Effect of total lung capacity, gender and height on CT airway measurements

Abstract

√WAPi10, WT and WT are different in males and females. WT and WT are correlated with height in females only but not with TLC or in males. Advances in knowledge: CT airway measurements are influenced by gender and by height in females only but not by TLC. They should be adjusted according to gender and height in females.

Radiomics in Lung Diseases Imaging: State-of-the-Art for Clinicians

“…Quantitative CT metrics of airways include the study of wall thickness, area and density, and lumen diameter and area. However, its use faces a certain number of limitations, as airway metrics are highly influenced by lung volume, aging and inflammation [ 60 ]. Therefore, applying airway metrics in clinical practice is still at the preliminary stage.…”

Rib cage anatomy in Homo erectus suggests a recent evolutionary origin of modern human body shape

“…We also compared the virtual 3D reconstructions of the KNM-WT 15000 thoraces (juvenile and adult) with the modern human reference sample using measured maximum width, depth and height. We calculated total lung capacity of the KNM-WT 15000 reconstructed thoraces following the methods presented in García-Martínez et al 54 , but we included a male sample only (Supplementary Table 1; n = 40; mean age, 21 years; mean stature, 180.37 cm; mean total lung capacity (TLC), 7.77 l) 72 and compared these values to published reference data 73 . Thoracic spine length was used to estimate the stature of KNM-WT 15000 in juvenile and adult individuals following Nagesh and Pradeep Kumar 74 (Supplementary Table 6).…”

Pulmonary quantitative CT imaging in focal and diffuse disease: current research and clinical applications

“…Quantitative analysis of the airway follows the preliminary processing step of bronchial tree segmentation and isolation of three-dimensional airway model 89,90 (Figure 4a-c). Airway is usually quantified according to its generation, and the generation-specific mean can be calculated throughout the entire lung, 91 nonetheless, Gupta et al reported that a single bronchus might be representative. 92 Direct characterization of airway is feasible for several bronchial generations, 93 yet, direct QCT metrics are widely accepted up to fifth generation.…”

“…The variability and potential bias of airway metrics are significant and include lung volume, age and transient inflammation. 91,97 For this reason, the clinical application of airway QCT is still to be validated. 4 Pi10 is deemed the most consistent among airway metrics, albeit only when calculated on a minimum of 12 subsegmental bronchi.…”