Effect of Trans Fatty Acid on Glucose Level and Pancreatic β Cell in Rats

Sartika, Ratu Ayu Dewi; Achmad, K.; Triyanti,; Rustika,

doi:10.3923/pjn.2016.760.762

Cited by 2 publications

(4 citation statements)

References 16 publications

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“…Giving high-fat ration to mice can affect the expression of pancreatic β cell genes which can cause abnormality and programmed cell death of pancreatic β cells (Dusaulcy et al, 2019).. This matter is in accordance with the research of Sartika et al (2016) that there was a change in the number of normal β cells to be reduced in the pancreas of Wistar rats given trans-fatty acids. This is supported by the opinion that trans-fat is believed to be a source of oxidative stress is a condition in which there is an excess of ROS which are free radicals because of instability the betwen producing rate and the ROS disposal rate due to excess ROS production (Martin et al, 2007& McMichael, 2007.…”

Section: Resultssupporting

confidence: 78%

“…Trans-fatty acids can increase LDL cholesterol levels, but at the same time reduce HDL cholesterol levels (Tuminah, 2009). Sartika et al (2016) through their research revealed that there was a reduce in the number of normal β cells pancreas of Wistar rats which were fed with trans-fatty acids. This study was supported by Dusaulcy et al (2019) who stated that feeding highfat feeds to white mice could affect the expression of pancreatic β cell genes which could cause pancreatic β cell dysfunction and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

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Blood-Glucose Levels of Rats Given High-Fat Diets after Administration of Neem Leaf Ethanolic Extract

2021

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Azadirachta indica A. Juss (Neem) is a medicinal plant that contains antioxidants, antihyperlipidemia, and has antidiabetic activity. This research aimed to examine the effect of neem leaf ethanolic extract on blood glucose levels of white rats given high-fat rations. The male white rats (Rattus norvegicus L.) with two months of age were used. The treatment of test animals consisted of six treatment groups and four replications, namely: the control group (P0); given high fat rations + duck egg yolk 2.5 ml/200gBW (P1); given high-fat rations + 8 mg/200gBW simvastatin (P2); and P1+ the dose of neem leaf ethanolic extract of 75; 100; and 125 mg/200gBW (P3; P4; and P5). Blood-glucose levels were analyzed by colorimetric enzymatic method using Roche Diagnostics Cobas C reagents kits. Blood-glucose level was determined using Roche / Hitachi cobas c systems automatically. Homogeneous and normally distributed data of blood-glucose levels, body weight and feed consumption were analyzed statistically using ANOVA followed by Duncan's test with a significance level of 5% using SPSS 16.0 software. The results indicated that giving the neem leaf ethanolic extract of could reduce the blood glucose levels. In this study, it was concluded that the neem leaf ethanolic extract of could potentially be used as an alternative to cure diabetes mellitus.

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Section: Resultssupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Blood-Glucose Levels of Rats Given High-Fat Diets after Administration of Neem Leaf Ethanolic Extract

2021

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“…Pemberian pakan tinggi lemak pada tikus dapat mempengaruhi ekspresi gen sel β pankreas yang dapat menyebabkan disfungsi dan apoptosis sel β pankreas (Dusaulcy et al, 2019). Hal ini sejalan dengan penelitian Sartika et al (2016) bahwa terdapat penurunan jumlah sel β normal pada pankreas tikus wistar yang diberi pakan yang mengandung asam lemak trans. Hal ini didukung dengan pendapat yang menyatakan bahwa lemak trans dipercaya sebagai salah satu sumber dari stres oksidatif Martin et al (2007) yaitu suatu kondisi dimana terjadi kelebihan reactive oxygen species (ROS) yang merupakan radikal bebas akibat tidak seimbangnya laju produksi dengan laju pembuangan ROS karena berlebihnya produksi ROS (McMichael, 2007).…”

Section: Hasil Dan Pembahasanunclassified

“…Asam lemak trans dapat meningkatkan kadar kolesterol LDL, tetapi secara bersamaan juga menurunkan kadar kolesterol HDL (Tuminah, 2009). Sartika et al (2016) melalui penelitiannya mengungkapkan bahwa terjadi penurunan jumlah sel β normal pada pankreas tikus wistar yang diberi pakan mengandung asam lemak trans. Penelitian tersebut didukung oleh Dusaulcy et al (2019) yang menyatakan bahwa pemberian pakan tinggi lemak pada tikus putih dapat mempengaruhi ekspresi gen sel β pankreas yang dapat menyebabkan disfungsi dan apoptosis sel β pankreas.…”

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Histopatologi Pankreas Tikus Putih (Rattus norvegicus L.) yang Diberi Pakan Tinggi Lemak dan Paparan Ekstrak Etanol Daun Mimba (Azadirachta indica A. Juss)

Ningrum

Isdadiyanto

Mardiati

2020

BAF

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Daun Mimba (Azadirachta indica A. Juss) mengandung antioksidan yang berpotensi untuk memperbaiki kerusakan pankreas. Penelitian ini bertujuan untuk menguji pengaruh ekstrak etanol daun mimba terhadap histopatologi pankreas tikus putih (Rattus norvegicus L.) yang diberi pakan tinggi lemak. Penelitian menggunakan Rancangan Acak Lengkap yang terdiri dari 6 perlakuan dan 4 kali pengulangan. Perlakuan meliputi kontrol (P0), pakan tinggi lemak (P1), simvastatin 8 mg (P2), dan uji dosis ekstrak etanol daun mimba 75; 100; dan 125 mg (P3; P4; dan P5). Parameter yang diukur adalah diameter dan luas pulau langerhans. Hasil penelitian menunjukkan bahwa ekstrak etanol daun mimba tidak berpengaruh nyata (p>0,05) terhadap diameter dan luas pulau langerhans serta tidak berpengaruh nyata (p>0,05) terhadap skoring kerusakan pulau langerhans tikus putih. Kesimpulan dari penelitian ini adalah esktrak etanol daun mimba dengan dosis 75; 100; dan 125 mg tidak dapat meningkatkan diameter dan luas pulau langerhans tikus putih yang diberi pakan tinggi lemak. Kata kunci : ekstrak etanol daun Mimba, pakan tinggi lemak, pulau langerhans, tikus putih

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Effect of Trans Fatty Acid on Glucose Level and Pancreatic β Cell in Rats

Cited by 2 publications

References 16 publications

Blood-Glucose Levels of Rats Given High-Fat Diets after Administration of Neem Leaf Ethanolic Extract

Blood-Glucose Levels of Rats Given High-Fat Diets after Administration of Neem Leaf Ethanolic Extract

Histopatologi Pankreas Tikus Putih (Rattus norvegicus L.) yang Diberi Pakan Tinggi Lemak dan Paparan Ekstrak Etanol Daun Mimba (Azadirachta indica A. Juss)

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