Effect of Tramadol Versus Fentanyl on Some Hematological and Serum Biochemical Parameters in Dogs

Hamad, Amal A.; Torad, Faisal A.; Thabet, Nahed S.; Gadallah, Shaaban

doi:10.5455/ajvs.231096

Cited by 3 publications

(2 citation statements)

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“…Several studies with diverging perspectives have revealed the effect of tramadol on immunological cells and markers [27][28][29] and the observation that anesthetics may affect the function of immune cells has been established [8] . Similarly, oral contraceptives have been associated with low and inflammatory status [30] .…”

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confidence: 99%

In vitro cytotoxic and inhibitory effect of tramadol, flunitrazepam and levonogestrel on neutrophils and myeloperoxidase

Oyewo,

Ajayi,

Oso

et al. 2024

Trends Immunother.

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The abuse of flunitrazepam, tramadol and levonorgestrel among adolescents is a major problem, with adverse effects on the immune system. Neutrophils serve as the host primary defense and employ the role of an essential enzyme, myeloperoxidase. This study investigated the in vitro effect of flunitrazepam, tramadol and levonorgestrel on the activity of the neutrophil. Neutrophils were isolated from blood samples of volunteers and seeded in culture plates, and then treated with flunitrazepam, tramadol and levonorgestrel. Trypan blue exclusion assay was used to assess the cytotoxic effect of flunitrazepam, (15, 150, 1500, 15,000, 150,000 ng/mL), tramadol (300, 3000, 30,000 µg/ml) and levonorgestrel (18.5, 185 and 1850 ng/mL) on the neutrophils, and the effect flunitrazepam (150,000 ng/mL), tramadol (30,000 µg/ml) and levonorgestrel (1850 ng/mL) on myeloperoxidase activity was assessed. The viability of neutrophils treated with flunitrazepam, (15,000, 150,000 ng/mL), tramadol (300, 3000, 30,000 µg/ml) and levonorgestrel (18.5, 185 and 1850 ng/mL) decreased significantly (p < 0.05) compared with control. Myeloperoxidase activity in neutrophils treated with flunitrazepam (150,000 ng/mL), tramadol (30,000 µg/ml) and levonorgestrel (1850 ng/mL) decreased significantly (p < 0.05) compared with background and positive control. This study revealed that flunitrazepam, tramadol and levonorgestrel altered the activity of myeloperoxidase and phagocytic activities of the neutrophil.

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Section: Introductionmentioning

confidence: 99%

In vitro cytotoxic and inhibitory effect of tramadol, flunitrazepam and levonogestrel on neutrophils and myeloperoxidase

Oyewo,

Ajayi,

Oso

et al. 2024

Trends Immunother.

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“…Stimulation of immune cells and molecules could be directed at foreign bodies and at times on self. The effect of tramadol on immunological cells and markers have been studied with a diverging perspectives, though with different study animals and narratives (Sacerdote et al, 2000;Liu et al, 2006;Sacerdote et al, 1997;Hamad et al, 2016). Some of the studies posited that tramadol intoxication has significant effects on some immunological parameters, whereas others are of contrary opinion.…”

Section: Introductionmentioning

confidence: 99%

Chronic and Acute Effect of Tramadol Intoxication on Some Immunological Parameters

Zebedee¹,

Jeremiah²,

Nyebuchi³

et al. 2021

American Journal of Immunology

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Tramadol intoxication is rapidly on the increase in Nigeria with unestablished short-term and long-term effects. The study was aimed at elucidating the dose-dependent effect of acute or chronic tramadol intoxication on some immunological parameters using male rats (Rattus norvegicus). A total of fifty adult rats were used for the study as indicated by Mead's Resource Equation. The study consisted of acute and chronic categories of fifty adult rats randomly pair-divided into groups of six rats each. The acute phase consisted of a control group of 6 rats administered with normal saline solution and a treatment group of 6 rats administered with lethal dose of tramadol. The chronic phase comprised of control group of 6 rats and 3 tramadol-dependent groups of 6 rats each administered orally with 50, 100 and 200 mg/kg of tramadol for a period of 90 days respectively. Student t-test, one-way Anova and Pearson correlations were the statistical tools used for the data analysis employing JMP statistical discovery™ software version 14.1. Blood samples were collected by cardiac puncture for immunological examination using World Health Organization (WHO) approved methods. The study revealed that concentrations IgG, IgM and CD4 were significantly elevated (p>0.05) in the acute treatment group compared with the controls. However, the chronic phase of the study showed a progressive significant increase (p>0.05) in CD4 count. Conclusively, the study has demonstrated that tramadol intoxication has the preponderances of altering the immune apparatuses of the body.

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The effect of tramadol on blood glucose concentrations: a systematic review

Nakhaee

Brent

Hoyte

et al. 2020

Expert Review of Clinical Pharmacology

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Effect of Tramadol Versus Fentanyl on Some Hematological and Serum Biochemical Parameters in Dogs

Cited by 3 publications

References 0 publications

In vitro cytotoxic and inhibitory effect of tramadol, flunitrazepam and levonogestrel on neutrophils and myeloperoxidase

In vitro cytotoxic and inhibitory effect of tramadol, flunitrazepam and levonogestrel on neutrophils and myeloperoxidase

Chronic and Acute Effect of Tramadol Intoxication on Some Immunological Parameters

The effect of tramadol on blood glucose concentrations: a systematic review

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