CFD simulations of the multiphase flow in technical equipment are feasible within the framework of interpenetrating continua, the so-called two-fluid modelling. Predictions with multiphase CFD are only possible if a fixed set of closures for the interfacial exchange terms is available that has been validated for a wide range of flow conditions and can therefore reliably be used also for unknown flow problems. To this end, a baseline model, which is applicable for adiabatic bubbly flow, has been specified recently and has been implemented in OpenFOAM. In this work, we compare simulation results obtained using the baseline model with three different sets of experimental data for dispersed gas-liquid pipe flow. Air and water under similar flow conditions have been used in the different experiments, so that the main difference between the experiments is the variation of the pipe diameter from 25 mm to 200 mm. Gas fraction and liquid velocity are reasonably well reproduced, in particular in the bulk of the flow. Discrepancies can be seen in the turbulent kinetic energy, the gas velocity and in the wall peaks of the gas fraction. These can partly be explained by the simplified modelling, but to some extent must be attributed to uncertainty in the experimental data. The need for improved near-wall modelling, turbulence modelling and modelling of the bubble size distribution is highlighted.