Effect of topical prostaglandins on the biomechanics and shape of the cornea

Amano, Shiro; Nejima, Ryohei; Inoue, Kenji

doi:10.1007/s00417-019-04435-7

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…In a cross-sectional study using Casia OCT by Amano et al in 2019, when PGA eyedrops were used in patients with open-angle glaucoma without corneal disease or surgery, there were changes in the biomechanical factors of the cornea, including CCT. Still, there was no change in the shape itself [36]. However, due to the effects of PGA eyedrops on the cornea other than CCT reduction, Amano et al in 2008 reported a case in which the disease progressed after PGA eyedrop treatment in a keratoconus patient [37].…”

Section: Discussionmentioning

confidence: 99%

Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review

Kim

Yim

2022

JCM

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To investigate whether prostaglandin analogue (PGA) eyedrops have a significant effect on central corneal thickness (CCT), we conducted a systematic search of literature published from 2000 to 2021. Among the studies conducted on topical PGA therapy in open-angle glaucoma or ocular hypertension patients over 18 years old, prospective studies with CCT change as an outcome were included. A single-arm meta-analysis was conducted to assess the overall effect on CCT, and subgroup analysis according to exposure time of PGA eyedrops was also performed. We counted the number of articles that reported on severe events (CCT reduction of 25 μm or more) and obtained their proportion. The methodological quality was assessed by the McHarm tool. Twenty-two reports of prospective studies were selected. The results of the single-arm meta-analysis showed very high heterogeneity. Still, in subgroup analysis, when PGA was used for more than 6 months, heterogeneity was low, and a significant decrease in CCT was observed. Severe events were reported in two reports and occurred in 3.8% to 14.8% of participants. PGA eyedrop use may cause a clinically significant CCT decrease, requiring CCT follow-up.

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Section: Discussionmentioning

confidence: 99%

Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review

Kim

Yim

2022

JCM

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“…Although the patients were taking a prostaglandin analog, the magnitude of the observed effect is unlikely to be accounted for by the effect of the prostaglandin analog on corneal biomechanics. 21 It is more probable that the difference may reflect greater resistance in outflow and or differences in scleral rigidity in eyes with glaucoma. 22 Aqueous outflow facility is known to fluctuate and change.…”

Section: Discussionmentioning

confidence: 99%

Influence of Corneal Visualization Scheimpflug Technology Tonometry on Intraocular Pressure

Borroni

Gadhvi

Hristova

et al. 2021

Ophthalmology Science

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Purpose: To investigate the effect of Corneal Visualization Scheimpflug Technology tonometry (CST) on intraocular pressure (IOP).Design: Cohort study.Participants: Patients with and without primary open-angle glaucoma (POAG) were included. Methods: Intraocular pressure was measured using the Icare rebound tonometer (ICRT; Icare Finland Oy) and the biomechanically corrected IOP (bIOP) using the CST. Intraocular pressure was measured at baseline with ICRT, followed by a CST measurement in one eye with the fellow eye acting as a control. Icare measurements were repeated at 10 seconds and 1, 2, 4, 8, 15, 30, and 60 minutes in both eyes. The ratio of test eye IOP to fellow eye IOP was used to control for intrasubject variation.Main Outcome Measures: Intraocular pressure change following Corneal Visualization Scheimflug Technology tonometry.Results: Forty participants (mean age, 54.09 AE 20.08 years) were included comprising 20 patients with POAG and 20 patients with no ocular abnormalities other than cataract. Mean central corneal thickness was similar in those without POAG (547.4 AE 55.05 mm) and with POAG (520.22 AE 37.59 mm; P ¼ 0.14). No significant change was found in IOP measured with the ICRT in the fellow eye versus the 1-hour period in either the healthy (P ¼ 0.87) or POAG (P ¼ 0.92) group. Significant changes were found in IOP after CST measurement for both healthy (P < 0.01) and glaucomatous (P < 0.01) eyes. After the CST measurement, the IOP reduced continuously from a mean of 13.75 mmHg to 10.84 mmHg at 4 minutes for healthy eyes and from 13.28 mmHg to 11.11 mmHg at 8 minutes for glaucomatous eyes before approaching (83% for healthy eyes and 92% POAG eyes) the pre-CST measurement at 1 hour.Conclusions: Corneal Visualization Scheimpflug Technology tonometry causes a significant reduction in IOP in both glaucomatous and healthy eyes that lasts for at least 1 hour afterward. Ophthalmology

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“…Both are modified pneumotonometers that measure timing or visualization of corneal applanation and use this to calculate energy absorption or characteristic shape changes of the cornea. 3,4 Studies using the ORA reported negligible changes in the biomechanical parameter, corneal hysteresis (CH) following CXL. [5][6][7] Likewise, the Corvis ST demonstrated no significant long-term changes in its corneal biomechanical parameters following CXL, except some early changes at one month.…”

Section: Introductionmentioning

confidence: 99%

Corneal Crosslinking Biomechanics Evaluated by a Novel and Easily Implemented Differential Tonometry Method

Wang

Berdahl

McCafferty

2021

Current Eye Research

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Purpose: Evaluate potential corneal biomechanical changes following corneal crosslinking (CXL) by paired differential tonometry intraocular pressure (IOP) measurements with a Goldmann tonometer (GAT) prism and corneal compensating, correcting applanation tonometry surface (CATS) prism. Methods: IOP was measured prospectively on 23 unique eyes undergoing CXL for keratoconus with a GAT using a standard flat GAT prism and a curved corneal error correcting CATS prism before treatment and at 2 weeks, 2 months and 6 months after treatment. Concurrent measurements of central corneal thickness (CCT) and corneal hysteresis (CH) were completed. Results: Paired IOP measurements with standard GAT and corneal correcting CATS prisms indicated a significant sustained relative increase in the differential IOP between the two prisms after CXL (p = .002,0.051,0.062). CH initially decreased at two weeks post-CXL then returned to sustained pre-op levels (p = .033,0.20,0.20). CCT progressively decreased following CXL (p = .005). Discussion: Differential tonometry between standard GAT and corneal biomechanical compensating CATS prisms indicates findings consistent with increased corneal rigidity following CXL and may demonstrate a simple and sensitive method for measurement of relative corneal biomechanical changes due to pharmacologic agents and procedures.

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Effect of topical prostaglandins on the biomechanics and shape of the cornea

Cited by 13 publications

References 15 publications

Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review

Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review

Influence of Corneal Visualization Scheimpflug Technology Tonometry on Intraocular Pressure

Corneal Crosslinking Biomechanics Evaluated by a Novel and Easily Implemented Differential Tonometry Method

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