Effect of Time-Lapse Administration of Panadol (Paracetamol) on Spleen and Kidney Functions of Adult Albino Mice

Abstract

Panadol is a remarkable pain and fever reducing non opioid drug. It is known to be completely safe and tolerant medicine throughout the globe among people of all age groups. The goal of this study was to elaborate the histopathological effects of reduced interrupted regime of panadol on spleen and kidney functions of mice (Mus musculus).
 The animals were categorized into four groups, the control group (C), and rest of the three were labeled as 1, 2 and 3, made on the basis of time interval of pandol administration via gavage (n=7). Matched volume of panadol (15000 µg/0.1ml) and normal saline was given to mice. Tissue samples were collected after sacrifice of the mice and processed for assessment.
 The findings of the current study reflected the histopathological damage of kidney and spleen caused by panadol in reduced interval of time. The kidney section illustrated clear distortion in glomeruli integrity, marked increase in interstitial spaces, damaged epithelia, and degeneration in tubules in all the groups. The spleen histology exhibited the degradation of white pulp, depopulation, activation of follicles, cellular disruption thereby overall disorganized stature. The raised values of serum creatinine and blood urea examinations also revealed the deleterious effects of panadol overconsumption.
 It is inferred from the above mentioned outcomes that though panadol is considered to be a safe drug even then its intake prior to four hours can account for adverse effects on kidney and spleen.

Ameliorative Effects of Saccharum officinarum (Sugarcane) Peel Extract against Paracetamol-Induced Disorders in Hematological Indices and Splenic Changes in Adult Male Sprague Dawley Rats

“…Excessive activity of cells and leukocytes may be due to tissue damage caused by drug overdose. 43 The results obtained for the histological examination of spleen tissues in all the groups (Figure 4) revealed that light microscopic images of rat spleen of Group I (control group) showed preserved architecture with lymphoid follicles (black arrow) and central arteriole (red arrow) as depicted in Figure 4A. Lymphoid follicle destruction, extensive hemorrhage (black arrows), and necrosis (red arrows) were revealed in Figure 4B.…”

Nauclea latifolia (smith) remediates the splenic architecture following paracetamol – induced toxicity in male Wistar rats

“…These toxicities resulted in the elevation of CD11b (+), infiltrating Ly6G (+), granulocytic and Ly6G (-) monocytic cells in the spleen and the liver (Mandal et al, 2016). Findings from Abbasi et al, (2018) reported white pulp degradation, depopulation and activation of follicles and cellular disruption in the spleen with overall disorganized stature of the organ. It is assumed that paracetamol influences the physiology of some organs, including the spleen.…”