Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

Abstract

Purpose: The effect of travoprost 0.004% on 24-hour intraocular pressure (IOP) was examined in patients with normal tension glaucoma (NTG). Subjects and methods: This study included 17 patients with newly diagnosed unilateral NTG. IOP was measured at three-hour intervals over 24 hours by Goldman applanation tonometer in patients taking topical travoprost 0.004% and was compared retrospectively with 24-hour IOP data in untreated eyes. Results: IOP values were significantly reduced at individual time points after treatment (P , 0.01). Mean 24-hour IOP, maximum 24-hour IOP, minimum 24-hour IOP, and 24-hour IOP fluctuations at baseline (mean ± SD) were 12.9 ± 2.2 mmHg, 15.4 ± 2.7 mmHg, 10.5 ± 2.2 mmHg, and 4.9 ± 1.2 mmHg, respectively, and were significantly reduced to 10.3 ± 2.0 mmHg, 12.4 ± 2.5 mmHg, 8.5 ± 1.9 mmHg (all P , 0.001), and 3.9 ± 1.5 mmHg (P , 0.05), respectively, after treatment. The rate of IOP reduction greater than 20% was 58.8% (10 eyes) for maximum 24-hour IOP and 53.0% (nine eyes) for mean 24-hour IOP. Conclusion: Travoprost reduced IOP throughout the 24-hour study period, with over half of the eyes examined showing IOP reduction exceeding 20%.

The diurnal and nocturnal effects of travoprost in normal-tension glaucoma

“…Nomura et al performed the only study reporting on the 24-hour effects of travoprost in NTG. 13 In their study, mean 24-hour IOP was reduced from 12.9 mmHg to 10.3 mmHg (20% reduction). Of note in their protocol, subjects were awoken and walked to a slit lamp to perform IOP readings in an upright position overnight.…”

Role of 24-Hour Intraocular Pressure Monitoring in Glaucoma Management

“…In view of the suggestion of setting a more comprehensive management target regarding patients' 24-hour IOP profiles, we have also discussed the effectiveness of glaucomatous medications, laser trabeculoplasty, and trabeculectomy in optimizing various 24-hour IOP parameters. According to current data, prostaglandin analogues (especially bimatoprost and travoprost [51, 85]) were the most effective topical eyedrops to achieve a uniform 24-hour IOP reduction [83–86], and they were also effective in reducing the maximum and minimum IOP and short-term IOP fluctuations [87]. In particular, evening administration of prostaglandin analogues was shown to be better than morning dosing to lower daytime IOP in patients with POAG [19, 81, 83, 92].…”

“…Stewart et al conducted a meta-analysis of studies that assessed the 24-hour efficacy of antiglaucoma medications and concluded that bimatoprost followed by travoprost were the two most effective IOP-reducing medications [51, 85]. In patients with newly diagnosed NTG, topical travoprost (0.004%) was shown to significantly reduce mean IOP, maximum and minimum IOP, and short-term IOP fluctuations [87]. Seibold and Kahook found that travoprost significantly lowered IOP at all time points during diurnal and nocturnal periods in an interventional trial involving 27 NTG patients [88].…”

Travoprost with sofZia® preservative system lowered intraocular pressure of Japanese normal tension glaucoma with minimal side effects

“…Travoprost with sofZia® use has been reported in limited numbers of NTG patients, with a potent IOP lowering effect and minimal corneal damage. 12 , 13 We, therefore, expanded on these findings and conducted a study with a large number of Japanese NTG patients.…”