Effect of turmeric on adiponectin, sexual function and sexual hormones in stressed mice

Sahebzad, Elahe Sadeghi; Tehranian, Najmeh; Kazemnejad, Anoshirvan; Sharifi, M; Mojab, Faraz; Azin, Ali

doi:10.1016/j.lfs.2021.119575

Cited by 3 publications

(5 citation statements)

References 33 publications

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“…A recent study has corroborated the nonsignificant P 4 difference between the examined groups by reporting that maternal CUR supplementation improved placental weight and foetal growth without affecting P 4 levels (Qi et al, 2020). Our results are opposed to those found by Sahebzad et al (2021), who reported an increase in E 2 and P 4 concentrations in stressed‐nonpregnant rats. This discrepancy might be due to the difference in species (goats vs. rats) and physiological state (pregnancy vs. cyclic).…”

Section: Discussioncontrasting

confidence: 99%

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

El‐Sherbiny,

Samir,

Youssef

et al. 2024

Animal Physiology Nutrition

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This experiment was designed to investigate the impact of curcumin‐olive oil nanocomposite (CONC) supplementation on uteroplacental hemodynamics and ultrasonographic measurements as well as maternal oxidative status in midgestating goats. Twelve synchronized pregnant goats (85.58 ± 1.08 days of gestation; mean ± SD) were uniformly assigned to two groups (n = 6/group); the first group received daily oral supplementation of CONC (3 mg/kg body weight; nanocurcumin [NC] group) for 32 days, and the second group was offered physiological saline (control) following the NC group timeline. The goats of both groups were examined at 3‐day intervals for middle uterine (MUA) and umbilical (UMA) arteries hemodynamics (pulsatility index [PI], resistive index [RI], systole/diastole [S/D] and blood flow rate [BFR]) and diameters, uteroplacental thickness (UPT), placentomes' diameter (PD) and echogenicity, steroid hormones (progesterone and estradiol 17β), oxidative biomarkers (total antioxidant capacity [TAC], catalase [CAT], malondialdehyde [MDA]), nitric oxide (NO) and blood cells DNA integrity. The UPT (p = 0.012) and PD (p = 0.021) values were higher in the NC group than in their counterparts' control group (D11–32). There were increases in diameter (p = 0.021 and p = 0.012) and decreases (p = 0.021, p = 0.016 and p = 0.041 [MUA]; p = 0.015, p = 0.023 and p = 0.011 [UMA] respectively) in Doppler indices (PI, RI and S/D) of the MUA and UMA in the NC group compared to the control group (D14–32). On D20–32 (MUA) and D14–32 (UMA), the NC goats had higher BFR than the control group (p = 0.021, 0.018 respectively). The means of blood cells with fragmented DNA were lower (p = 0.022) in the NC group than in the control group on Days 8 and 21 postsupplementation. There were increases in CAT and NO (D20–32; p = 0.022 and p = 0.004 respectively), and TAC (D17–32; p = 0.007) levels in the NC goats compared to the control ones. The NC group had lower (p = 0.029) concentrations of MDA than the control group on Day 20 postsupplementation onward. In conclusion, oral supplementation of CONC improved uteroplacental blood flow and the antioxidant capacity of midgestating goats.

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Section: Discussioncontrasting

confidence: 99%

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

El‐Sherbiny,

Samir,

Youssef

et al. 2024

Animal Physiology Nutrition

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“…After CLE treatment, signs of exhaustion, mating ability with impotence, contraction of reproductive organs, testosterone levels and pathological testicular status significantly improved. These findings suggest that CLE might be a potential treatment for Kidney‐Yang deficiency syndrome, consistent with previous reports indicating that turmeric can increase sexual function and sex hormone levels 11,12 …”

Section: Discussionsupporting

confidence: 92%

“…These findings suggest that CLE might be a potential treatment for Kidney-Yang deficiency syndrome, consistent with previous reports indicating that turmeric can increase sexual function and sex hormone levels. 11,12 Testosterone is synthesized from cholesterol in a multi-step enzymatic process in response to pituitary hormones. StAR appears to be the rate-determining step, transferring cholesterol from cellular stores to the inner mitochondrial membrane, where it is metabolized by CYP11A to pregnenolone.…”

