Effect of triiodothyronine on hyperandrogenism in women

Kazanavičius, Gintautas; Purtokaitė-Labutinienė, Irina; Kozlovienė, Dalia; Kruminis, Valdemaras; Kreivaitienė, Eglė

doi:10.1186/1756-6614-6-s2-a27

Cited by 2 publications

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“…Thus, the present study identifies that T3/ testosterone ratio can predict BC with higher odds when compared with other studied thyroid hormone/sex hormone ratios in identifying BC risk. The imbalance of thyroid hormones causes the dysfunction of the reproductive system (22) which might also impact on the concentrations of sex hormones. Interestingly testosterone sometimes functions via conversion to estradiol [23] and lower testosterone in females might impact on obesity and poor glucose control.…”

Section: Discussionmentioning

confidence: 99%

Are Thyroid and Sex Hormone Ratios Predictive of Breast Cancer Risk? A Preliminary Study among A Cohort of Sri Lankan Breast Cancer Patients

Akalanka

Ekanayake

Samarasinghe

2023

Journal of Basic and Clinical Health Sciences

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Purpose: The association of thyroid related diseases and sex hormones with breast cancer (BC) is reported with inconclusive results. Objectives: The study was designed to analyze the thyroid/sex hormone ratios of BC patients. Methodology: TSH, T3, T4, estrogen, progesterone and testosterone concentrations of newly diagnosed breast cancer patients (n=155) aged 30 to 75 years and age-matched normal controls (n=75) were analyzed. Thyroid: sex hormone ratios were calculated. Data on history of thyroid related diseases were collected. Results and Discussion: History of thyroid related diseases was significantly higher (p

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Section: Discussionmentioning

confidence: 99%

Are Thyroid and Sex Hormone Ratios Predictive of Breast Cancer Risk? A Preliminary Study among A Cohort of Sri Lankan Breast Cancer Patients

Akalanka

Ekanayake

Samarasinghe

2023

Journal of Basic and Clinical Health Sciences

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“…Thus the present study identi es that T 3 / testosterone ratio can predict BC with higher odds when compared with other studied thyroid hormones/ sex hormone ratios in identifying BC risk. The imbalance of thyroid hormones causes the dysfunction of the reproductive system [22] which might also impact on the concentrations of sex hormones.…”

Section: Discussionmentioning

confidence: 99%

Thyroid and Sex Hormones Ratios in Predicting Breast Cancer Risk

Akalanka

Ekanayake

Samarasinghe

2021

Preprint

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Purpose: The study intended to analyze the incidence of thyroid related diseases and to assess thyroid to sex hormones ratios of breast cancer (BC) patients Methods: TSH, T3, T4, Estrogen, progesterone and testosterone levels of newly diagnosed BC patients (n=155) aged 30 to 75 years and age-matched normal controls (n=75) were analyzed. Data on history of thyroid related diseases were collected from an interviewer administered questionnaire. Thyroid/sex hormone ratios were analyzed and compared against healthy women. Results: History of thyroid related diseases was significantly higher (p<0.05) in BC patients compared to controls. Patients (10%) with history of thyroid related diseases were excluded from the study. Subclinical hyperthyroidism was identified among 14% of the remaining BC patients and was the only dysfunction (7%) among healthy women. Significantly higher (p<0.05) mean T3 and T4 values, lower TSH levels and non-significant levels of estrogen and progesterone were observed in patients with BC when compared to healthy. Serum Testosterone of BC patients were significantly low (p<0.05). Considering the thyroid to sex hormones ratios among postmenopausal women, T3/testosterone, T4/testosterone, T3/estrogen, T4/ estrogen, ratios were significantly different in the two groups and the highest significance was found with T3/testosterone. Cutoff values studied from receiver operative characteristic curves indicated that a woman having T3/testosterone above 7.47 showed 12.5 times odds (p=0.000) of being diagnosed with BC. Conclusion: Incidence of thyroid related diseases are higher among BC patients and elevation of T3/testosterone ratio indicated a significant risk of BC. However, a study involving a larger number of participants could confirm the above.

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Effect of triiodothyronine on hyperandrogenism in women

Cited by 2 publications

References 0 publications

Are Thyroid and Sex Hormone Ratios Predictive of Breast Cancer Risk? A Preliminary Study among A Cohort of Sri Lankan Breast Cancer Patients

Are Thyroid and Sex Hormone Ratios Predictive of Breast Cancer Risk? A Preliminary Study among A Cohort of Sri Lankan Breast Cancer Patients

Thyroid and Sex Hormones Ratios in Predicting Breast Cancer Risk

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