Effect of transcutaneous application of gaseous carbon dioxide on cutaneous microcirculation

Finžgar, Miha; Melik, Ž.; Cankar, Ksenija

doi:10.3233/ch-141898

Cited by 25 publications

(26 citation statements)

References 24 publications

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“…Furthermore, exercise training has been shown to induce collateral circulation for increasing the blood supply and maintaining the function of the ischemic muscle (Hoier et al 2010;Kehler et al 2013;Milkiewicz et al 2005;Schirmer et al 2015). In addition, both clinical and experimental investigations have indicated the beneficial effects of CO 2 therapy for promoting the blood flow to the ischemic limb in peripheral artery D r a f t disease (Dogliotti et al 2011;Finzgar et al 2015;Hartmann et al 1997aHartmann et al , 1997bIrie et al 2005;Izumi et al 2015;Nishimura et al 2002;Pagourelias et al 2011). However, extensive research work is needed to understand the mechanisms of CO 2 -induced increase in blood flow in the ischemic skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis

Elimban

Dhalla

2017

Can. J. Physiol. Pharmacol.

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In this study, we investigated the effects of CO water-bath therapy on blood flow and angiogenesis in the ischemic hind limb, as well as some plasma angiogenic factors in peripheral ischemic model. The hind limb ischemia was induced by occluding the femoral artery for 2 weeks in rats and treated with or without CO water-bath therapy at 37 °C for 4 weeks (20 min treatment every day for 5 days per week). The peak blood flow and minimal and mean blood flow in the ischemic skeletal muscle were markedly increased by the CO water-bath therapy. This increase in blood flow was associated with development of angiogenesis in the muscle, as well as reduction in the ischemia-induced increase in plasma malondialdehyde levels. Although plasma vascular endothelial growth factor and nitric oxide levels were increased in animals with peripheral ischemia, the changes in these biomarkers were not affected by CO water-bath therapy. These results suggest that augmentation of blood flow in the ischemic hind limb by CO water-bath therapy may be due to the development of angiogenesis and reduction in oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis

Elimban

Dhalla

2017

Can. J. Physiol. Pharmacol.

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“…Although CO 2 is a powerful vasodilator (Finzgar et al 2015;Ito et al 1989), it is highly unlikely that the observed increase in blood flow by CO 2 water-bath therapy in diabetic ischemic group under the experimental conditions of this study is due to any direct effect of CO 2 on blood vessels. Furthermore, alternation in blood viscosity cannot be considered to explain the improvement in blood flow (Dhalla et al 2017) in the diabetic ischemic group because the plasma levels of cholesterol triglyceride, HDL, and glucose were not affected by the CO 2 water-D r a f t bath therapy.…”

Section: Discussionmentioning

confidence: 74%

Effects of CO₂ water-bath treatment on blood flow and angiogenesis in ischemic hind limb of diabetic rat

Elimban

Bhullar

et al. 2018

Can. J. Physiol. Pharmacol.

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The effects of CO water-bath therapy on the hind limb of diabetic animals with or without peripheral ischemia were examined. Diabetes was induced in rats by administering streptozotocin (65 mg·kg), and the animals were then divided into 3 groups. After 4 weeks, peripheral ischemia was induced by ligation of the femoral artery for 2 weeks in 2 groups (diabetic ischemic) of diabetic rats, whereas the femoral artery was not occluded in the third group (diabetic). All these animals were subjected to water-bath therapy (with or without CO mixing; 20 min·day for 5 days·week) for a period of 4 weeks. Both peak and mean flows, unlike minimal flow, in diabetic ischemic limbs were increased about a twofold by CO water-bath treatment. Morphological examination of hind limb tissue sections revealed about a twofold increase in the small artery count in diabetic ischemic animals upon CO water-bath treatment. These results indicate that CO water-bath therapy augments the blood flow and development of angiogenesis in the skeletal muscle of diabetic ischemic animals and thus may be of some benefit for the treatment of peripheral arterial disease in diabetes.

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“…Najubjedljiviji dokazi postoje za primjenu kineziterapije koja povećava gustinu intraepidermalnih nervnih vlakana, kapacitet regeneracije i funkciju perifernih nerava, smanjuje bol i umor i poboljšava funkcionalni ishod neuropatije (uključujući ravnotežu, rizik od pada i parametre hoda) [22][23][24][25]. Od ostalih modaliteta fizikalne terapije, najčešće se primjenjuju transkutana električna nervna stimulacija (TENS), magnetoterapija i galvanske kupke [26][27][28][29], dok su vakumkompresivna terapija i karbo tretman manje primjenjivani i istraživani u liječenju dijabetesne polineuropatije [30][31][32]. U studiji koja je poredila efikasnost primjene kombinovanih fizikalnih procedura (stabilna galvanizacija, impulsno elektromagnetno polje, transkutana električna nervna stimulacija-TENS i kineziterapija) u odnosu na liječenje alfaliponskom kiselinom, nađeno je da obe metode liječenja poboljšavaju elektromioneurografske parametre (brzinu provodljivosti kroz n. peroneus i n. suralis) kod bolesnika sa dijabetesnom neuropatijom.…”

