Effect of total body x-irradiation on some enzymes of rat tissues

Roth, Jay S.; Eichel, Herbert J.; Wase, Arthur W.; Alper, Carl; Boyd, Meagan

doi:10.1016/0003-9861(53)90011-3

Cited by 17 publications

(2 citation statements)

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“…1953b). These observations with protozoan enzymes are consistent with the recent reports that the activities of SH-dependent enzymes are frequently not altered in the tissues of mammals exposed to high levels of x-or T-radiation (LeMay, 1951;Roth et al, 1952;Thomson et al, 1952;Ashwell and Hickman, 1952;Roth et al, 1953).…”

Section: Succinic Dehydrogenasesupporting

confidence: 90%

The Effect of X-Radiation on Enzyme Systems of Tetrahymena Pyriformis ,

Roth

Eichel

1955

The Biological Bulletin

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It had been shown previously by Eichel and Roth (1953b) that x-radiation at a level of 300,000 or 500,000 r depressed the respiration of Tetrahymena pyriformis W, 3 but did not appreciably affect the nuclease activity in homogenates prepared from irradiated whole cells. In irradiated homogenates, however, nuclease activity was reduced by approximately 50%. This paper presents some further observations of the effect of 300,000 to 600.000 r on respiration and several enzymes of T. pyriformis S. The S strain was chosen for two reasons; first, to obtain comparisons of the effect of x-radiation on respiration and deoxyribonuclease (DNase) activity in a strain different from that studied previously, and second, because the higher rate of succinate oxidation in the S strain (Eichel, 1954) would facilitate investigations of this specific enzyme system. The effects of x-radiation on catalase, and malic, glutamic, and succinic dehydrogenases, as well as some properties of succinic dehydrogenase and DNase, have also been observed. In addition, the effect of x-radiation on the oxidation of L-phenylalanine and acetate by the W strain has been studied.

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