Effect of Timing of Pulmonary Metastases Identification on Prognosis of Patients With Osteosarcoma: The Japanese Musculoskeletal Oncology Group Study

Tsuchiya, Hiroyuki; Kanazawa, Yoshimitsu; Abdel-Wanis, Mohamed E.; Asada, Naohiro; Abe, Satoshi; Isu, Kazuo; Sugita, Takashi; Tomita, Katsuro

doi:10.1200/jco.2002.11.028

Cited by 151 publications

(111 citation statements)

References 33 publications

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“…In two more recent series, a benefit for second-line chemotherapy was not demonstrated. Tsuchiya et al 25 reported similar overall survival for patients with pulmonary recurrence treated with surgery alone or with second-line chemotherapy and surgery.Ferrari et al 26 reported no difference in overall survival between patients treated with or without second-line chemotherapy after first disease recurrence-.For patients with completely excised isolated pulmonary recurrence, there was no difference in second event-free survival with the addition of chemotherapy. A subgroup analysis of patients with completely excised isolated pulmonary recurrence showed a superior 5-year survival with surgery alone compared with surgery and second-line chemotherapy.…”

Section: Discussionmentioning

confidence: 91%

“…Inability to achieve CR2 has been associated with an exceptionally poor outcome, with overall survival rates ranging from 0% to 8%. 8,9,11,13,19,20,25,26 Goorin et al 12 reported a survival rate of 32% (7 of 22 patients) among patients with unresectable recurrent OS, although the duration of follow-up was not reported. Improved survival has also been associated with prolonged RFI, variably de- fined as longer than 6 months, 9 longer than 8 months, 16 and longer than 24 months.…”

Section: Discussionmentioning

confidence: 99%

“…4 -26 The benefit of secondline chemotherapy in the treatment of recurrent OS is less clear. [7][8][9][10][11][12][13]15,16,19,20,25,26 Several factors complicate the analysis of the published literature regarding DFS and survival after OS recurrence. First, some series represented selected cohorts of patients amenable to surgical excision, thereby excluding patients with unresectable (and therefore unfavorable) recurrent tumors.…”

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confidence: 99%

“…4,5,9,13,16 -19 Third, the chemotherapy given to patients who received neoadjuvant or adjuvant treatment often differed significantly from regimens used currently, including relatively inactive or nonintensive agents, 6 -13,15-21,23,24 or were accompanied by inadequate descriptions of the chemotherapy regimens. 25 Fourth, most series reported only survival rates and only three series reported DFS or event-free survival rates after disease recurrence. 12,15,26 Those rates ranged from 16% to 27%.…”

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confidence: 99%

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Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy

Hawkins

Arndt

2003

Cancer

139

120

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BACKGROUNDThe goal of the current study was to define the clinical features and outcome of recurrent osteosarcoma (OS) in children and young adults initially treated with contemporary chemotherapy.METHODSThe authors reviewed the clinical features, therapy, and outcome for 59 patients from the Mayo Clinic (Rochester, MN) and Children's Hospital and Regional Medical Center (Seattle, WA). They were diagnosed initially with OS between January 1990 and December 2000, received multiagent chemotherapy (most frequently cisplatin, doxorubicin, high‐dose methotrexate, and ifosfamide), and developed disease recurrence after achieving an initial complete response (CR).RESULTSThe most common site of initial disease recurrence was the lung only (n = 36 patients), followed by distant bone (n =8 patients), combined lung and other sites (n =7 patients), and other sites (n =8 patients). The median time to first disease recurrence was 15 months (range, 2–92 months) from the initial diagnosis. Thirty patients with isolated pulmonary recurrence achieved a second CR, either with surgery alone (n =15 patients) or surgery and salvage chemotherapy (n =15 patients). For this group, the 4‐year disease‐free survival (DFS) and overall survival rates were 7% (95% confidence interval [95% CI], 0–16%) and 28% (95% CI, 11–45%), respectively. For all 59 patients with recurrent OS, the 4‐year DFS and overall survival rates were 6% (95% CI, 0–12%) and 23% (95% CI, 10–36%), respectively. The only factors associated with improved DFS and overall survival rates were unilateral pulmonary recurrence, solitary pulmonary nodule at recurrence, more than 24 months between the initial diagnosis and first disease recurrence, and achievement of a second CR.CONCLUSIONSThe DFS and overall survival rates for recurrent OS after contemporary therapy remained poor even for patients with isolated pulmonary recurrence. Therefore, new treatment strategies are needed. Cancer 2003. © 2003 American Cancer Society.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy

