the other group.(pr O1)In the whole body measurement group ego ~regnancy and paritywere s~gnificantIy higher and 2~w~s significantly lower in the menopause group. In fe~oral neck measurements, there wasn't any significant different ~n~arity (p (0,05) ]3etweon the two groups, but ~n them enopausegroup the age was significantly higher end the FI~ was significantly lower than the other group.In the LZ-aLl~measurement group, there wasn't any difference in the nu~er of the pregnancy between the two groupso(p