Effect of topically applied Saccharomyces boulardii on the healing of acute porcine wounds: a preliminary study

Abstract

BackgroundNormal wound healing progresses through a series of interdependent physiological events: inflammation, angiogenesis, re-epithelialization, granulation tissue formation and extracellular matrix remodeling. Alterations in this process as well as the bacterial type and load on a wound may alter the wound healing rate. The purpose of this study was to evaluate the effect of topical Saccharomyces boulardii on the healing of acute cutaneous wounds, using a prospective, controlled, experimental study, with six purpose bred landrace pigs.ResultsAll wounds healed without apparent complications. Comparison of the mean 3D and 2D wound surface area measurements showed no significant difference between treatment groups as wounds decreased similarly in size over the duration of the study. A significant reduction in wound surface area was identified sooner using 3D assessments (by day 9) compared to 2D assessments (by day 12) (P < 0.001). There was no significant effect of treatment group on the number of multiple isolates or the most common isolates obtained relative to control wounds. There was no histologically appreciable difference between the wounds of the different groups.ConclusionsTopical application of Saccharomyces boulardii does not hasten wound healing or change the wounds’ microbiome under the conditions reported in this study.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2012-8) contains supplementary material, which is available to authorized users.

The role of topical probiotics on wound healing: A review of animal and human studies

“…In these studies, the mechanism of action was typically not explored, but topical probiotic treatment resulted in improved healing as demonstrated by increased granulation tissue deposition, improved collagen concentration, and stimulation of angiogenesis. [33][34][35][36][37][38][39][40][41][42] However, not all models demonstrated an improvement in topical wound healing with probiotics [33][34][35][36][37][38][39][40][41][42][43][44] (Tables 1 and 2).…”

“…They were able to reduce the erythema and oedema associated with CO 2 laser therapy, reduce skin sensitivity in patients with reactive skin, and increase ceramide concentration and skin hydration. [82][83][84][85] However, not all studies investigating topical probiotics have demonstrated superiority compared with traditional interventions 43,44 (Table 2).…”

Avoidance of milk and dairy products after oral surgery—is such a recommendation still valid? A cross-sectional study among German and international oral and maxillofacial surgeons and dental practitioners with review of the literature

“…Diametrically opposed the situation in the Germanspeaking and related regions (e.g., Flanders in Belgium): in our German survey, a slight majority (56.1%) was reported to advise their patients against consumption of milk and dairy products [6], with a significant difference between dentists and OMFS in Germany (p = 0.027) (see Table 7), of which those with a focus on surgical procedures attributed at least a minor positive effect on wound [10] Animal model study L. brevis and L. plantarum Decreased inflammation and improved wound healing Jones, 2012 [11] Animal model study L. fermentum Enhanced wound healing Poutahidis, 2013 [12] Animal model study L. reuteri Enhanced wound healing Partlow, 2016 [14] Animal model study S. bouladrii Unimproved wound healing, unchanged microbiome Argenta, 2016 [15] Animal model study L. plantarum Decreased mortality and production of inflammatory markers (TNF-α, IL 6 and 10), less septicemic accumulation in organs Satish, 2017 [16] Animal model study L. plantarum Reduced severity and length of infection and collagen concentration (less scarring) Oryan, 2018 [17] Animal model study S. cerevisiae Enhanced burn wound healing Ong, 2019 [18] Animal model study L. plantarum Enhanced wound healing, suppressed Staphylococcus aureus infection at wound Tagliari, 2019 [19] Animal model study L. paracasei, B. lactis, L. rhamnosus, L. acidophilus…”

Time-Dependent Displacement of Commensal Skin Microbes by Pathogens at the Site of Colorectal Surgery

“…Early identi cation of postoperative skin dysbiosis may then allow for preventive measures to restore a normal skin microbiota. For example, topical probiotic therapy has now been embraced as a method to optimize the skin microbiome 38,39 . Other available interventions to modulate the skin microbiota include topical application of honey-based ointments or the use of enteral probiotics.…”