Effect of tumour associated tissue eosinophilia on survival of women with stage IB carcinoma of the uterine cervix.

Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and Regulated on Activation Normal T Cell Expressed and Secreted Are Expressed by Human Breast Carcinoma Cells and Support Eosinophil Adhesion and Activation

“…4 In vitro, eosinophils can enhance the tumoricidal activity of macrophages 34 and in vivo, blood eosinophilia or eosinophil infiltration into some tumors is associated with improved prognosis. 3,7,8,35 Despite the overwhelming data showing that eosinophils are associated with numerous types of cancer, little is known about the molecular mechanisms required for localization of eosinophils to these sites.…”

“…There are several studies that suggest that eosinophil tumor infiltration is associated with improved prognosis. 3,7,35 There are an equal number of studies showing either no role for eosinophils or an association with a poor prognosis. [42][43][44] Recently it has been suggested that eosinophils may not play a direct role in tumor cell clearance, but may instead participate in tissue remodeling.…”

“…3,4 Deposition of eosinophilic granular proteins has been found in breast, 5 ovarian, and uterine tumors 6 and in some studies the presence of eosinophils is one indicator of increased survival. 7,8 Thus, there is increasing evidence showing that eosinophils infiltrate into tumor sites, suggesting that these cells may play a role in host-tumor interactions. Despite this, little is known about the mechanisms of eosinophil infiltration into tumor sites.…”

Influence of pathological tumour variables on long-term survival in resectable gastric cancer

“…The improved prognosis associated with the presence of marked tumour-associated tissue eosinophilia (TATE) in two cancers at either end of the gut is interesting and merits further investigation even if this is only found in a small percentage (8% in the present study) of these gastrointestinal cancers. Abnormal recruitment of tissue eosinophils is encountered in a variety of medical conditions including specific malignancies e.g., Hodgkin's disease certain types of leukaemia (Ogata et al, 1998) and some solid tumours (Pretlow et al, 1983;Iwasaki et al, 1986;Bethwaite et al, 1993;Caruso et al, 1993;Yu et al, 1995;Leighton et al, 1996;Songun et al, 1996;Ono et al, 1997;Geisinger et al, 1998;Tajima et al, 1998;Hong et al, 1999;Nielsen et al, 1999;Moezzi et al, 2000). TATE may simply be a surrogate marker of a distinctive cytokine response to an infiltrative tumour.…”

Sipuleucel-T (Provenge) autologous vaccine approved for treatment of men with asymptomatic or minimally symptomatic castrate-resistant metastatic prostate cancer

“…While IgG and IgM could induce antibody-dependent cellular cytotoxicity, opsonization for tumoricidal macrophages or complement-mediated lysis, there has been no data offered to support this. Eosinophilia has been observed in many human cancers 9,10 and as a positive prognostic indicator in some, [11][12][13][14][15][16] and rodent models show eosinophilic anti-tumor activity. 17 However, their role in the clinical tumor microenvironment is quite unclear.…”