Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats

Karimi‐Sales, Elham; Jeddi, Sajad; Ghaffari-Nasab, Arshad; Salimi, Mina; Alipour, Mohammad Reza

doi:10.2478/enr-2018-0001

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…At the end of treatments, the animals were kept fasted (overnight) for 12 h, and fasting blood glucose (final blood glucose) was measured by a digital glucometer (Gluco Sure, Star, Taiwan). Then, all rats were deeply anesthetized by ketamine (60 mg/kg) and xylazine (10 mg/kg) (21), and afterwards, blood samples were collected and stored at deep freeze (-70°C). Moreover, heart samples were immediately removed, frozen in liquid nitrogen, and stored at -70°C for later measurements.…”

Section: Tissue Sampling and Preparation Of Heart Homogenatementioning

confidence: 99%

Immunomodulator Drug (IMODTM) and Exercise Improve Cardiac Oxidative Stress and Antioxidant Balance in Diabetic Rats

Ali-Aghdam

Karimi‐Sales

Mahmoudi

et al. 2020

Jundishapur J Nat Pharm Prod

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: Diabetes is a common metabolic disease that increases the risk of cardiovascular disease. It seems that the reduction of oxidative stress or increasing antioxidant levels improves diabetic cardiomyopathy. Antioxidant effects of immunomodulatory drug (IMODTM) and also beneficial influences of exercise on diabetic complications have been shown. The present study examined the effects of IMODTM and exercise on cardiac oxidative stress and antioxidants in diabetes. For this purpose, 64 rats were divided into 8 groups: control (C), exercise (E), IMODTM (20 mg/kg) (I), exercise plus IMODTM (E + I), diabetes (D), diabetic rats treated with exercise (D + E), diabetic rats treated with IMODTM (D + I), and diabetic rats treated with exercise plus IMODTM (D + E + I). Treatments with exercise and/or IMODTM were performed for 8 weeks. Type 1 diabetes was induced by intraperitoneal injection of 60 mg/kg streptozotocin. After the treatment period, all rats were anesthetized, and blood and heart samples were gathered for measurement of malondialdehyde (MDA) as an oxidative stress marker, lactate dehydrogenase (LDH) as a cardiac injury marker, total antioxidant capacity (TAC), and superoxide dismutase (SOD) as well as glutathione peroxidase (GPx) as antioxidant enzymes. The present study, for the first time, showed that IMODTM alone or in combination with exercise had positive effects on alleviating hyperglycemia, MDA, and LDH along with elevation of antioxidant enzymes activities in type 1 diabetic rats.

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Section: Tissue Sampling and Preparation Of Heart Homogenatementioning

confidence: 99%

Immunomodulator Drug (IMODTM) and Exercise Improve Cardiac Oxidative Stress and Antioxidant Balance in Diabetic Rats

Ali-Aghdam

Karimi‐Sales

Mahmoudi

et al. 2020

Jundishapur J Nat Pharm Prod

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“…Plants including Aniba riparia, Piper methysticum, and Didymocarpus corchorijolia can produce trans -chalcone , It targets the expression of TGF-β and ICAM-1, as well as STAT3 and NF-κB modulation, to prevent ischemia-induced retinal neovascularization .…”

Section: Introductionmentioning

confidence: 99%

“… 5 Trans- chalcone, an open-chain flavonoid, has antifibrotic, antioxidant, antidiabetic, hepatoprotective, and anti-inflammatory impacts. 6 , 7 It targets the expression of TGF-β and ICAM-1, as well as STAT3 and NF-κB modulation, to prevent ischemia-induced retinal neovascularization. 8 Trans -chalcone reduces hepatic fibrosis and inflammation driven by acetaminophen and carbon tetrachloride by lowering the generation of nitric oxide, TGF-β, and TNF-α, lipid peroxidation, and diminished glutathione deprivation.…”

Section: Introductionmentioning

confidence: 99%

Trans-Chalcone (1–3-diphenyl-2-propen-1-one) as a Therapeutic Candidate in Joint Inflammation via Reduction of TNF-α, IL-1β, IL-6, and IL-17 in Rodents: An In Vivo Study by RT-PCR and ELISA analysis

Jabbar,

Irfan,

Alamgeer

et al. 2024

ACS Omega

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Autoimmune disorders include vast and distinct illnesses and are characterized by an immune system-mediated attack on the body’s own tissues. Because of their ability to impact any portion of the body, their clinical symptoms are incredibly varied. The variations in symptoms are normally linked with the release and activation of vasoactive, chemotactic substances and cytokines. Cytokines perform a multitude of vital biological tasks, such as immune response control, inflammation, proliferation, and tissue repair. The reversal of inflammatory cytokines and leukocyte infiltration into the inflamed tissue by natural compounds provides an effective remedy for autoimmune diseases. Here, the oral administration of trans-chalcone (TC) for 28 days was tested with gradually increasing doses (30, 60, and 120 mg/kg) in complete Freund’s adjuvant (CFA)-provoked joint tissue stiffness in rats. Paw edema, arthritic index, joint stiffness, thermal and flexion pain, C-reactive protein, and rheumatoid factor (RF) levels were determined to check the tested drug effectiveness in a chronic inflammatory model. Molecular docking studies revealed strong binding affinity with inflammatory cytokines and mediators such as TNF-α, IL-17, COX-2, and iNOS; further, they were quantified at the mRNA level by RT-PCR and ELISA analysis. Oral administration of TC significantly ameliorated paw edema, thymus and spleen indices, joint stiffness, thermal and flexion pain, C-reactive protein, RF, mobility, and stance of the treated animals. This therapeutic effectiveness was linked with a reduction in the mRNA expression of proinflammatory cytokines such as IL-1β, IL-6, and IL-17. The findings of the reported research confirmed the effectiveness of TC in ameliorating joint stiffness and flexion pain by prominently lowering the inflammatory cytokines.

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Atheroprotective and hepatoprotective effects of trans-chalcone through modification of eNOS/AMPK/KLF-2 pathway and regulation of COX-2, Ang-II, and PDGF mRNA expression in NMRI mice fed HCD

et al. 2022

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Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats

Abstract: Based on the results of present study, miR-451/IL-8 pathway is a possible mechanism for hepatoprotective action of trans-chalcone in long-term.

Cited by 7 publications

References 23 publications

Immunomodulator Drug (IMODTM) and Exercise Improve Cardiac Oxidative Stress and Antioxidant Balance in Diabetic Rats

Immunomodulator Drug (IMODTM) and Exercise Improve Cardiac Oxidative Stress and Antioxidant Balance in Diabetic Rats

Trans-Chalcone (1–3-diphenyl-2-propen-1-one) as a Therapeutic Candidate in Joint Inflammation via Reduction of TNF-α, IL-1β, IL-6, and IL-17 in Rodents: An In Vivo Study by RT-PCR and ELISA analysis

Atheroprotective and hepatoprotective effects of trans-chalcone through modification of eNOS/AMPK/KLF-2 pathway and regulation of COX-2, Ang-II, and PDGF mRNA expression in NMRI mice fed HCD

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