Section: Discussionmentioning

confidence: 99%

“…They arrested spermatogenesis and affected the androgen synthesis by inhibiting the Leydig cell function or the hypothalamus‐pituitary axis (HPA) 10 . Simultaneously, several studies emphasize the involvement of turmeric and curcumin in improving sexual function and sex hormones profiling 11,12 . Furthermore, it has been shown to alleviate adverse reproductive outcomes of various physiological or environmental factors and exerts advantageous effects on the sexual glands, testis, and ovary via potent antioxidant, anti‐inflammatory and membrane‐stabilizing properties 13–15 .…”

Section: Introductionmentioning

confidence: 99%

“…10 Simultaneously, several studies emphasize the involvement of turmeric and curcumin in improving sexual function and sex hormones profiling. 11,12 Furthermore, it has been shown to alleviate adverse reproductive outcomes of various physiological or environmental factors and exerts advantageous effects on the sexual glands, testis, and ovary via potent antioxidant, anti-inflammatory and membranestabilizing properties. [13][14][15] Thus, different effects of turmeric might depend on the doses, and various models studied.…”

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confidence: 99%

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Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells

Zhang,

Yang,

Xue

et al. 2024

J Cellular Molecular Medi

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Curcuma longa, best known for its culinary application as the main constituent of curry powder, has shown potential impact on the reproductive system. This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney‐Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone‐induced mice. CLE effectively reversed hydrocortisone‐induced Kidney‐Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage. Our in vitro study further indicated that CLE stimulated testosterone production via upregulating the mRNA and protein expression of steroidogenic enzymes in Leydig cells. It significantly improved H89‐inhibited protein expression of StAR and cAMP‐response element‐binding (CREB), as well as melatonin‐suppressed StAR protein expression. The data obtained from this study suggest that CLE could alleviate Kidney‐Yang deficiency symptoms and stimulate testosterone production by upregulating the steroidogenic pathway. This research identifies CLE as a potential nutraceutical option for addressing testosterone deficiency diseases.

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The Golden Spice for Life: Turmeric with the Pharmacological Benefits of Curcuminoids Components, Including Curcumin, Bisdemethoxycurcumin, and Demethoxycurcumins

Shahrajabian

Sun

2024

COS

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Background: Turmeric (Curcuma longa L.), belonging to the Zingiberaceae family, is a perennial rhizomatous plant of tropical and subtropical regions. The three major chemical components responsible for the biological activities of turmeric are curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Method: The literature search included review articles, analytical studies, randomized control experiments, and observations, which have been gathered from various sources, such as Scopus, Google Scholar, PubMed, and ScienceDirect. A review of the literature was carried out using the keywords: turmeric, traditional Chinese medicine, traditional Iranian medicine, traditional Indian medicine, curcumin, curcuminoids, pharmaceutical benefits, turmerone, demethoxycurcumin, and bisdemethoxycurcumin. The main components of the rhizome of the leaf are α-turmerone, β-turmerone, and ar-turmerone Result: The notable health benefits of turmeric are antioxidant activity, gastrointestinal effects, anti-cancer effects, cardiovascular and antidiabetic effects, antimicrobial activity, photoprotector activity, hepatoprotective and renoprotective effects, and appropriate for the treatment of Alzheimer's disease and inflammatory and edematic disorders. Discussion: Curcuminoids are phenolic compounds usually used as pigment spices with many health benefits, such as antiviral, antitumour, anti-HIV, anti-inflammatory, antiparasitic, anticancer, and antifungal effects. Curcumin, bisdemethoxycurcumin, and demethoxycurcumin are the major active and stable bioactive constituents of curcuminoids. Curcumin, which is a hydroponic polyphenol, and the main coloring agent in the rhizomes of turmeric, has anti-inflammatory, antioxidant, anti-cancer, and anticarcinogenic activities, as well as beneficial effects for infectious diseases and Alzheimer's disease. Bisdemethoxycurcumin possesses antioxidant, anti-cancer, and anti-metastasis activities. Demethoxycurcumin, which is another major component, has anti-inflammatory, antiproliferative, and anti-cancer activities and is the appropriate candidate for the treatment of Alzheimer's disease. Conclusion: The goal of this review is to highlight the health benefits of turmeric in both traditional and modern pharmaceutical sciences by considering the important roles of curcuminoids and other major chemical constituents of turmeric.

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Effect of turmeric on adiponectin, sexual function and sexual hormones in stressed mice

Cited by 3 publications

References 33 publications

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells

The Golden Spice for Life: Turmeric with the Pharmacological Benefits of Curcuminoids Components, Including Curcumin, Bisdemethoxycurcumin, and Demethoxycurcumins

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