Effect of Tiliacora triandra Leaf Extract on Glycemic Control in Mice with High Sugar Intake

Abstract

Prediabetes is associated with sugar-sweetened beverages and sugar-rich processed foods. High sugar intake (HSI), which is represented as save dose, may silently alter the glycemic control. The present study investigated the effect of HSI and Tiliacora triandra (TT21) leaf extract on the glycemic control in mice. Eighteen male ICR mice were divided into three groups of Control-HSI, HSI-TT300 and HSI-TT600 that received 4 weeks of 30% glucose with a vehicle of T. triandra leaf extract 300 and 600 mg/kg, respectively. The blood glucose, serum insulin, glucose clearance, liver and muscle glycogen contents and tissue oxidative status were evaluated. The results showed that HSI increased the blood glucose (w2 and w3: p<0.05) and serum insulin levels (w3 and w4: p<0.05) with glucose intolerance (w4: 30, 60 and 90 min, p<0.05). T. triandra leaf extract reduced the blood glucose and serum insulin and increased the glycogen content in the liver and muscle tissues (p<0.05). We concluded that HSI silently induced an alteration of the glycemic control in the normal mice, and the T. triandra leaf extract nurtured the glycemic control in the HSI mice by lowering the blood glucose and serum insulin and increasing the liver and muscle glycogen contents, which indicated an involvement of peripheral insulin sensitivity.

Study of Traditional Uses, Extraction Procedures, Phytochemical Constituents, and Pharmacological Properties of Tiliacora triandra

“…In addition, ong-asa et al [35] reported that T. triandra leaf extracts at 300 and 600mg/kg doses, Significantly restored motor coordination deficits induced by CISP and rats showed marked improvement in thermal/chemical hyperalgesia and mechanical allodynia [43] respectively, increased glycogen, whereas reduced blood glucose and serum insulin rates in muscle and liver in mice after administration for four weeks (Table 3). ese effects involved an enhancement in glucose clearance, a decrease in glucose intestinal absorption, and an increase in peripheral insulin sensitivity in comparison to high sugar intake mice that were used as a positive control for 4 weeks.…”

“…e n-hexane extracts of twigs of T. triandra were reported to exhibit promising nitric oxide, α-amylase, and α-glucosidase inhibition activities [3]. Furthermore, the leaf extract of this plant also demonstrated hypoglycemia in the mouse model that was fed with a high sugar intake followed by increased glycogen storage in both the liver and muscle and reduced serum insulin level [35].…”