Hawkins

Arndt

2003

Cancer

139

120

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“…The 5-year survival rate after the detection of lung metastasis is less than 30%. 14 Despite recent improvements in chemotherapy and surgery, the current strategies for the treatment of high-grade OS do not improve significantly the outcome for the patient.…”

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Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis

Cambien

Rezzonico

Vitale

et al. 2008

Intl Journal of Cancer

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Potassium channels, the most diverse superfamily of ion channels, have recently emerged as regulators of carcinogenesis, thus introducing possible new therapeutic strategies in the fight against cancer. In particular, the large conductance Ca 21 -activated K 1 channels, often referred to as BK channels, are at the crossroads of several tumor-associated processes such as cell proliferation, survival, secretion and migration. Despite the high BK channel expression in osteosarcoma (OS), their function has not yet been investigated in this malignant bone pathology. Here, using stable RNA interference to reduce the expression of hSlo, the human pore-forming a-subunit of the BK channel, in human Cal72 OS cells, we show that BK channels play a functional role in carcinogenesis. Our results reveal for the first time that BK channels exhibit antitumoral properties in OS in vivo and affect the tumor microenvironment through the modulation of both chemokine expression and leukocyte infiltration. ' 2008 Wiley-Liss, Inc.Key words: osteosarcoma; ion channels; xenografts; chemokines; tumor microenvironmentThe development of cancer is a multistep process that usually occurs over many decades. This process encompasses the alteration of genes and/or proteins involved in fundamental cellular mechanisms like proliferation, apoptosis and differentiation. There is mounting evidence pointing to the involvement of ion channels in cancer progression. 1 The most compelling evidence regarding the involvement of ion channels in the transformation process relates to the over-expression of voltage-gated K channels in a variety of cancers. Among them are the large conductance Ca 21 -activated K 1 channels, often referred to as BK channels (for Big K). Indeed, we and others have shown that BK channels are a unique class of ion channels that are activated by a change in intracellular calcium, in voltage 2 and by a wide variety of molecules and molecular mechanisms including growth factors and hypoxia that, interestingly, are involved in carcinogenesis. [3][4][5][6] BK channels are expressed in a broad spectrum of cells in which they play a crucial role in neurotransmitter release, muscle relaxation 7,8 and diverse activities involved in tumor-associated processes such as cell proliferation, survival, secretion and migration. [9][10][11] Importantly, in human glioma, BK channels are significantly up-regulated, and their expression levels seem to correlate positively with tumor grade and poor patient prognosis. In vitro studies have suggested a role for BK channels in the control of glioma cell growth, survival and migration. 4,11 In addition glioma, we have shown a high level of BK expression in osteosarcoma (OS). 12 Altogether, these studies suggest an important role for BK in carcinogenesis and point to its potential value as a prognostic marker and/or a therapeutic target. To date, however, none of these aspects have been addressed in vivo.OS is the most common malignant bone tumor in children and adolescents. 13 OS is characterized by a hig...

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Fracture behavior of carbon fiber reinforced plastics determined by the time–frequency analysis method

Nam

Ahn

Moon

2003

J of Applied Polymer Sci

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Fourier transform has been used to study the frequency characteristics of a signal. However, based on the Fourier transform and power spectrum alone, it is hard to tell whether or not the frequency content of a signal evolves over time, even though the phase of the Fourier transform relates to time shifting. On the other hand, except for a few special cases, the frequency content of the majority of signals encountered in the real world change with time. Recently, to overcome the problem that Fourier transform is unable to represent a nonstationary signal, time-frequency analysis methods that can simultaneously represent information about the time and frequency of a signal have been developed. In this study, the damage process of cross-ply carbon fiber reinforced plastics (CFRP) during a monotonic tensile test was characterized by acoustic emission (AE). Different laminated types of CFRP were used to determine the characteristics of the AE signal and frequency. The time-frequency analysis method was found to be useful for the determination of the fracture mechanism in CFRP (such as, matrix cracking, debonding-delamination, and fiber fracture).

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Effect of Timing of Pulmonary Metastases Identification on Prognosis of Patients With Osteosarcoma: The Japanese Musculoskeletal Oncology Group Study

Cited by 151 publications

References 33 publications

Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy

Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy

Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis

Fracture behavior of carbon fiber reinforced plastics determined by the time–frequency analysis method

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