Section: Discussionunclassified

Efficiency of alpha-lipoic acid and physical therapy in patients with diabetes polyuropathy

Bojinović-Rodić¹,

Ljubojević²,

Pešta³

et al. 2017

Tim Med Glas

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ZAVOD ZA FIZIKALNU MEDICINU I REHABILITACIJU "DR MIROSLAV ZOTOVIĆ" BANJA LUKA, REPUBLIKA SRPSKA, BOSNA I HERCEGOVINA, SLATINSKA 11 SAŽETAK: Uvod: Dijabetesna polineuropatija je najčešća mikrovaskularna komplikacija dijabetesa. Alfalipoinska kiselina (ALK) i fizikalna terapija se koriste u liječenju ovog progresivnog oboljenja. Cilj rada je bio ispitati efikasnost kombinovane primjene ALK i fizikalne terapije kod pacijenata sa dijabetesnom polineuropatijom i utvrditi da li dužina trajanja dijabetesa, dužina trajanja simptoma polineuropatije, nivo glikoregulacije, indeks tjelesne mase i izraženost simptoma polineuropatije prije terapije utiču na bolji terapijski odgovor. Istraživanje je obuhvatilo 95 pacijenta sa dijabetesnom polineuropatijom kojima je parenteralno aplikovana alfa-lipoinska kiselina u kombinaciji sa kineziterapijom, vakumkompresivnom terapijom, karbotretmanom i galvanskim kupkama. Za procjenu efikasnosti terapije korišteni su Ukupni skor simptoma neuropatije (Neuropathy Total Symptom Score-4-TSS-4) i Toronto klinički sistem bodovanja (Toronto Clinical Scoring Sistem-Toronto CSS). Nakon primjenjenih terapijskih procedura, vrijednosti i TSS-4 i Toronto CSS su se statistički značajno smanjile (p< 0,01). Dužina trajanja dijabetesa, dužina trajanja simptoma polineuropatije, nivo glikoregulacije i indeks tjelesne mase nisu statistički značajno korelirali sa stepenom smanjenja TSS-4 (p> 0,05), dok je nađena statistički značajna negativna korelacija između vrijednosti TSS-4 prije terapije i stepena njegovog smanjenja (p< 0,05). Kombinovana primjena alfa-lipoinske kiseline i fizikalne terapije je efikasna u smanjenju subjektivnih simptoma i znakova dijabetesne polineuropatije. Terapijski odgovor je bolji ukoliko su simptomi polineuropatije manje izraženi. Ključne riječi: dijabetesna polineuropatija, alfa-lipoinska kiselina, fizikalne procedure. Summary:Diabetic polyneuropathy is the most common microvascular complication of diabetes. Alpha-lipoic acid and physical therapy are used in the treatment of this progressive disease. Aim of this study was to assess the efficacy of combined use of alpha-lipoic acid and physical therapy in patients with diabetic polyneuropathy and identify the factors which lead to a better therapeutic response. The study included 95 patients with diabetic polyneuropathy who were parenterally treated with alpha-lipoic acid in combination with the kinesiotherapy, vacuum compression therapy, carbon dioxide therapy and galvanic baths. The Neuropathy Total Symptom Score-4-TSS-4 and the Toronto Clinical Scoring System (Toronto CSS) were used to evaluate the effectiveness of the therapy. After the applied therapeutic procedures, the values of both TSS-4 and Toronto CSS statistically significantly decreased (p <0.01). The duration of diabetes, duration of symptoms of polyneuropathy, the level of glycemic control and body mass index were not significantly correlated with the degree of reduction in TSS-4 (p> 0.05), while we found a statistically significant negative correlation between the v...

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Effect of transcutaneous application of gaseous carbon dioxide on cutaneous microcirculation

Abstract: Our results confirm a local vasodilatory effect of applied CO2 therapy. This finding indicates its potential clinical use.

Cited by 25 publications

References 24 publications

Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis

Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis

Effects of CO₂ water-bath treatment on blood flow and angiogenesis in ischemic hind limb of diabetic rat

Efficiency of alpha-lipoic acid and physical therapy in patients with diabetes polyuropathy

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Effect of transcutaneous application of gaseous carbon dioxide on cutaneous microcirculation

Abstract: Our results confirm a local vasodilatory effect of applied CO2 therapy. This finding indicates its potential clinical use.

Cited by 25 publications

References 24 publications

Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis

Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis

Effects of CO2 water-bath treatment on blood flow and angiogenesis in ischemic hind limb of diabetic rat

Efficiency of alpha-lipoic acid and physical therapy in patients with diabetes polyuropathy

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Effects of CO₂ water-bath treatment on blood flow and angiogenesis in ischemic hind limb of diabetic rat